Ironjustic
Fri, Sep-29-06, 06:15
This article appears .. older .. but it only just appeared in
Medline ..
<<snip>. Patients with DM2 had higher transferrin saturation
compared to the general population. The DM2 patients had
higher ferritin levels compared to controls. In conclusion,
DM2 patients have increased iron load <<snip>>
1: Hormones (Athens). 2003 Jan-Mar;2(1):55-60. Links The role
of Hemochromatosis C282Y and H63D mutations in the
development of type 2 diabetes mellitus in Greece.Habeos
IG, Psyrogiannis A, Kyriazopoulou V, Psilopanagiotou A,
Papavassiliou AG, Vagenakis AG. Division of Endocrinology
and Diabetes, Department of Medicine, University of Patras
Medical School, Patras, Greece.
Several authors have suggested a positive association between
diabetes type 2 (DM2) and the C282Y and H63D mutations of the
hereditary hemochromatosis gene but others have disputed it.
There are also papers reporting an increased iron load in
diabetes type 2 and a possible association with the
pathogenesis of the disease. We therefore performed a study in
100 type 2 diabetics and 100 age and sex matched controls to
assess the possibility that C282Y and H63D mutations
constitute a risk factor for DM2 in Greece. We also evaluated
the iron load in 500 diabetes type 2 patients and 423 age and
sex matched controls. We did not find any differences in the
allele frequencies of the above mutations between patients
with diabetes type 2 and controls. The allele frequencies were
estimated to be 0.0075 for the C282Y and .115 for the H63D
mutation. Subjects with even one mutation (C282Y or
H63D) had higher transferrin saturation compared to those with
no such mutations. This seems to apply to both diabetics
(49+/- 8,6 vs 44,5+/- 5,4, p<0,01) and controls (49,3+/-
7,3 vs 42,6+/- 3,3 p<0,01). Patients with DM2 had higher
transferrin saturation compared to the general
population. These differences were found among men
(n=250, mean+/- SD 31,8+11 vs n=73, mean+/- SD 29,5+8,
p=0,05) as well as among women (n=250, mean+/- SD
28.5+10 vs n=350, mean+/- SD 25.5+9.6, p=0.001). The DM2
patients had higher ferritin levels compared to
controls. In conclusion, DM2 patients have increased
iron load. The C282Y and H63D mutations contribute to
increased iron load in both DM2 and controls. There was
no difference in the frequency of C282Y and H63D alleles
between DM2 and controls in the Hellenic population.
PMID: 17003003 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Medline ..
<<snip>. Patients with DM2 had higher transferrin saturation
compared to the general population. The DM2 patients had
higher ferritin levels compared to controls. In conclusion,
DM2 patients have increased iron load <<snip>>
1: Hormones (Athens). 2003 Jan-Mar;2(1):55-60. Links The role
of Hemochromatosis C282Y and H63D mutations in the
development of type 2 diabetes mellitus in Greece.Habeos
IG, Psyrogiannis A, Kyriazopoulou V, Psilopanagiotou A,
Papavassiliou AG, Vagenakis AG. Division of Endocrinology
and Diabetes, Department of Medicine, University of Patras
Medical School, Patras, Greece.
Several authors have suggested a positive association between
diabetes type 2 (DM2) and the C282Y and H63D mutations of the
hereditary hemochromatosis gene but others have disputed it.
There are also papers reporting an increased iron load in
diabetes type 2 and a possible association with the
pathogenesis of the disease. We therefore performed a study in
100 type 2 diabetics and 100 age and sex matched controls to
assess the possibility that C282Y and H63D mutations
constitute a risk factor for DM2 in Greece. We also evaluated
the iron load in 500 diabetes type 2 patients and 423 age and
sex matched controls. We did not find any differences in the
allele frequencies of the above mutations between patients
with diabetes type 2 and controls. The allele frequencies were
estimated to be 0.0075 for the C282Y and .115 for the H63D
mutation. Subjects with even one mutation (C282Y or
H63D) had higher transferrin saturation compared to those with
no such mutations. This seems to apply to both diabetics
(49+/- 8,6 vs 44,5+/- 5,4, p<0,01) and controls (49,3+/-
7,3 vs 42,6+/- 3,3 p<0,01). Patients with DM2 had higher
transferrin saturation compared to the general
population. These differences were found among men
(n=250, mean+/- SD 31,8+11 vs n=73, mean+/- SD 29,5+8,
p=0,05) as well as among women (n=250, mean+/- SD
28.5+10 vs n=350, mean+/- SD 25.5+9.6, p=0.001). The DM2
patients had higher ferritin levels compared to
controls. In conclusion, DM2 patients have increased
iron load. The C282Y and H63D mutations contribute to
increased iron load in both DM2 and controls. There was
no difference in the frequency of C282Y and H63D alleles
between DM2 and controls in the Hellenic population.
PMID: 17003003 [PubMed - in process]
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk