Ironjustic
Sat, Mar-10-07, 16:17
Neurobiol Aging. 2007 Mar 6; [Epub ahead of print]Reversion of
age- related recognition memory impairment by iron chelation
in rats.de Lima MN, Dias CP, Torres JP, Dornelles A, Garcia
VA, Scalco FS, Guimaraes MR, Petry RC, Bromberg E, Constantino
L, Budni P, Dal-Pizzol F, Schroder N. Neurobiology and
Developmental Biology Laboratory, Faculty of Biosciences,
Pontifical Catholic University, 90619-900 Porto Alegre, RS,
Brazil; Graduate Program in Biomedical Gerontology, Institute
for Geriatrics and Gerontology, Sao Lucas Hospital, Pontifical
Catholic University, 90619-900 Porto Alegre, RS, Brazil.
It is now generally accepted that iron accumulates in the
brain during the ageing process. Increasing evidence
demonstrate that iron accumulation in selective regions of the
brain may generate free radicals, thereby possessing
implications for the etiology of neurodegenerative disorders.
In a previous study we have reported that aged rats present
recognition memory deficits. The aim of the present study was
to evaluate the effect of desferoxamine (DFO), an iron
chelator agent, on age-induced memory impairment. Aged Wistar
rats received intraperitoneal injections of saline or DFO
(300mg/kg) for 2 weeks. The animals were submitted to a novel
object recognition task 24h after the last injection.
DFO-treated rats showed normal recognition memory while the
saline group showed long-term recognition memory deficits. The
results show that DFO is able to reverse age- induced
recognition memory deficits. We also demonstrated that DFO
reduced the oxidative damage to proteins in cortex and
hippocampus. Thus, the present findings provide the first
evidence that iron chelators might prevent age-related memory
dysfunction.
PMID: 17346856 [PubMed - as supplied by publisher]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
age- related recognition memory impairment by iron chelation
in rats.de Lima MN, Dias CP, Torres JP, Dornelles A, Garcia
VA, Scalco FS, Guimaraes MR, Petry RC, Bromberg E, Constantino
L, Budni P, Dal-Pizzol F, Schroder N. Neurobiology and
Developmental Biology Laboratory, Faculty of Biosciences,
Pontifical Catholic University, 90619-900 Porto Alegre, RS,
Brazil; Graduate Program in Biomedical Gerontology, Institute
for Geriatrics and Gerontology, Sao Lucas Hospital, Pontifical
Catholic University, 90619-900 Porto Alegre, RS, Brazil.
It is now generally accepted that iron accumulates in the
brain during the ageing process. Increasing evidence
demonstrate that iron accumulation in selective regions of the
brain may generate free radicals, thereby possessing
implications for the etiology of neurodegenerative disorders.
In a previous study we have reported that aged rats present
recognition memory deficits. The aim of the present study was
to evaluate the effect of desferoxamine (DFO), an iron
chelator agent, on age-induced memory impairment. Aged Wistar
rats received intraperitoneal injections of saline or DFO
(300mg/kg) for 2 weeks. The animals were submitted to a novel
object recognition task 24h after the last injection.
DFO-treated rats showed normal recognition memory while the
saline group showed long-term recognition memory deficits. The
results show that DFO is able to reverse age- induced
recognition memory deficits. We also demonstrated that DFO
reduced the oxidative damage to proteins in cortex and
hippocampus. Thus, the present findings provide the first
evidence that iron chelators might prevent age-related memory
dysfunction.
PMID: 17346856 [PubMed - as supplied by publisher]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk