Ironjustic
Sun, Jan-21-07, 17:16
Association between higher cumulative doses of recombinant
erythropoietin and risk for retinopathy of prematurity. Brown
MS, Bar=F3n AE, France EK, Hamman RF J AAPOS. 2006 Apr ;
10(2): 143-9
BACKGROUND: Retinopathy of prematurity is a complication of
premature birth that varies in its severity. The incidence and
severity of retinopathy of prematurity at our perinatal center
in a regional referral hospital changed substantially during
1995 to 1998 and presented us with an opportunity to examine
whether there was a protective effect on risk of retinopathy
associated with exposure to recombinant erythropoietin.
METHODS: We undertook a retrospective cohort study. From
January 1995 through December 1998, charts of infants
weighing<1500 g, who were 30 weeks' gestation or less, and who
were admitted and survived to the first eye examination at 6
weeks were reviewed. Primary and secondary risk factors were
recorded from the first 6 weeks of life. Of the eligible
infants, 327 of 390 (84%) had complete records and retinal
examinations. The probability for progression of retinopathy
was estimated by logistic regression multivariate analysis
using the continuation-ratio model. RESULTS: The overall
incidence of retinopathy of prematurity was 36%. Recombinant
erythropoietin exposure, as total 6-week dose, was
independently associated with an increased risk for
progression of retinopathy, OR=3D1.27 per 500 units/kg
(95%CI=3D1.04, 1.55, P=3D0.02). Postnatal day of recombinant
erythropoietin initiation also was associated with retinopathy
risk but did not reach conventional statistical significance,
OR=3D1.07 (CI=3D1.00, 1.14, P=3D0.07). CONCLUSIONS: These
findings identify an association between cumulative
recombinant erythropoietin exposure, used to reduce blood
transfusions in premature infants, and an increased risk for
retinopathy of prematurity. The nonhematopoietic properties of
erythropoietin may account for the above findings, however
further evaluation with confirmation is required.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk
erythropoietin and risk for retinopathy of prematurity. Brown
MS, Bar=F3n AE, France EK, Hamman RF J AAPOS. 2006 Apr ;
10(2): 143-9
BACKGROUND: Retinopathy of prematurity is a complication of
premature birth that varies in its severity. The incidence and
severity of retinopathy of prematurity at our perinatal center
in a regional referral hospital changed substantially during
1995 to 1998 and presented us with an opportunity to examine
whether there was a protective effect on risk of retinopathy
associated with exposure to recombinant erythropoietin.
METHODS: We undertook a retrospective cohort study. From
January 1995 through December 1998, charts of infants
weighing<1500 g, who were 30 weeks' gestation or less, and who
were admitted and survived to the first eye examination at 6
weeks were reviewed. Primary and secondary risk factors were
recorded from the first 6 weeks of life. Of the eligible
infants, 327 of 390 (84%) had complete records and retinal
examinations. The probability for progression of retinopathy
was estimated by logistic regression multivariate analysis
using the continuation-ratio model. RESULTS: The overall
incidence of retinopathy of prematurity was 36%. Recombinant
erythropoietin exposure, as total 6-week dose, was
independently associated with an increased risk for
progression of retinopathy, OR=3D1.27 per 500 units/kg
(95%CI=3D1.04, 1.55, P=3D0.02). Postnatal day of recombinant
erythropoietin initiation also was associated with retinopathy
risk but did not reach conventional statistical significance,
OR=3D1.07 (CI=3D1.00, 1.14, P=3D0.07). CONCLUSIONS: These
findings identify an association between cumulative
recombinant erythropoietin exposure, used to reduce blood
transfusions in premature infants, and an increased risk for
retinopathy of prematurity. The nonhematopoietic properties of
erythropoietin may account for the above findings, however
further evaluation with confirmation is required.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk