ironjustic
Mon, Nov-20-06, 17:16
These 11 cases ALL showed increased .. iron stores /
hyperferritinemia . AND .. again .. 'coincidentally' ..
hypertransaminasemia WHICH .. again
.=2E coincidentally .. is the ONLY marker which is DIAGNOSTIC
of the **lowering** of **iron** .. in hepatitis ..
It falls as iron load falls in hepatitis patients treated for
iron .. load.
So the bottom line here is .. 'they' .. say Still's / juvenile
rheumatoid arthritis patients are .. iron 'deficient' .. when
in FACT hypertansaminasemia .. is THE .. marker which ..
DIAGNOSES .. iron **excess** in hepatitis .. .=2E Throw in the
fact .. Still's patients get .. RELIEF .. by .. using
chloroquine / sulfasalazine / aspirin / tetracycline iron
binding substances .. would give .. quite a bit of ..
**evidence** .. that **iron** is NOT .. 'deficient' .. but is
ACTIVELY .. **involved** .. IN .. the disease .. COURSE ..
And the FACT one patient DIED .. due TO .. hepatitis MEANS the
'marker' of Hypertransaminasemia .. {Hypertransaminasemia
DIAGNOSTIC of INCREASED iron in hepatitis] .. gives credence
TO .. **excess** as opposed to .. iron 'deficiency'.
[Adult Still's disease: study of a series of 11 cases] Ben
Taarit C, Turki S, Ben Ma=EFz H J Mal Vasc. 2002 Feb ;
27(1): 31-5
Adult Still's disease is a systemic disease of unknown
etiology. We report a retrospective study of 11 cases (9
females and 2 males) of adult Still's disease collected during
25 years. The mean age was 36 years. Fever, arthritis and skin
rash was constant. Adenopathies and splenomegaly were observed
in 2 patients. The laboratory findings was characterized by a
constant inflammatory syndrome and leucocytosis.
Hypertransaminasemia and hyperferritinemia were observed
respectively in 7 cases and 3 cases. Corticosteroids were
prescribed in all patients. Methotrexate was administered in 3
patients. Outcome was favorable in 10 cases, death incurred in
one patient, secondary to acute hepatitis.
--------------------------------------------------------------
--------------=
--------------------------------
EXPERIMENTAL BIOLOGY UPDATE: Arthritic kids' iron supplements
may hasten joint deterioration
By Diana Swift
WWASHINGTON, D.C. - The iron supplements that many arthritic
children take to combat concomitant anemia may be hastening
the deterioration of their joints, Houston researchers say.
Led by biologist Roman Shypailo of the Children's Nutrition
Research Centre at Baylor College of Medicine, a Texas team
looked at eight children being
treated for juvenile rheumatoid arthritis. The patients, aged
five to 15 years,
received an intravenous radioactive tracer dose of iron (0.03
microsievert). Iron activity in affected joints was monitored
on a position/energy-sensitive gamma counter, while a second
machine monitored whole-body iron retention. Iron deposition
was measured two hours post-infusion and again at days seven,
14, 28 and 56.
Anemic "We found that iron excessively accumulates in
arthritic joints and probably contributes to the chronic
damage," said Shypailo. "That puts you between a rock and a
hard place because many of these arthritic kids are anemic and
need iron supplements, which may worsen the disease."
The study found a high level of agreement between the joint
data and the whole-body data, with a greater than 90%
retention rate of the infused iron both in joints and
systemically. Furthermore, six of eight patients showed
increased uptake at the affected joints: 165% over the first
30 days compared with initial uptake at two hours.
The next step, he says, is to see if there is excessive
deposition of dietary iron in arthritic joints.
--------------------------------------------------------------
-------------
<<snip>> beef and chicken muscle increased iron absorption
180% <<snip>>
Meat Protein Fractions Enhance Nonheme Iron Absorption in
Humans. Hurrell RF, Reddy MB, Juillerat M, Cook JD J Nutr.
2006 Nov ; 136(11): 2808-2812
The nature of the enhancing effect of muscle tissue on nonheme
iron absorption in humans is unclear but thought to be related
to muscle proteins. We conducted radioiron absorption studies
to compare iron absorption from proteins isolated from beef
and chicken muscle with that from freeze-dried beef and
chicken muscle and from egg albumin. All meals contained an
equivalent amount of protein as part of a semisynthetic liquid
formula. Freeze-dried beef and chicken muscle increased iron
absorption 180% (P < 0.001) and 100% (P < 0.001),
respectively, relative to egg albumin. When added to the meal
at an equivalent protein level (15 g), the isolated beef
protein and the isolated heme-free beef protein with 94 and
98% protein content, respectively, increased iron absorption
to the same extent as the native beef muscle. Similarly, when
added to the meal at an equivalent protein level (30 g),
isolated chicken muscle protein (94% protein) increased iron
absorption similarly to native chicken muscle. Iron absorption
from the meal containing the isolated heme-free chicken
protein, however, was 120% (P < 0.01) greater than from the
meal containing freeze-dried chicken muscle, indicating that a
nonprotein component of muscle tissue with iron-binding
potential may have been removed or concentrated by the protein
extraction and separation procedures. Our results support the
hypothesis that the enhancing effect of muscle tissue on iron
absorption is mainly protein related but indicate that other
factors may also play a role.
Abstract =B7 PubMed FullText =B7 SFX =B7 GS Clip Export
InterDB =B7 Terms Related =B7 Graph Cites =B7 Tag
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk
hyperferritinemia . AND .. again .. 'coincidentally' ..
hypertransaminasemia WHICH .. again
.=2E coincidentally .. is the ONLY marker which is DIAGNOSTIC
of the **lowering** of **iron** .. in hepatitis ..
It falls as iron load falls in hepatitis patients treated for
iron .. load.
So the bottom line here is .. 'they' .. say Still's / juvenile
rheumatoid arthritis patients are .. iron 'deficient' .. when
in FACT hypertansaminasemia .. is THE .. marker which ..
DIAGNOSES .. iron **excess** in hepatitis .. .=2E Throw in the
fact .. Still's patients get .. RELIEF .. by .. using
chloroquine / sulfasalazine / aspirin / tetracycline iron
binding substances .. would give .. quite a bit of ..
**evidence** .. that **iron** is NOT .. 'deficient' .. but is
ACTIVELY .. **involved** .. IN .. the disease .. COURSE ..
And the FACT one patient DIED .. due TO .. hepatitis MEANS the
'marker' of Hypertransaminasemia .. {Hypertransaminasemia
DIAGNOSTIC of INCREASED iron in hepatitis] .. gives credence
TO .. **excess** as opposed to .. iron 'deficiency'.
[Adult Still's disease: study of a series of 11 cases] Ben
Taarit C, Turki S, Ben Ma=EFz H J Mal Vasc. 2002 Feb ;
27(1): 31-5
Adult Still's disease is a systemic disease of unknown
etiology. We report a retrospective study of 11 cases (9
females and 2 males) of adult Still's disease collected during
25 years. The mean age was 36 years. Fever, arthritis and skin
rash was constant. Adenopathies and splenomegaly were observed
in 2 patients. The laboratory findings was characterized by a
constant inflammatory syndrome and leucocytosis.
Hypertransaminasemia and hyperferritinemia were observed
respectively in 7 cases and 3 cases. Corticosteroids were
prescribed in all patients. Methotrexate was administered in 3
patients. Outcome was favorable in 10 cases, death incurred in
one patient, secondary to acute hepatitis.
--------------------------------------------------------------
--------------=
--------------------------------
EXPERIMENTAL BIOLOGY UPDATE: Arthritic kids' iron supplements
may hasten joint deterioration
By Diana Swift
WWASHINGTON, D.C. - The iron supplements that many arthritic
children take to combat concomitant anemia may be hastening
the deterioration of their joints, Houston researchers say.
Led by biologist Roman Shypailo of the Children's Nutrition
Research Centre at Baylor College of Medicine, a Texas team
looked at eight children being
treated for juvenile rheumatoid arthritis. The patients, aged
five to 15 years,
received an intravenous radioactive tracer dose of iron (0.03
microsievert). Iron activity in affected joints was monitored
on a position/energy-sensitive gamma counter, while a second
machine monitored whole-body iron retention. Iron deposition
was measured two hours post-infusion and again at days seven,
14, 28 and 56.
Anemic "We found that iron excessively accumulates in
arthritic joints and probably contributes to the chronic
damage," said Shypailo. "That puts you between a rock and a
hard place because many of these arthritic kids are anemic and
need iron supplements, which may worsen the disease."
The study found a high level of agreement between the joint
data and the whole-body data, with a greater than 90%
retention rate of the infused iron both in joints and
systemically. Furthermore, six of eight patients showed
increased uptake at the affected joints: 165% over the first
30 days compared with initial uptake at two hours.
The next step, he says, is to see if there is excessive
deposition of dietary iron in arthritic joints.
--------------------------------------------------------------
-------------
<<snip>> beef and chicken muscle increased iron absorption
180% <<snip>>
Meat Protein Fractions Enhance Nonheme Iron Absorption in
Humans. Hurrell RF, Reddy MB, Juillerat M, Cook JD J Nutr.
2006 Nov ; 136(11): 2808-2812
The nature of the enhancing effect of muscle tissue on nonheme
iron absorption in humans is unclear but thought to be related
to muscle proteins. We conducted radioiron absorption studies
to compare iron absorption from proteins isolated from beef
and chicken muscle with that from freeze-dried beef and
chicken muscle and from egg albumin. All meals contained an
equivalent amount of protein as part of a semisynthetic liquid
formula. Freeze-dried beef and chicken muscle increased iron
absorption 180% (P < 0.001) and 100% (P < 0.001),
respectively, relative to egg albumin. When added to the meal
at an equivalent protein level (15 g), the isolated beef
protein and the isolated heme-free beef protein with 94 and
98% protein content, respectively, increased iron absorption
to the same extent as the native beef muscle. Similarly, when
added to the meal at an equivalent protein level (30 g),
isolated chicken muscle protein (94% protein) increased iron
absorption similarly to native chicken muscle. Iron absorption
from the meal containing the isolated heme-free chicken
protein, however, was 120% (P < 0.01) greater than from the
meal containing freeze-dried chicken muscle, indicating that a
nonprotein component of muscle tissue with iron-binding
potential may have been removed or concentrated by the protein
extraction and separation procedures. Our results support the
hypothesis that the enhancing effect of muscle tissue on iron
absorption is mainly protein related but indicate that other
factors may also play a role.
Abstract =B7 PubMed FullText =B7 SFX =B7 GS Clip Export
InterDB =B7 Terms Related =B7 Graph Cites =B7 Tag
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk