Nancy LC
Wed, Dec-27-06, 09:29
http://www.sciam.com/article.cfm?chanID=sa003&articleID=C055A20E-E7F2-99DF-3D3D2252606AAAC8
Helps to have the right gene:
[snippet]
If you live to 100, as roughly one in every 10,000 people do, you will likely want both your mind and body intact. Researchers have now discovered a gene that accomplishes just that, apparently protecting the brain as well as prolonging life.
The Longevity Genes Project, initiated by Nir Barzilai, director of the Institute for Aging Research at Albert Einstein College of Medicine, investigates people who live exceptionally long lives.
"There's a strong family history of longevity in these people," says Barzilai. "Research has shown the odds of having exceptional longevity are about 10 to 18 times more if you have a centenarian in your family. And these usually aren't vegetarians or professional athletes. Some have smoked for 90 years."
...
The CETP gene variant makes cholesterol particles in the blood larger than normal. The researchers suggest smaller particles can more readily lodge in the lining of blood vessels, leading to fatty buildups, which are a risk factor for heart attacks and strokes.
Whether or not this gene variant protects the brain by preventing this buildup, or through some other mechanism, remains uncertain, says Barzilai. Future research should also investigate whether this gene has an effect on dementia associated with Alzheimer's disease, says pathologist and human geneticist George Martin at the University of Washington.
Helps to have the right gene:
[snippet]
If you live to 100, as roughly one in every 10,000 people do, you will likely want both your mind and body intact. Researchers have now discovered a gene that accomplishes just that, apparently protecting the brain as well as prolonging life.
The Longevity Genes Project, initiated by Nir Barzilai, director of the Institute for Aging Research at Albert Einstein College of Medicine, investigates people who live exceptionally long lives.
"There's a strong family history of longevity in these people," says Barzilai. "Research has shown the odds of having exceptional longevity are about 10 to 18 times more if you have a centenarian in your family. And these usually aren't vegetarians or professional athletes. Some have smoked for 90 years."
...
The CETP gene variant makes cholesterol particles in the blood larger than normal. The researchers suggest smaller particles can more readily lodge in the lining of blood vessels, leading to fatty buildups, which are a risk factor for heart attacks and strokes.
Whether or not this gene variant protects the brain by preventing this buildup, or through some other mechanism, remains uncertain, says Barzilai. Future research should also investigate whether this gene has an effect on dementia associated with Alzheimer's disease, says pathologist and human geneticist George Martin at the University of Washington.