Ironjustic
Thu, Sep-28-06, 17:15
<<snip>> ferritin concentration is related to insulin
resistance <<snip>>
Relative iron "overload" in offspring of patients with type 2
diabetes mellitus: a new component in the conundrum of insulin
resistance syndrome?
Psyrogiannis A, Kyriazopoulou V, Symeonidis A, Leotsinidis M,
Vagenakis AG Hormones (Athens). 2003 Jul-Sep ; 2(3): 161-8
There are a few reports suggesting that subtle disturbances of
iron metabolism are frequently found in patients with type 2
diabetes (DM2), but it is not known if these disturbances
precede or accompany the diabetic state. We investigated the
serum iron indices in 41 offspring of DM2 parents (group I)
with normal glucose tolerance, and in 49 offspring whose
parents had no history of DM2 and were matched for sex, age,
body mass index (BMI), waist to hip ratio (WHR) and blood
pressure (group II). Serum iron, ferritin, total iron binding
capacity (TIBC), transferrin saturation, serum triglycerides,
cholesterol, Apo-B, high density lipoprotein (HDL) and glucose
and insulin values during an oral glucose tolerance test were
measured. Insulin resistance was assessed using the
homeostasis model assessment (HOMA - Insuline resistence
index-IRI). In comparison to controls (group II), the
offspring of DM2 subjects (group I) had higher fasting serum
triglycerides (mean +/- SD 2=2E25+/-2.08 vs. 1.6+/-0.8 mmol/L,
p<0,05), lower HDL cholesterol (0.96 +/- 0.2 vs. 1.1 +/- 0.2
mmol/L, p<0.001), higher total cholesterol (5.5 +/- 1.1 vs.
5.1 +/- 0.8 mmol/L, p < 0.05), higher apo-B-lipoprotein
(133.2+/-34.3 vs. 125.5+/-30.5 mg/dl, p<0.05), higher LDL-C
(3.7 +/- =2E8 vs. 3.2 +/- 0.6 mmol/L), higher gamma-GT
(28+/-10 vs. 17+/-5.6
iu/L, p<0.01) higher insulin in the Area Under the Curve
(204.7+/-140.8 v=2E 153.1 +/- 63.0 microU/ml, p<0.05) and
higher HOMA-IRI (2.84+/-1.39
iv. 1.67+/-0.77, p<0.001), higher serum ferritin
concentrations
(98.3+/-57.7 vs. 62.0+/-41.1 ng/ml, p<0.01), higher serum
iron concentration (20.2+/-6.0 micromol/L vs. 14.5+/-4.3,
p<0.001) and higher transferrin saturation index
(31.3+/-8.4 vs. 22.6+/-7.3, p<0.0001). By single linear
analysis in the offspring of DM2 parents, there was a
positive correlation of IRI with transferrin saturation
(r=3D0.400, p<0.01), fibrinogen (r=3D0.377, p=3D0.025)
and ferritin concentration (r=3D0.344, p=3D0.041), and a
negative correlation with TIBC (r=3D-0.477, p < 0.0001),
while stepwise multiple regression analysis, IRI showed a
positive correlation with fibrinogen (b=3D0.64,
t=3D3.746, p<0.001), triglycerides (b=3D0.37, t=3D2.619,
p<0.01) and ferritin (b=3D0.2= , t=3D1.827, p=3D0.05). No
correlation of IRI, with any of the above parameters was
seen in the offspring of normal parents. By logistic
regression analysis the parameters characterizing the
offspring of parents with DM2 were IRI (OR 14.9 CI
2.4-91.0) serum iron (OR 44.2 CI 6=2E9-281), TIBC (OR 6.1
CI 1.01-37.0 and gamma-GT (OR 29.6 CI 5.0-174). In
conclusion, the data indicate that the iron load, is
significantly increased in offspring of DM2 subjects with
unaffected glucose tolerance. Furthermore, ferritin
concentration is related to insulin resistance. Hence,
the relative iron "overload" in offspring of type 2
diabetics is present along with insulin resistance and
might worsen the hepatic insulin insensitivity already
present in these patients.
Abstract =B7 PubMed FullText =B7 SFX =B7 GS Clip Export
InterDB =B7 Terms Related =B7 Graph Cites =B7 Tag
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk
resistance <<snip>>
Relative iron "overload" in offspring of patients with type 2
diabetes mellitus: a new component in the conundrum of insulin
resistance syndrome?
Psyrogiannis A, Kyriazopoulou V, Symeonidis A, Leotsinidis M,
Vagenakis AG Hormones (Athens). 2003 Jul-Sep ; 2(3): 161-8
There are a few reports suggesting that subtle disturbances of
iron metabolism are frequently found in patients with type 2
diabetes (DM2), but it is not known if these disturbances
precede or accompany the diabetic state. We investigated the
serum iron indices in 41 offspring of DM2 parents (group I)
with normal glucose tolerance, and in 49 offspring whose
parents had no history of DM2 and were matched for sex, age,
body mass index (BMI), waist to hip ratio (WHR) and blood
pressure (group II). Serum iron, ferritin, total iron binding
capacity (TIBC), transferrin saturation, serum triglycerides,
cholesterol, Apo-B, high density lipoprotein (HDL) and glucose
and insulin values during an oral glucose tolerance test were
measured. Insulin resistance was assessed using the
homeostasis model assessment (HOMA - Insuline resistence
index-IRI). In comparison to controls (group II), the
offspring of DM2 subjects (group I) had higher fasting serum
triglycerides (mean +/- SD 2=2E25+/-2.08 vs. 1.6+/-0.8 mmol/L,
p<0,05), lower HDL cholesterol (0.96 +/- 0.2 vs. 1.1 +/- 0.2
mmol/L, p<0.001), higher total cholesterol (5.5 +/- 1.1 vs.
5.1 +/- 0.8 mmol/L, p < 0.05), higher apo-B-lipoprotein
(133.2+/-34.3 vs. 125.5+/-30.5 mg/dl, p<0.05), higher LDL-C
(3.7 +/- =2E8 vs. 3.2 +/- 0.6 mmol/L), higher gamma-GT
(28+/-10 vs. 17+/-5.6
iu/L, p<0.01) higher insulin in the Area Under the Curve
(204.7+/-140.8 v=2E 153.1 +/- 63.0 microU/ml, p<0.05) and
higher HOMA-IRI (2.84+/-1.39
iv. 1.67+/-0.77, p<0.001), higher serum ferritin
concentrations
(98.3+/-57.7 vs. 62.0+/-41.1 ng/ml, p<0.01), higher serum
iron concentration (20.2+/-6.0 micromol/L vs. 14.5+/-4.3,
p<0.001) and higher transferrin saturation index
(31.3+/-8.4 vs. 22.6+/-7.3, p<0.0001). By single linear
analysis in the offspring of DM2 parents, there was a
positive correlation of IRI with transferrin saturation
(r=3D0.400, p<0.01), fibrinogen (r=3D0.377, p=3D0.025)
and ferritin concentration (r=3D0.344, p=3D0.041), and a
negative correlation with TIBC (r=3D-0.477, p < 0.0001),
while stepwise multiple regression analysis, IRI showed a
positive correlation with fibrinogen (b=3D0.64,
t=3D3.746, p<0.001), triglycerides (b=3D0.37, t=3D2.619,
p<0.01) and ferritin (b=3D0.2= , t=3D1.827, p=3D0.05). No
correlation of IRI, with any of the above parameters was
seen in the offspring of normal parents. By logistic
regression analysis the parameters characterizing the
offspring of parents with DM2 were IRI (OR 14.9 CI
2.4-91.0) serum iron (OR 44.2 CI 6=2E9-281), TIBC (OR 6.1
CI 1.01-37.0 and gamma-GT (OR 29.6 CI 5.0-174). In
conclusion, the data indicate that the iron load, is
significantly increased in offspring of DM2 subjects with
unaffected glucose tolerance. Furthermore, ferritin
concentration is related to insulin resistance. Hence,
the relative iron "overload" in offspring of type 2
diabetics is present along with insulin resistance and
might worsen the hepatic insulin insensitivity already
present in these patients.
Abstract =B7 PubMed FullText =B7 SFX =B7 GS Clip Export
InterDB =B7 Terms Related =B7 Graph Cites =B7 Tag
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk