Ironjustic
Mon, Nov-20-06, 17:16
Antioxidant effect of bisphosphonates and simvastatin on
chondrocyte lipid peroxidation. Dombrecht EJ, De Tollenaere
CB, Aerts K, Cos P, Schuerwegh AJ, Bridts CH, Van Offel JF,
Ebo DG, Stevens WJ, De Clerck LS Biochem Biophys Res Commun.
2006 Sep 22; 348(2): 459-64
The objective of this study was to evaluate the effect of
bisphosphonates (BPs) and simvastatin on chondrocyte lipid
peroxidation. For this purpose, a flow cytometrical method
using C11-BODIPY(581/591) was developed to detect
hydroperoxide-induced lipid peroxidation in chondrocytes.
Tertiary butylhydroperoxide (t-BHP) induced a time and
concentration dependent increase in chondrocyte lipid
peroxidation. Addition of a Fe2+/EDTA complex to t-BHP or
hydrogen peroxide (H2O2) clearly enhanced lipid peroxidation.
The lipophilic simvastatin demonstrated a small inhibition in
the chondrocyte lipid peroxidation. None of three tested BPs
(clodronate, pamidronate, and risedronate) had an effect on
chondrocyte lipid peroxidation induced by t-BHP. However, when
Fe2+/EDTA complex was added to t-BHP or H2O2, BPs inhibited
the lipid peroxidation process varying from 25% to 58%. This
study demonstrates that BPs have antioxidant properties as
iron chelators, thereby inhibiting the chondrocyte lipid
peroxidation. These findings add evidence to the therapeutic
potential of bisphosphonates and statins in rheumatoid
arthritis.
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Bisphosphonates : CancerbackupInformation about
bisphosphonates which are used to help protect bones against
some of the effects of cancer particularly myeloma, breast
cancer and ... www.cancerbackup.org.uk/Treatments/Supportivet-
herapies/Bisphosphonates
BisphosphonatesBisphosphonates Bisphosphonates are a family of
drugs used to prevent and treat osteoporosis. There are three
bisphosphonates currently approved for use in ... www.osteopo-
rosis.ca/english/About%20Osteoporosis/Drug%20Treatments/Bisph-
osphonates/default.asp?s=1
- 28k -
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Ironjustic
Wed, Nov-22-06, 06:15
ironjustice@aol.com wrote:
> Antioxidant effect of bisphosphonates and simvastatin on
> chondrocyte lipid peroxidation. Dombrecht EJ, De Tollenaere
> CB, Aerts K, Cos P, Schuerwegh AJ, Bridts CH, Van Offel JF,
> Ebo DG, Stevens WJ, De Clerck LS Biochem Biophys Res Commun.
> 2006 Sep 22; 348(2): 459-64
>
> The objective of this study was to evaluate the effect of
> bisphosphonates (BPs) and simvastatin on chondrocyte lipid
> peroxidation. For this purpose, a flow cytometrical method
> using C11-BODIPY(581/591) was developed to detect
> hydroperoxide-induced lipid peroxidation in chondrocytes.
> Tertiary butylhydroperoxide (t-BHP) induced a time and
> concentration dependent increase in chondrocyte lipid
> peroxidation. Addition of a Fe2+/EDTA complex to t-BHP or
> hydrogen peroxide (H2O2) clearly enhanced lipid
> peroxidation. The lipophilic simvastatin demonstrated a
> small inhibition in the chondrocyte lipid peroxidation. None
> of three tested BPs (clodronate, pamidronate, and
> risedronate) had an effect on chondrocyte lipid peroxidation
> induced by t-BHP. However, when Fe2+/EDTA complex was added
> to t-BHP or H2O2, BPs inhibited the lipid peroxidation
> process varying from 25% to 58%. This study demonstrates
> that BPs have antioxidant properties as iron chelators,
> thereby inhibiting the chondrocyte lipid peroxidation. These
> findings add evidence to the therapeutic potential of
> bisphosphonates and statins in rheumatoid arthritis.
>
> ----------------------------------------------------------
> --------
>
> Bisphosphonates : CancerbackupInformation about
> bisphosphonates which are used to help protect bones against
> some of the effects of cancer particularly myeloma, breast
> cancer and ... www.cancerbackup.org.uk/Treatments/Supportiv-
> etherapies/Bisphosphonates
>
>
> BisphosphonatesBisphosphonates Bisphosphonates are a family
> of drugs used to prevent and treat osteoporosis. There are
> three bisphosphonates currently approved for use in ... www-
> .osteoporosis.ca/english/About%20Osteoporosis/Drug%20Treatm-
> ents/Bispho=
sphonates/default.asp?s=3D1
> - 28k -
>
>
> Who loves ya. Tom
>
>
> Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore! http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Risedronate is the latest of the bisphosphonates to be used
for the management of resorptive bone disease. Clinical
improvements, assessed by the incidence ...
www.medscape.com/viewarticle/414905
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Source: Johns Hopkins Medical Institutions Released: Tue
21-Nov-2006, 16:00 ET Printer-friendly Version
Millions with Arthritis May Benefit from Bone Loss Drug
Libraries Medical News Keywords ARTHRITIS BONE LOSS
RHEUMATOLOGY OSTEOPOROSIS OSTEOARTHRITIS Contact Information
Available for logged-in reporters only Description
People taking a widely used medication to strengthen fragile,
aging bones may also be protecting their joints, according to
a recent study led by Johns Hopkins rheumatologist Clifton
Bingham, M.D.
Newswise - People taking a widely used medication to
strengthen fragile, aging bones may also be protecting their
joints, according to a recent study led by Johns Hopkins
rheumatologist Clifton Bingham, M=2ED.
Researchers began to wonder if risedronate might be used to
treat osteoarthritis after noticing that the drug, and other
compounds in the same class of drugs, not only slowed joint
damage in animals, but also reduced cartilage-irritating bone
lesions in humans.
For two years, an international team of investigators studied
2,483 arthritic men and women, from both the United States and
Europe. All of those enrolled in the study had a loss in the
cartilage that cushions the knee joint, a hallmark symptom of
osteoarthritis.
Reporting in the most recent issue of the medical journal
Arthritis & Rheumatism, Bingham and his team said study
participants were given either a placebo or risedronate at a
range of doses, including the standard doses normally
prescribed to treat bone loss. The amount of cartilage
detected in their knees was measured by X-ray analysis at the
one- and two-year marks. Blood tests were also used to check
for a marker of cartilage breakdown known as CTX-II.
CTX-II is released in the bloodstreams of people with
osteoarthritis when cartilage begins to fray. How fast and to
what degree cartilage breaks down can be approximated by
levels of CTX-II.
"The blood tests revealed not only that risedronate stabilized
bone loss, but also that it was most likely slowing the
breakdown of cartilage, too" says Bingham.
Bingham emphasizes that X-rays failed to show any dramatic
visible changes in the structure of the joints with
risedronate compared to a placebo: however, the numbers of
patients exhibiting significant progression of the disease
were few in all treatment groups. A great challenge now is
identifying the risk factors for joint deterioration in
osteoarthritis, adds Bingham.
The investigators also did not see a significant reduction in
joint pain with risedronate compared with the placebo.
In the United States, where an estimated 25 million people
have osteoarthritis and 44 million have osteoporosis,
participants in the study group taking risedronate experienced
a noticeable drop in their CTX-II levels: 17.9 percent. The
Europeans fared even better, with a
19.6 percent decrease. Patients taking the drug at normal
levels and at higher than usual doses given for comparison
experienced similar slowdowns in cartilage decline, without
significant adverse side effects.
Those in the placebo group, however, experienced increases in
CTX-II levels (26.3 percent for the Americans and 10.1 percent
for the Europeans), suggesting that their cartilage was
deteriorating faster than that in those taking the drug.
"We are not recommending that everyone with arthritis run out
and get a prescription for these kinds of drugs, nor are we
suggesting at this time that doctors use risedronate as an
arthritis treatment," cautions Bingham. "But what we can say
now is that drugs affecting bone turnover need to be further
evaluated for their potential effects as arthritis therapies."
The blood test changes seen in the study would suggest that
people already taking bone strengthening drugs may be
simultaneously helping their joints, concludes Bingham.
NOTE: Dr. Bingham has received consulting fees from Proctor &
Gamble Pharmaceuticals, the makers of Actonel, the brand
name for risedronate. Additionally, several other
members of his research team have received consulting
fees from other pharmaceutical companies.
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=A9 2006 Newswise. All Rights Reserved.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
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