Hearing loss / lecithin

[Ironjustic]

Otolaryngol Head Neck Surg (2002) 127: 138-44.

Influence of lecithin on mitochondrial DNA and age-related
hearing loss.

MD Seidman, MJ Khan, WX Tang, WS Quirk Department of
Otolaryngology-Head and Neck Surgery, Henry Ford Health
System, West Bloomfield., MI 48323, USA. Mseidma1@hfhs.org
OBJECTIVES: Lecithin is a polyunsaturated phosphatidylcholine
(PPC), which are high energy functional and structural
elements of all biologic membranes. PPC play a rate-limiting
role in the activation of numerous membrane-located enzymes,
including superoxide dismutase and glutathione, which are
important antioxidants protecting cell membranes from damage
by reactive oxygen species (ROS). ROS-induced damage to
mitochondrial DNA may lead to reduced mitochondrial function
in the cochlea and resultant hearing loss. STUDY DESIGN AND
SETTING: The effects of lecithin on aging and age-associated
hearing loss were studied in rats by measuring hearing
sensitivities using auditory brainstem responses (ABR). In
addition, mitochondrial function as a measure of aging was
assessed by determining mitochondrial membrane potentials
using flow cytometry and by amplifying mitochondrial DNA
deletions associated with aging. Harlan-Fischer rats aged 18
to 20 months (n = 14) were divided into 2 groups. The
experimental group was supplemented orally for 6 months with
lecithin, a purified extract of soybean phospholipid
(Nutritional Therapeutics, Allendale, NJ). RESULTS: The data
obtained were compared with the control group. ABRs were
recorded at 2-month intervals and showed significant
preservation of hearing sensitivities in the treated subjects.
Flow cytometry revealed significantly higher mitochondrial
membrane potentials in the treated subjects, suggesting
preserved mitochondrial function. Finally, the common aging
mitochondrial DNA deletion (mtDNA(4834)) were amplified from
brain and cochlear tissue including stria vascularis and
auditory nerve. This specific deletion was found significantly
less frequent in all tissues in the treated group compared
with the controls. CONCLUSION: These experiments support our
hypothesis and provide evidence that lecithin may preserve
cochlear mitochondrial function and protect hearing loss
associated with aging.

Who loves ya. Tom

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Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[Ianw]

> MD Seidman, MJ Khan, WX Tang, WS Quirk Department of
> Otolaryngology-Head and Neck Surgery, Henry Ford Health
> System, West Bloomfield., MI 48323, USA. Mseidma1@hfhs.org
> OBJECTIVES: Lecithin is a polyunsaturated
> phosphatidylcholine (PPC), which are high energy functional
> and structural elements of all biologic membranes. PPC play
> a rate-limiting role in the activation of numerous
> membrane-located enzymes, including superoxide dismutase
> and glutathione, which are important antioxidants
> protecting cell membranes from damage by reactive oxygen
> species (ROS). ROS-induced damage to mitochondrial DNA may
> lead to reduced mitochondrial function in the cochlea and
> resultant hearing loss.

Interesting. I have CFS but also, more unusually (for a 38 yr
old), hearing loss. CFS has been associated with reduced
mitochondrial function but this is the first time I've heard
that for hearing loss, yet I've always suspected the two were
linked (for me that is - hearing loss isn't a CFS symptom)
since my hearing loss first started becoming noticable about a
year prior to my CFS diagnosis.

Am going to look into lecithin now. Thanks for posting this.

IanW

[Vernon]

"IanW" <whoami@whereami.net> wrote in message
news:haydnULUv6IgZvrYnZ2dnUVZ8tOdnZ2d@pipex.net...
>> MD Seidman, MJ Khan, WX Tang, WS Quirk Department of
>> Otolaryngology-Head and Neck Surgery, Henry Ford Health
>> System, West Bloomfield., MI 48323, USA. Mseidma1@hfhs.org
>> OBJECTIVES: Lecithin is a polyunsaturated
>> phosphatidylcholine (PPC), which are high energy functional
>> and structural elements of all biologic membranes. PPC play
>> a rate-limiting role in the activation of numerous
>> membrane-located enzymes, including superoxide dismutase
>> and glutathione, which are important antioxidants
>> protecting cell membranes from damage by reactive oxygen
>> species (ROS). ROS-induced damage to mitochondrial DNA may
>> lead to reduced mitochondrial function in the cochlea and
>> resultant hearing loss.
>
> Interesting. I have CFS but also, more unusually (for a 38
> yr old), hearing loss. CFS has been associated with reduced
> mitochondrial function but this is the first time I've heard
> that for hearing loss, yet I've always suspected the two
> were linked (for me that is - hearing loss isn't a CFS
> symptom) since my hearing loss first started becoming
> noticable about a year prior to my CFS diagnosis.
>
> Am going to look into lecithin now. Thanks for posting this.
>
> IanW
>
CFS is a symptom. It is a "symptom" of another malady physical
or mental. If mental, it can be caused by something physical.
Hearing loss can be a physical problem with hearing loss being
a symptom.

So Hearing loss cannot be a CFS symptom any more than a
tooth ache.

Now then, phosphatidylcholine dilutes (breaks down) fat
deposits. Fat deposits often cause circulation problems, thus
CFS

CAUTION MANY MANY MANY people end up in the hospital or dead
because of the simplistic diagnoses of a non-disease called
CFS. Heart insufficiency is heart insufficiency and often
precedes a heart attack (especially in the young) (AKA, He's
too young and healthy to have HEART problems)

[Ianw]

"vernon" <here@there> wrote in message
news:4568536a$0$23307$88260bb3@news.teranews.com...

> So Hearing loss cannot be a CFS symptom any more than a
> tooth ache.

yes, what I mean is that I reckon that my hearing loss is
connected to whatever also caused my CFS

> Now then, phosphatidylcholine dilutes (breaks down) fat
> deposits. Fat deposits often cause circulation problems,
> thus CFS
>
> CAUTION MANY MANY MANY people end up in the hospital or dead
> because of the simplistic diagnoses of a non-disease called
> CFS. Heart insufficiency is heart insufficiency and often
> precedes a heart attack (especially in the young) (AKA, He's
> too young and healthy to have HEART problems)

there is a theory that mitochondrial failure leads to a form
of heart failure in CFS
(http://www.drmyhill.co.uk/article.cfm?id=381 - half way
down). You could be right about fat despites but then there
has been a lot of research into CFS and I haven't noticed any
of the invesigating teams spotting fatty despoit build up. I
had all the standard heart tests don prior to the hospital
diagnosing CFS and everything was normal, but of course they
didn't check for fatty deposits.

IanW

[Vernon]

"IanW" <whoami@whereami.net> wrote in message
news:45687bca.0@entanet...
> "vernon" <here@there> wrote in message
> news:4568536a$0$23307$88260bb3@news.teranews.com...
>
>> So Hearing loss cannot be a CFS symptom any more than a
>> tooth ache.
>
> yes, what I mean is that I reckon that my hearing loss is
> connected to whatever also caused my CFS
>
>> Now then, phosphatidylcholine dilutes (breaks down) fat
>> deposits. Fat deposits often cause circulation problems,
>> thus CFS
>>
>> CAUTION MANY MANY MANY people end up in the hospital or
>> dead because of the simplistic diagnoses of a non-disease
>> called CFS. Heart insufficiency is heart insufficiency and
>> often precedes a heart attack (especially in the young)
>> (AKA, He's too young and healthy to have HEART problems)
>
> there is a theory that mitochondrial failure leads to a form
> of heart failure in CFS
> (http://www.drmyhill.co.uk/article.cfm?id=381 - half way
> down). You could be right about fat despites but then there
> has been a lot of research into CFS and I haven't noticed
> any of the invesigating teams spotting fatty despoit build
> up. I had all the standard heart tests don prior to the
> hospital diagnosing CFS and everything was normal, but of
> course they didn't check for fatty deposits.
>
> IanW
>

I could go on about theory. I am giving statistics of young
people who end up in the hospital or dead after MANY doctors
diagnosed CFS. A basic in CFS is some sort of unknown
insufficiency. When you say ALL the standard heart tests, did
it include an angiogram and a ejection test? What is your
ejection coefficient? Don't get me wrong there are many causes
of CFS. Another that isn't as dangerous and really difficult
to determine is an electrical problem in the system or the
brain. Guess what? Phosphatidylcholine can sometimes help. The
brain is very dependant on good Cholesterol.

[Ianw]

"Vernon" <anere@anhere> wrote in message
news:45688f22$0$17469$882e0bbb@news.ThunderNews.com...

> I could go on about theory. I am giving statistics of young
> people who end up in the hospital or dead after MANY doctors
> diagnosed CFS. A basic in CFS is some sort of unknown
> insufficiency. When you say ALL the standard heart tests,
> did it include an angiogram and a ejection test? What is
> your ejection coefficient?

well, all the tests the heart specialist at the hospital saw
fit to do. There was an exercise ECG, tilt test and a 24-hour
ECG thing.. I think there was another but I can't remember
(x-ray? - whatever it is that looks for an enlarged heart
anyway). Don't think I had angiogram or ejection though.

> Don't get me wrong there are many causes of CFS. Another
> that isn't as dangerous and really difficult to determine is
> an electrical problem in the system or the brain. Guess
> what? Phosphatidylcholine can sometimes help. The brain is
> very dependant on good Cholesterol.

well, I've decided to try it.. 1.3gms lecithin along with 1gm
Vit C & 1gm Lysine (the latter 2 being a combo Linus Pauling
recommended), 3 times a day. Will see how it goes.

Regards IanW

[Vernon]

"IanW" <whoami@whereami.net> wrote in message
news:4569759d.0@entanet...
>
> "Vernon" <anere@anhere> wrote in message
> news:45688f22$0$17469$882e0bbb@news.ThunderNews.com...
>
>> I could go on about theory. I am giving statistics of young
>> people who end up in the hospital or dead after MANY
>> doctors diagnosed CFS. A basic in CFS is some sort of
>> unknown insufficiency. When you say ALL the standard heart
>> tests, did it include an angiogram and a ejection test?
>> What is your ejection coefficient?
>
> well, all the tests the heart specialist at the hospital saw
> fit to do. There was an exercise ECG, tilt test and a
> 24-hour ECG thing.. I think there was another but I can't
> remember (x-ray? - whatever it is that looks for an enlarged
> heart anyway).

I passed EVERY ONE of those test with the results as if an
athlete. I had a massive heart attack and lost a third of my
heart within three weeks of the tests. My heart was slightly
enlarged and was considered due to my level of exercise
(dancing 6 nights a week for two hours) When I came around, I
asked why I had such a thing when I was following all the
rules. The answer was that I would NEVER have survived had I
not been in good physical condition.

>Don't think I had angiogram or ejection though.
>
>> Don't get me wrong there are many causes of CFS. Another
>> that isn't as dangerous and really difficult to determine
>> is an electrical problem in the system or the brain. Guess
>> what? Phosphatidylcholine can sometimes help. The brain is
>> very dependant on good Cholesterol.
>
> well, I've decided to try it.. 1.3gms lecithin along with
> 1gm Vit C & 1gm Lysine (the latter 2 being a combo Linus
> Pauling recommended), 3 times a day. Will see how it goes.

It would be difficult to think of a better regimine. Don't
forget your execise.

>
> Regards IanW

[Ianw]

"Vernon" <anere@anhere> wrote in message
news:4569ed82$0$17456$882e0bbb@news.ThunderNews.com...
> I passed EVERY ONE of those test with the results as if an
> athlete. I had a massive heart attack and lost a third of my
> heart within three weeks of the tests. My heart was slightly
> enlarged and was considered due to my level of exercise
> (dancing 6 nights a week for two hours) When I came around,
> I asked why I had such a thing when I was following all the
> rules. The answer was that I would NEVER have survived had I
> not been in good physical condition.

that sounds terrible. glad to see you survived though. I take
it the cause was a blocked artery? I note there is some
interesting research going on into the area of the heart
repairing itself
(http://news.bbc.co.uk/1/hi/health/6143286.stm). I guess it
will take a good few years for anything to come of it but it's
encouraging.

> It would be difficult to think of a better regimine. Don't
> forget your execise.

that's tricky with CFS.. one of the big factors about CFS is
that exercise can do more harm than good. if I do anything
more aerobic than walking I get tight chested and lots of
general malaise and fatigue that can take hours or even a day
to get over. I must do more walking though, as I can manage a
reasonable amount of that.

IanW

[Vernon]

"IanW" <whoami@whereami.com> wrote in message
news:ekh9bi$lbc$1@south.jnrs.ja.net...
> "Vernon" <anere@anhere> wrote in message
> news:4569ed82$0$17456$882e0bbb@news.ThunderNews.com...
>> I passed EVERY ONE of those test with the results as if an
>> athlete. I had a massive heart attack and lost a third of
>> my heart within three weeks of the tests. My heart was
>> slightly enlarged and was considered due to my level of
>> exercise (dancing 6 nights a week for two hours) When I
>> came around, I asked why I had such a thing when I was
>> following all the rules. The answer was that I would NEVER
>> have survived had I not been in good physical condition.
>
> that sounds terrible. glad to see you survived though. I
> take it the cause was a blocked artery? I note there is some
> interesting research going on into the area of the heart
> repairing itself
> (http://news.bbc.co.uk/1/hi/health/6143286.stm). I guess it
> will take a good few years for anything to come of it but
> it's encouraging.

Dead flesh (scar tissue) is dead flesh, but yes there are many
ways the heart can repair "damaged" or "weakened" muscle. That
research has been going on for about 40 years. EVERY one of
them includes unusual amounts of supplements.

>
>> It would be difficult to think of a better regimine. Don't
>> forget your execise.
>
> that's tricky with CFS.. one of the big factors about CFS is
> that exercise can do more harm than good. if I do anything
> more aerobic than walking I get tight chested and lots of
> general malaise and fatigue that can take hours or even a
> day to get over. I must do more walking though, as I can
> manage a reasonable amount of that.
>
> IanW

Then just walk. Without exercise just below your limits, you
will only get worse.

I would challenge ANY doctor who sluffs off tightness in the
chest from moderate exercise as ANYTHING but a critical
PHYSICAL problem.