Ironjustic
Tue, Mar-13-07, 17:16
Conversion of alpha-linolenic acid in humans is influenced by
the absolute amounts of alpha-linolenic acid and linoleic acid
in the diet and not by their ratio; 2006
Goyens, P.L.L.
Titel Conversion of alpha-linolenic acid in humans is
influenced by the absolute amounts of alpha-linolenic acid
and linoleic acid in the diet and not by their ratio
Auteur(s) Goyens, P.L.L. Spilker, M.E. Zock, P.L. Katan, M.B.
Mensink, R.P.
Datum 2006 Trefwoord(en) Afdeling Humane voeding
Samenvatting BACKGROUND: Human in vivo data on dietary
determinants of alpha-linolenic acid (ALA; 18:3n-3)
metabolism are scarce. OBJECTIVE: We examined whether
intakes of ALA or linoleic acid (LA;
18:2n-6) or their ratio influences ALA metabolism. DESIGN:
During 4 wk, 29 subjects received a control diet (7% of
energy from LA, 0.4% of energy from ALA, ALA-to-LA ratio =
1:19). For the next 6 wk, a control diet, a low-LA diet (3%
of energy from LA, 0.4% of energy from ALA, ratio = 1:7),
or a high-ALA diet (7% of energy from LA, 1.1% of energy
from ALA, ratio = 1:7) was consumed. Ten days before the
end of each dietary period, [U-13C]ALA was administered
orally for 9 d. ALA oxidation was determined from breath.
Conversion was estimated by using compartmental modeling of
[13C]- and [12C]n-3 fatty acid concentrations in fasting
plasma phospholipids. RESULTS: Compared with the control
group, ALA incorporation into phospholipids increased by
19.6% in the low-LA group (P = 0.012) and decreased by 8.0% in
the high- ALA group (P < 0.001). In absolute amounts, it
increased by 34.3 mg (P
= .020) in the low-LA group but hardly changed in the
= high-ALA group.
Nearly all ALA from the plasma phospholipid pool was converted
into eicosapentaenoic acid. Conversion of eicosapentaenoic
acid into docosapentaenoic acid and docosahexaenoic acid
hardly changed in the 3 groups and was <0.1% of dietary ALA.
In absolute amounts, it was unchanged in the low-LA group, but
increased from 0.7 to 1.9 mg (P = .001) in the high-ALA group.
ALA oxidation was unchanged by the dietary interventions.
CONCLUSION: The amounts of ALA and LA in the diet, but not
their ratio, determine ALA conversion
Link http://library.wur.nl/wasp/bestanden/LUWPUBRD_00348072_A-
502_001.pdf Objecttype Article/Letter to editor Objectformaat
application/pdf
Bron American Journal of Clinical Nutrition 84 (2006) 1
ISSN: 0002-9165
Rechten Wageningen UR
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
the absolute amounts of alpha-linolenic acid and linoleic acid
in the diet and not by their ratio; 2006
Goyens, P.L.L.
Titel Conversion of alpha-linolenic acid in humans is
influenced by the absolute amounts of alpha-linolenic acid
and linoleic acid in the diet and not by their ratio
Auteur(s) Goyens, P.L.L. Spilker, M.E. Zock, P.L. Katan, M.B.
Mensink, R.P.
Datum 2006 Trefwoord(en) Afdeling Humane voeding
Samenvatting BACKGROUND: Human in vivo data on dietary
determinants of alpha-linolenic acid (ALA; 18:3n-3)
metabolism are scarce. OBJECTIVE: We examined whether
intakes of ALA or linoleic acid (LA;
18:2n-6) or their ratio influences ALA metabolism. DESIGN:
During 4 wk, 29 subjects received a control diet (7% of
energy from LA, 0.4% of energy from ALA, ALA-to-LA ratio =
1:19). For the next 6 wk, a control diet, a low-LA diet (3%
of energy from LA, 0.4% of energy from ALA, ratio = 1:7),
or a high-ALA diet (7% of energy from LA, 1.1% of energy
from ALA, ratio = 1:7) was consumed. Ten days before the
end of each dietary period, [U-13C]ALA was administered
orally for 9 d. ALA oxidation was determined from breath.
Conversion was estimated by using compartmental modeling of
[13C]- and [12C]n-3 fatty acid concentrations in fasting
plasma phospholipids. RESULTS: Compared with the control
group, ALA incorporation into phospholipids increased by
19.6% in the low-LA group (P = 0.012) and decreased by 8.0% in
the high- ALA group (P < 0.001). In absolute amounts, it
increased by 34.3 mg (P
= .020) in the low-LA group but hardly changed in the
= high-ALA group.
Nearly all ALA from the plasma phospholipid pool was converted
into eicosapentaenoic acid. Conversion of eicosapentaenoic
acid into docosapentaenoic acid and docosahexaenoic acid
hardly changed in the 3 groups and was <0.1% of dietary ALA.
In absolute amounts, it was unchanged in the low-LA group, but
increased from 0.7 to 1.9 mg (P = .001) in the high-ALA group.
ALA oxidation was unchanged by the dietary interventions.
CONCLUSION: The amounts of ALA and LA in the diet, but not
their ratio, determine ALA conversion
Link http://library.wur.nl/wasp/bestanden/LUWPUBRD_00348072_A-
502_001.pdf Objecttype Article/Letter to editor Objectformaat
application/pdf
Bron American Journal of Clinical Nutrition 84 (2006) 1
ISSN: 0002-9165
Rechten Wageningen UR
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk