Ironjustic
Fri, Sep-29-06, 17:15
<<snip>> Oxidative stress may contribute to the pathogenesis
of chronic pancreatitis <<snip>>
Assessment of oxidative stress in chronic pancreatitis
patients. Verlaan M, Roelofs HM, van-Schaik A, Wanten GJ,
Jansen JB, Peters WH, Drenth JP World J Gastroenterol. 2006
Sep 21; 12(35): 5705-10
AIM: To assess the levels of antioxidant capacity and
oxidative damage in blood of chronic pancreatitis (CP)
patients in comparison with those in healthy control
subjects, by using several different analytical techniques.
METHODS: Thirty-five CP patients and 35 healthy control
subjects were investigated prospectively with respect to
plasma levels of thiols, ferric reducing ability of plasma
(FRAP, i.e. antioxidant capacity), levels of protein
carbonyls and thiobarbituric acid reactive substances
(TBARS). Additionally, we evaluated the production of
reactive oxygen species (ROS) in whole blood. RESULTS: The
antioxidative thiols including cysteine, cysteinylglycine
and glutathione were significantly lower in CP patients. In
addition, the non-enzymatic antioxidant capacity was
significantly lower in CP patients, which correlated with
the amount of oxidative protein (protein carbonyls) and the
extent of lipid damage (TBARS), both were significantly
higher in CP patients. The ROS production in whole blood
after stimulation with phorbol 12-myritate 13-acetaat,
demonstrated a strong tendency to produce more ROS in CP
patients. CONCLUSION: Oxidative stress may contribute to the
pathogenesis of chronic pancreatitis by decreasing
antioxidant capacity and increasing oxidative damage in CP
patients may be a rationale for intervention with
antioxidant therapy.
Abstract =B7 PubMed FullText =B7 SFX =B7 GS Clip Export
InterDB =B7 Terms Related =B7 Graph Cites =B7 Tag
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk
of chronic pancreatitis <<snip>>
Assessment of oxidative stress in chronic pancreatitis
patients. Verlaan M, Roelofs HM, van-Schaik A, Wanten GJ,
Jansen JB, Peters WH, Drenth JP World J Gastroenterol. 2006
Sep 21; 12(35): 5705-10
AIM: To assess the levels of antioxidant capacity and
oxidative damage in blood of chronic pancreatitis (CP)
patients in comparison with those in healthy control
subjects, by using several different analytical techniques.
METHODS: Thirty-five CP patients and 35 healthy control
subjects were investigated prospectively with respect to
plasma levels of thiols, ferric reducing ability of plasma
(FRAP, i.e. antioxidant capacity), levels of protein
carbonyls and thiobarbituric acid reactive substances
(TBARS). Additionally, we evaluated the production of
reactive oxygen species (ROS) in whole blood. RESULTS: The
antioxidative thiols including cysteine, cysteinylglycine
and glutathione were significantly lower in CP patients. In
addition, the non-enzymatic antioxidant capacity was
significantly lower in CP patients, which correlated with
the amount of oxidative protein (protein carbonyls) and the
extent of lipid damage (TBARS), both were significantly
higher in CP patients. The ROS production in whole blood
after stimulation with phorbol 12-myritate 13-acetaat,
demonstrated a strong tendency to produce more ROS in CP
patients. CONCLUSION: Oxidative stress may contribute to the
pathogenesis of chronic pancreatitis by decreasing
antioxidant capacity and increasing oxidative damage in CP
patients may be a rationale for intervention with
antioxidant therapy.
Abstract =B7 PubMed FullText =B7 SFX =B7 GS Clip Export
InterDB =B7 Terms Related =B7 Graph Cites =B7 Tag
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk