Diet / skin cancer

[Ironjustic]

<<snip>> Supplementary omega-3 FA significantly reduces the
level of pro-inflammatory and immunosuppressive PGE(2) levels
in Ultraviolet B-irradiated human skin. <<snip>>

Cancer Detect Prev. 2006;30(3):224-32. Epub 2006 Jul 26. Links
The potential of omega-3 fatty acids in the prevention of
non-melanoma skin cancer.Black HS, Rhodes LE. Department of
Dermatology, Baylor College of Medicine, Houston, TX 77030,
USA. hblack@bcm.tmc.edu

In toto, there is strong circumstantial evidence from both
experimental and clinical studies to support a role for
omega-3 FA in the prevention of non-melanoma skin cancer
(NMSC). In experimental animal studies there is direct
evidence that dietary omega-3 FA inhibits ultraviolet
radiation (UVR) carcinogenic expression, with regard to both
increased tumor latent period and reduced tumor multiplicity.
Equivalent levels of omega-6 FA increase UVR carcinogenic
expression. Dietary omega-3 FA dramatically reduces the plasma
and cutaneous pro-inflammatory and immunosuppressive PGE(2)
levels in mice. Dietary omega-6 FA increases prostaglandin E
synthase type 2 (PGE(2)) level. Dietary omega-3 FA
significantly reduces the inflammatory response and sustains,
or enhances, the delayed type hypersensitivity immune response
in mice when compared to an equivalent dietary level of
omega-6 FA. Supplementary omega-3 FA significantly increases
the UVR-mediated erythema threshold in humans. Supplementary
omega-3 FA significantly reduces the level of pro-inflammatory
and immunosuppressive PGE(2) levels in Ultraviolet
B-irradiated human skin.

PMID: 16872755 [PubMed - in process]

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