Paul Anton
Fri, Jan-19-07, 06:18
Notice of Joint Bulk Purchase of >99% Resveratrol
Participants are being sought for a joint bulk purchase of
>99% pure fully synthetic trans-resveratrol from the exact
same company (Orchid Chemicals and Pharmaceuticals Ltd of
Chennai, India) that supplied the resveratrol used in the last
two major published mouse feeding studies
http://pmid.us/17086191 http://pmid.us/17112576. In these
studies trans-resveratrol, at human equivalent daily dosages
of 5 and 50 mg/kg respectively, was shown to have major
beneficial effects as a calorie restriction mimetic, and on
enhanced mitochondrial activity resulting in more energy and
stamina respectively. The pure synthetic has the advantage
that it is completely free from plant contaminants which may
have negative effects, while being exactly the same chemical
as occurs in nature in red wine (among other sources). In
order to obtain a supply of trans-resveratrol for myself and
other interested parties, I am seeking others to join me in a
large bulk purchase so that together we may get the far lower
price per gram that the supplier will give for a large order.
I have already successfully received and distributed to the
initial joint purchase participants 4 kg from Orchid which is
in the process of producing a large new batch to be ready by
mid March 2007. This notice is for the purpose of increasing
the amount that will be ordered at that time, if anyone should
be interested.
Here are the terms of this add-on commitment for new joint
bulk purchase participants.
Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007
Pricing
100 grams @ $4.00 per gram, 200 grams @ $3.65 per gram, 300
grams @ $3.40 per gram, 400 grams @ $3.25 per gram, 500 grams
@ $3.15 per gram.
Packaging
All purchases are packaged in 50 or 100 gm amounts in
polypropylene (PP) zip-lock bags with all air expelled before
the bag is closed. PP bags are much more moisture and air
proof than are polyethylene (PE) bags (the standard that one
gets at the supermarket). Each PP bag is placed in a zip-lock
PE sandwich bag for added protection. Multiple bags are then
placed into a bubble envelope which is then placed inside a
USPS flat rate priority mail envelope for shipments of 200
grams or less and a priority box for more than that. (For
those outside the US things will be done a little differently
as appropriate to your import needs.)
Storage, handling and Dosage
If the bags are kept in a freezer (all processes are slower at
a lower temperature), and inside a light proof container (dark
bottle or HDPE container), then research, reading and
discussions with others suggests that there will be little
degradation over a period of 2 years. The mice researchers
stated nothing about storage in nitrogen during the experiment
and most of the storage time was in a refrigerator mixed with
chow. During actual usage everyone would be wise to expel all
air from the bag whenever it is reclosed after getting some
out of it.
When you remove some resveratrol from a larger package, only
remove enough to last for, say, ten days or 2 weeks at a time
and, when not in use, keep it in a small PP ziplock bag in a
dark bottle in the refrigerator. Small PP zip-lock bags will
be enclosed with every shipment package for the purpose of
keeping this smaller in-use amount in the refrigerator.
As for dosage, standard dosage increasing procedures for any
new chemical suggests that it will be safest to start at 0.5
mg/kg daily and double every 2 weeks until you reach at least
5 mg/kg (which is what Dr David Sinclair takes and what I am
taking), but this is really a matter of individual choice and
desire for experimentation. With respect to upper limits of
dosage, note that there is no evidence of toxicity for
resveratrol even at a human equivalent dosage of 75 mg/kg
- http://pmid.us/15329443.
Shipping and payment
All prices include priority mail (USPS) shipping to US
addresses and a copy of the Certificate of Analysis (COA) of
the product. Insurance of package costs extra. Out of US
shipping incurs a $25 surcharge (only $15 to Canada) with no
customs entry guarantees. Email me your full legal name,
physical and postal addresses, phone number and amount
desired. Be prepared to pay in advance by check or money
order in early March when the next order with Orchid will
need to be placed and prepaid, since this is a joint bulk
purchase and must be prepaid. I will email you when I need
prepayment in March.
Responsibility for Loss
Everyone should be aware that although all joint purchasers
received their allotted share of the first partial shipment,
there is always some possibility that an entire future
shipment, or merely a shipment to a particular joint
purchaser, will be lost. Although as the coordinator of this
prepaid joint bulk purchase I promise to do everything that I
possibly can to prevent any such loss, I do not bear any
responsibility for refunding any money in the case of any
such loss.
--Paul Wakfer
MoreLife for the rational - http://morelife.org Reality based
tools for more life in quantity and quality The Self-Sovereign
Individual Project - http://selfsip.org Rational freedom by
self-sovereignty & social contracting
Participants are being sought for a joint bulk purchase of
>99% pure fully synthetic trans-resveratrol from the exact
same company (Orchid Chemicals and Pharmaceuticals Ltd of
Chennai, India) that supplied the resveratrol used in the last
two major published mouse feeding studies
http://pmid.us/17086191 http://pmid.us/17112576. In these
studies trans-resveratrol, at human equivalent daily dosages
of 5 and 50 mg/kg respectively, was shown to have major
beneficial effects as a calorie restriction mimetic, and on
enhanced mitochondrial activity resulting in more energy and
stamina respectively. The pure synthetic has the advantage
that it is completely free from plant contaminants which may
have negative effects, while being exactly the same chemical
as occurs in nature in red wine (among other sources). In
order to obtain a supply of trans-resveratrol for myself and
other interested parties, I am seeking others to join me in a
large bulk purchase so that together we may get the far lower
price per gram that the supplier will give for a large order.
I have already successfully received and distributed to the
initial joint purchase participants 4 kg from Orchid which is
in the process of producing a large new batch to be ready by
mid March 2007. This notice is for the purpose of increasing
the amount that will be ordered at that time, if anyone should
be interested.
Here are the terms of this add-on commitment for new joint
bulk purchase participants.
Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007
Pricing
100 grams @ $4.00 per gram, 200 grams @ $3.65 per gram, 300
grams @ $3.40 per gram, 400 grams @ $3.25 per gram, 500 grams
@ $3.15 per gram.
Packaging
All purchases are packaged in 50 or 100 gm amounts in
polypropylene (PP) zip-lock bags with all air expelled before
the bag is closed. PP bags are much more moisture and air
proof than are polyethylene (PE) bags (the standard that one
gets at the supermarket). Each PP bag is placed in a zip-lock
PE sandwich bag for added protection. Multiple bags are then
placed into a bubble envelope which is then placed inside a
USPS flat rate priority mail envelope for shipments of 200
grams or less and a priority box for more than that. (For
those outside the US things will be done a little differently
as appropriate to your import needs.)
Storage, handling and Dosage
If the bags are kept in a freezer (all processes are slower at
a lower temperature), and inside a light proof container (dark
bottle or HDPE container), then research, reading and
discussions with others suggests that there will be little
degradation over a period of 2 years. The mice researchers
stated nothing about storage in nitrogen during the experiment
and most of the storage time was in a refrigerator mixed with
chow. During actual usage everyone would be wise to expel all
air from the bag whenever it is reclosed after getting some
out of it.
When you remove some resveratrol from a larger package, only
remove enough to last for, say, ten days or 2 weeks at a time
and, when not in use, keep it in a small PP ziplock bag in a
dark bottle in the refrigerator. Small PP zip-lock bags will
be enclosed with every shipment package for the purpose of
keeping this smaller in-use amount in the refrigerator.
As for dosage, standard dosage increasing procedures for any
new chemical suggests that it will be safest to start at 0.5
mg/kg daily and double every 2 weeks until you reach at least
5 mg/kg (which is what Dr David Sinclair takes and what I am
taking), but this is really a matter of individual choice and
desire for experimentation. With respect to upper limits of
dosage, note that there is no evidence of toxicity for
resveratrol even at a human equivalent dosage of 75 mg/kg
- http://pmid.us/15329443.
Shipping and payment
All prices include priority mail (USPS) shipping to US
addresses and a copy of the Certificate of Analysis (COA) of
the product. Insurance of package costs extra. Out of US
shipping incurs a $25 surcharge (only $15 to Canada) with no
customs entry guarantees. Email me your full legal name,
physical and postal addresses, phone number and amount
desired. Be prepared to pay in advance by check or money
order in early March when the next order with Orchid will
need to be placed and prepaid, since this is a joint bulk
purchase and must be prepaid. I will email you when I need
prepayment in March.
Responsibility for Loss
Everyone should be aware that although all joint purchasers
received their allotted share of the first partial shipment,
there is always some possibility that an entire future
shipment, or merely a shipment to a particular joint
purchaser, will be lost. Although as the coordinator of this
prepaid joint bulk purchase I promise to do everything that I
possibly can to prevent any such loss, I do not bear any
responsibility for refunding any money in the case of any
such loss.
--Paul Wakfer
MoreLife for the rational - http://morelife.org Reality based
tools for more life in quantity and quality The Self-Sovereign
Individual Project - http://selfsip.org Rational freedom by
self-sovereignty & social contracting