Ironjustic
Fri, Mar-09-07, 17:17
Am J Clin Nutr. 2007 Mar;85(3):702-8.Choline-related
supplements improve abnormal plasma methionine-homocysteine
metabolites and glutathione status in children with cystic
fibrosis.Innis SM, Davidson AG, Melynk S, James SJ. Department
of Paediatrics, University of British Columbia, Vancouver, BC,
Canada, and the Department of Pediatrics, University of
Arkansas for Medical Sciences, Little Rock, AR.
BACKGROUND: Liver triacylglycerol accumulation and oxidative
stress are common in cystic fibrosis (CF) and also occur in
choline deficiency. Previously, we showed an association
between elevated plasma homocysteine, reduced ratios of
S-adenosylmethionine to S- adenosylhomocysteine (SAM:SAH) and
of phosphatidylcholine to phosphatidylethanolamine, and
phospholipid malabsorption in children with CF. OBJECTIVE: The
objective was to address a possible relation between altered
methionine-homocysteine metabolism and choline metabolism in
children with CF. DESIGN: Children with CF were assigned
without bias to supplementation with 2 g lecithin/d (n =3D
13), 2 g choline/d (n =3D 12), or 3 g betaine/d (n =3D 10) for
14 d. Plasma concentrations of methionine, adenosine,
cysteine, cysteinyl-glycine, glutathione, glutathione
disulfide (GSSG), and fatty acids; SAM:SAH; and red blood cell
phospholipids were measured within each group of children with
CF before and after supplementation. Plasma from healthy
children without CF (n =3D 15) was analyzed to obtain
reference data. RESULTS: Children with CF had higher plasma
homocysteine, SAH, and adenosine and lower methionine,
SAM:SAH, and glutathione:GSSG than did children without CF.
Supplementation with lecithin, choline, or betaine resulted in
a significant increase in plasma methionine, SAM, SAM:SAH, and
glutathione:GSSG and a decrease in SAH (n =3D 35).
Supplementation with choline or betaine was associated with a
significant decrease in plasma SAH and an increase in SAM:SAH,
methionine, and glutathione:GSSG. Supplementation with
lecithin or choline also increased plasma methionine and SAM.
CONCLUSION: We showed that dietary supplementation with
choline-related compounds improves the low SAM:SAH and
glutathione redox balance in children with CF.
PMID: 17344490 [PubMed - in process]
--------------------------------------------------------------
--------------= =AD=AD=AD----- <<snip>> Lecithin may therefore
be the method of choice for accelerating acetylcholine
synthesis <<snip>>
Lancet. 1977 Jul 9;2(8028):68-9. Related Articles, Links
Lecithin consumption raises serum-free-choline levels.
Wurtman RJ, Hirsch MJ, Growdon JH.
Consumption of choline by rats sequentially increases
serum-choline, brain-choline, and brain-acetylcholine
concentrations. In man consumption of choline increases in
levels in the serum and cerebrospinal fluid; its
administration is an effective way of treating
tardive dyskinesia. We found that oral lecithin is
considerably more effective in raising human serum-choline
levels than an equivalent quantity of choline chloride. 30
minutes after ingestion of choline chloride (2-3 g free base),
serum-choline levels rose by 86% and returned to normal values
within 4 hours; 1 hour after lecithin ingestion, these levels
rose by 265% and remained significantly raised for 12 hours.
Lecithin may therefore be the method of choice for
accelerating acetylcholine synthesis by increasing the
availability of choline, its precursor in the blood.
PMID: 69151 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------
--------------= =AD=AD=AD-----
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
supplements improve abnormal plasma methionine-homocysteine
metabolites and glutathione status in children with cystic
fibrosis.Innis SM, Davidson AG, Melynk S, James SJ. Department
of Paediatrics, University of British Columbia, Vancouver, BC,
Canada, and the Department of Pediatrics, University of
Arkansas for Medical Sciences, Little Rock, AR.
BACKGROUND: Liver triacylglycerol accumulation and oxidative
stress are common in cystic fibrosis (CF) and also occur in
choline deficiency. Previously, we showed an association
between elevated plasma homocysteine, reduced ratios of
S-adenosylmethionine to S- adenosylhomocysteine (SAM:SAH) and
of phosphatidylcholine to phosphatidylethanolamine, and
phospholipid malabsorption in children with CF. OBJECTIVE: The
objective was to address a possible relation between altered
methionine-homocysteine metabolism and choline metabolism in
children with CF. DESIGN: Children with CF were assigned
without bias to supplementation with 2 g lecithin/d (n =3D
13), 2 g choline/d (n =3D 12), or 3 g betaine/d (n =3D 10) for
14 d. Plasma concentrations of methionine, adenosine,
cysteine, cysteinyl-glycine, glutathione, glutathione
disulfide (GSSG), and fatty acids; SAM:SAH; and red blood cell
phospholipids were measured within each group of children with
CF before and after supplementation. Plasma from healthy
children without CF (n =3D 15) was analyzed to obtain
reference data. RESULTS: Children with CF had higher plasma
homocysteine, SAH, and adenosine and lower methionine,
SAM:SAH, and glutathione:GSSG than did children without CF.
Supplementation with lecithin, choline, or betaine resulted in
a significant increase in plasma methionine, SAM, SAM:SAH, and
glutathione:GSSG and a decrease in SAH (n =3D 35).
Supplementation with choline or betaine was associated with a
significant decrease in plasma SAH and an increase in SAM:SAH,
methionine, and glutathione:GSSG. Supplementation with
lecithin or choline also increased plasma methionine and SAM.
CONCLUSION: We showed that dietary supplementation with
choline-related compounds improves the low SAM:SAH and
glutathione redox balance in children with CF.
PMID: 17344490 [PubMed - in process]
--------------------------------------------------------------
--------------= =AD=AD=AD----- <<snip>> Lecithin may therefore
be the method of choice for accelerating acetylcholine
synthesis <<snip>>
Lancet. 1977 Jul 9;2(8028):68-9. Related Articles, Links
Lecithin consumption raises serum-free-choline levels.
Wurtman RJ, Hirsch MJ, Growdon JH.
Consumption of choline by rats sequentially increases
serum-choline, brain-choline, and brain-acetylcholine
concentrations. In man consumption of choline increases in
levels in the serum and cerebrospinal fluid; its
administration is an effective way of treating
tardive dyskinesia. We found that oral lecithin is
considerably more effective in raising human serum-choline
levels than an equivalent quantity of choline chloride. 30
minutes after ingestion of choline chloride (2-3 g free base),
serum-choline levels rose by 86% and returned to normal values
within 4 hours; 1 hour after lecithin ingestion, these levels
rose by 265% and remained significantly raised for 12 hours.
Lecithin may therefore be the method of choice for
accelerating acetylcholine synthesis by increasing the
availability of choline, its precursor in the blood.
PMID: 69151 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------
--------------= =AD=AD=AD-----
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk