Ironjustic
Thu, Nov-23-06, 17:15
SESAME OIL ATTENUATES ACUTE IRON-INDUCED LIPID
PEROXIDATION-ASSOCIATED HEPATIC DAMAGE IN MICE. Hsu DZ, Chen
KT, Chien SP, Li YH, Huang BM, Chuang YC, Liu MY Shock. 2006
Dec ; 26(6): 625-630
ABSTRACT: Acute iron intoxication from the accidental
ingestion of iron-containing preparations is one important
cause of death in children. The aim of this study was to
investigate the protective effect of sesame oil on acute
iron-induced lipid peroxidation (LPO) and hepatic injury in
mice. Acute iron intoxication was induced by giving ferric
nitrilotriacetate to mice. Hepatic function was assessed using
blood biochemistry. Free radicals were determined using a
high-performance chemiluminescence analyzer. Ferric
nitrilotriacetate increased serum ferrous (Fe) and LPO levels,
and induced acute hepatic injury. Sesame oil (a)
dose-dependently decreased acute iron-induced LPO and hepatic
injury, (b) reduced acute iron-associated hydroxyl radical and
superoxide anion generation, and (c) inhibited the activity of
xanthine oxidase in acute iron in toxication. Thus, sesame oil
might ameliorate LPO and acute hepatic injury by inhibiting
xanthine oxidase-initiated superoxide anion generation,
thereby reducing hydroxyl radical production, at least
partially, in acutely iron-intoxicated mice.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
PEROXIDATION-ASSOCIATED HEPATIC DAMAGE IN MICE. Hsu DZ, Chen
KT, Chien SP, Li YH, Huang BM, Chuang YC, Liu MY Shock. 2006
Dec ; 26(6): 625-630
ABSTRACT: Acute iron intoxication from the accidental
ingestion of iron-containing preparations is one important
cause of death in children. The aim of this study was to
investigate the protective effect of sesame oil on acute
iron-induced lipid peroxidation (LPO) and hepatic injury in
mice. Acute iron intoxication was induced by giving ferric
nitrilotriacetate to mice. Hepatic function was assessed using
blood biochemistry. Free radicals were determined using a
high-performance chemiluminescence analyzer. Ferric
nitrilotriacetate increased serum ferrous (Fe) and LPO levels,
and induced acute hepatic injury. Sesame oil (a)
dose-dependently decreased acute iron-induced LPO and hepatic
injury, (b) reduced acute iron-associated hydroxyl radical and
superoxide anion generation, and (c) inhibited the activity of
xanthine oxidase in acute iron in toxication. Thus, sesame oil
might ameliorate LPO and acute hepatic injury by inhibiting
xanthine oxidase-initiated superoxide anion generation,
thereby reducing hydroxyl radical production, at least
partially, in acutely iron-intoxicated mice.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk