Joint complaints and blistering skin lesions on sun-exposed skin

[Ironjustic]

Neth J Med. 2006 Sep;64(8):307-9. Links Sporadic porphyria
cutanea tarda due to haemochromatosis.de Geus HR, Dees A.
Department of Intensive Care, Erasmus Medical Centre,
Rotterdam, the Netherlands.

Haemochromatosis is a hereditary iron-overload syndrome caused
by increased intestinal iron absorption and characterised by
accumulation of potentially toxic iron in the tissues.
Sometimes this disease presents as a cutanea porphyria. We
describe a patient with joint complaints and blistering skin
lesions on sun-exposed skin. After identifying the porphyria
cutanea tarda by urine analysis we found that the serum
activity of uroporphyrinogen decarboxylase (UROD) was normal,
meaning a partial inactivation of UROD in liver tissue due to
external factors. Further investigation showed the homozygous
Cys282Tyr missense mutation and high levels of serum ferritin.
It is important to recognise the symptoms of iron overloading
at an early stage because hereditary haemochromatosis needs to
be treated immediately. We therefore advocate routine sampling
of ferritin levels in patients with unexplained joint
complaints.

PMID: 16990695 [PubMed - in process]

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[David]

I am interested in this report as I have been looking for
something for my wife. she had chemo 6 years ago and 3 years
ago, developed extreme sensivity to the sun. No known cause or
solution at this stage. I am sure it is a toxin, but blood
tests show normal blood levels of most common metals etc. Any
ideas?? thanks

ironjustice@aol.com wrote:
> Neth J Med. 2006 Sep;64(8):307-9. Links Sporadic porphyria
> cutanea tarda due to haemochromatosis.de Geus HR, Dees A.
> Department of Intensive Care, Erasmus Medical Centre,
> Rotterdam, the Netherlands.
>
> Haemochromatosis is a hereditary iron-overload syndrome
> caused by increased intestinal iron absorption and
> characterised by accumulation of potentially toxic iron in
> the tissues. Sometimes this disease presents as a cutanea
> porphyria. We describe a patient with joint complaints and
> blistering skin lesions on sun-exposed skin. After
> identifying the porphyria cutanea tarda by urine analysis we
> found that the serum activity of uroporphyrinogen
> decarboxylase (UROD) was normal, meaning a partial
> inactivation of UROD in liver tissue due to external
> factors. Further investigation showed the homozygous
> Cys282Tyr missense mutation and high levels of serum
> ferritin. It is important to recognise the symptoms of iron
> overloading at an early stage because hereditary
> haemochromatosis needs to be treated immediately. We
> therefore advocate routine sampling of ferritin levels in
> patients with unexplained joint complaints.
>
> PMID: 16990695 [PubMed - in process]
>
>
> Who loves ya. Tom
>
>
> Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore! http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

[Ironjustic]

david wrote:
> I am interested in this report as I have been looking for
> something for my wife. she had chemo 6 years ago and 3 years
> ago, developed extreme sensivity to the sun. No known cause
> or solution at this stage. I am sure it is a toxin, but
> blood tests show normal blood levels of most common metals
> etc. Any ideas?? thanks
>
> ironjustice@aol.com wrote:
> > Neth J Med. 2006 Sep;64(8):307-9. Links Sporadic porphyria
> > cutanea tarda due to haemochromatosis.de Geus HR, Dees A.
> > Department of Intensive Care, Erasmus Medical Centre,
> > Rotterdam, the Netherlands.
> >
> > Haemochromatosis is a hereditary iron-overload syndrome
> > caused by increased intestinal iron absorption and
> > characterised by accumulation of potentially toxic iron in
> > the tissues. Sometimes this disease presents as a cutanea
> > porphyria. We describe a patient with joint complaints and
> > blistering skin lesions on sun-exposed skin. After
> > identifying the porphyria cutanea tarda by urine analysis
> > we found that the serum activity of uroporphyrinogen
> > decarboxylase (UROD) was normal, meaning a partial
> > inactivation of UROD in liver tissue due to external
> > factors. Further investigation showed the homozygous
> > Cys282Tyr missense mutation and high levels of serum
> > ferritin. It is important to recognise the symptoms of
> > iron overloading at an early stage because hereditary
> > haemochromatosis needs to be treated immediately. We
> > therefore advocate routine sampling of ferritin levels in
> > patients with unexplained joint complaints.
> >
> > PMID: 16990695 [PubMed - in process]
> >
> >
> > Who loves ya. Tom
> >
> >
> > Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
> >
> >
> > Man Is A Herbivore! http://tinyurl.com/a3cc3
> >
> >
> > DEAD PEOPLE WALKING http://tinyurl.com/zk9fk

>>developed extreme sensivity to the sun.<<

It depends I suppose on what kind of .. "sensitivity to the
sun" .. you are talking about .. but not .. really ..

Radiation leads to a decrease of antioxidants in the body ..
Radiation is just oxidation ..

Soooo .. I would increase my intake of antioxidant rich foods
.. and decrease my intake of foods which .. decrease ..
antioxidants.

Uveitis / sensitivity to the sun in your .. eyes .. has been
shown to be linked to a decrease in antioxidants .. ie:
"oxidant thrust " .. http://tinyurl.com/qh8aq

Same with sensitivity to the sun .. hence the addition of
antioxidants to topical preparations for the skin to prevent
sunburn ..

http://tinyurl.com/s2gx9

>>Any ideas??<<

It seems the "phosphate groups" mentioned in this study are
simply the ingredients found in vegetable oil / lecithin and
therefore .. in theory .. vegetable oil rich in phosphate
groups applied liberally to the skin should lead to decreased
oxidation and increased antioxidants IN the body / your wife.

http://tinyurl.com/hr6kh

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk