Ironjustic
Mon, Nov-20-06, 06:15
<<sniip>> antioxidants might be an effective therapeutic
approach to partially alleviate or prevent the symptoms of
schizophrenia <<snip>>
J Zhejiang Univ Sci B. 2006 Dec.;7(12):981-986. Links
Imbalanced free radicals and antioxidant defense systems in
schizophrenia: A comparative study.Li HC, Chen QZ, Ma Y, Zhou
JF. Department of Psychiatry, the Second Affiliated Hospital,
School of Medicine, Zhejiang University, Hangzhou 310009,
China; zrjsk@zju.edu.cn.
Objective: To examine changes of blood oxidative-antiovidative
level in schizophrenic patients and its relationship with
clinical symptoms. Methods: Forty-six Chinese patients met
DSM-IV (Diagnostic and Statistical Manual of Mental
Disorders-IV) criteria for schizophrenia and fifty age- and
sex-matched healthy controls were enrolled in the present
study. Baseline psychiatric symptom severity was assessed with
brief psychiatric rating scale, positive and negative syndrome
scale on the blood draw day. Fresh blood samples were
collected to measure levels of nitric oxide and lipid peroxide
in plasma as well as activities of superoxide dismutase,
catalase and glutathione peroxidase in red blood cells by
spectrophotometric assays simultaneously. Results: Comparison
of the biochemical parameters indicated that the level of
nitric oxide and lipid peroxide increased in patient group,
which represented a positive correlation with positive scale
scores; while the activities of three critical enzymes
decreased and showed a negative linear correlation.
Conclusion: This study showed that there are dysregulation of
free radical metabolism and poor activities of the antioxidant
defense systems in schizophrenic patients. Excess free
radicals formation may play a critical role in the etiology of
schizophrenia. Using antioxidants might be an effective
therapeutic approach to partially alleviate or prevent the
symptoms of schizophrenia.
PMID: 17111467 [PubMed - as supplied by publisher]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
approach to partially alleviate or prevent the symptoms of
schizophrenia <<snip>>
J Zhejiang Univ Sci B. 2006 Dec.;7(12):981-986. Links
Imbalanced free radicals and antioxidant defense systems in
schizophrenia: A comparative study.Li HC, Chen QZ, Ma Y, Zhou
JF. Department of Psychiatry, the Second Affiliated Hospital,
School of Medicine, Zhejiang University, Hangzhou 310009,
China; zrjsk@zju.edu.cn.
Objective: To examine changes of blood oxidative-antiovidative
level in schizophrenic patients and its relationship with
clinical symptoms. Methods: Forty-six Chinese patients met
DSM-IV (Diagnostic and Statistical Manual of Mental
Disorders-IV) criteria for schizophrenia and fifty age- and
sex-matched healthy controls were enrolled in the present
study. Baseline psychiatric symptom severity was assessed with
brief psychiatric rating scale, positive and negative syndrome
scale on the blood draw day. Fresh blood samples were
collected to measure levels of nitric oxide and lipid peroxide
in plasma as well as activities of superoxide dismutase,
catalase and glutathione peroxidase in red blood cells by
spectrophotometric assays simultaneously. Results: Comparison
of the biochemical parameters indicated that the level of
nitric oxide and lipid peroxide increased in patient group,
which represented a positive correlation with positive scale
scores; while the activities of three critical enzymes
decreased and showed a negative linear correlation.
Conclusion: This study showed that there are dysregulation of
free radical metabolism and poor activities of the antioxidant
defense systems in schizophrenic patients. Excess free
radicals formation may play a critical role in the etiology of
schizophrenia. Using antioxidants might be an effective
therapeutic approach to partially alleviate or prevent the
symptoms of schizophrenia.
PMID: 17111467 [PubMed - as supplied by publisher]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk