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Neurobiology of Aging Volume 27, Issue 7 , July 2006, Pages
1035-1044 doi:10.1016/j.neurobiolaging.2005.05.003 Copyright
=A9 2005 Published by Elsevier Inc. The effects of
antioxidants in the senescent auditory cortex
C=2E de Riveraa, B. Shukitt-Haleb, J.A. Josephb and J.R.
Mendelsona, ,
aDepartment of Speech-Language Pathology, University of
Toronto, Toronto, Ont., Canada M5G 1V7 bUnited States
Department of Agriculture Human Nutrition Research Center on
Aging at Tufts, Boston, MA 02111, USA
Received 10 January 2005; revised 19 April 2005; accepted 2
May 2005. Available online 13 June 2005.
Abstract We investigated whether a 2-month dietary
supplementation of antioxidants, in the form of blueberry
phytochemicals, could reverse or retard the age-related
decline in temporal processing speed observed in the aged rat.
To this end, extracellular single unit responses to frequency
modulated (FM) sweeps were recorded in the primary auditory
cortex (AI) of aged rats that had been placed on either a
blueberry-supplemented or control diet 2 months prior to the
physiological recordings. Results showed that most cells
recorded from the blueberry-fed rats responded most vigorously
to fast FM sweeps, similar to that observed in young rats. In
contrast, the majority of cells recorded from the control rats
showed a preference for slow FM sweep rates. These results
suggest that age-related changes in temporal processing speed
in A1 may be reversed by dietary supplementation of blueberry
phytochemicals.
Keywords: Aging; Auditory cortex; Antioxidants; Temporal
processing speed; Frequency modulated sweeps; Blueberries
Corresponding author. Present address: Toronto Rehabilitation
Institute, University Centre, 550 University Ave., Toronto,
Ont., Canada M5G 2A2. Tel.: +1 416 597 3422x3852.
Neurobiology of Aging Volume 27, Issue 7 , July 2006,
Pages 1035-1044
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk
1035-1044 doi:10.1016/j.neurobiolaging.2005.05.003 Copyright
=A9 2005 Published by Elsevier Inc. The effects of
antioxidants in the senescent auditory cortex
C=2E de Riveraa, B. Shukitt-Haleb, J.A. Josephb and J.R.
Mendelsona, ,
aDepartment of Speech-Language Pathology, University of
Toronto, Toronto, Ont., Canada M5G 1V7 bUnited States
Department of Agriculture Human Nutrition Research Center on
Aging at Tufts, Boston, MA 02111, USA
Received 10 January 2005; revised 19 April 2005; accepted 2
May 2005. Available online 13 June 2005.
Abstract We investigated whether a 2-month dietary
supplementation of antioxidants, in the form of blueberry
phytochemicals, could reverse or retard the age-related
decline in temporal processing speed observed in the aged rat.
To this end, extracellular single unit responses to frequency
modulated (FM) sweeps were recorded in the primary auditory
cortex (AI) of aged rats that had been placed on either a
blueberry-supplemented or control diet 2 months prior to the
physiological recordings. Results showed that most cells
recorded from the blueberry-fed rats responded most vigorously
to fast FM sweeps, similar to that observed in young rats. In
contrast, the majority of cells recorded from the control rats
showed a preference for slow FM sweep rates. These results
suggest that age-related changes in temporal processing speed
in A1 may be reversed by dietary supplementation of blueberry
phytochemicals.
Keywords: Aging; Auditory cortex; Antioxidants; Temporal
processing speed; Frequency modulated sweeps; Blueberries
Corresponding author. Present address: Toronto Rehabilitation
Institute, University Centre, 550 University Ave., Toronto,
Ont., Canada M5G 2A2. Tel.: +1 416 597 3422x3852.
Neurobiology of Aging Volume 27, Issue 7 , July 2006,
Pages 1035-1044
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk