Cyanotic nephropathy / erythrocytosis

[Ironjustic]

<<snip>> hyperviscosity by polycythemia may be responsible for
the development of CN <<snip>>

Mechanisms of development and progression of cyanotic
nephropathy. Inatomi J, Matsuoka K, Fujimaru R, Nakagawa A,
Iijima K Pediatr Nephrol. 2006 Aug 11;

Cyanotic nephropathy (CN) is often accompanied by congenital
cyanotic heart diseases (CCHD). The purpose of this study was
to clarify the risk factors and the mechanisms of involved in
the development and progression of CN. Thirty patients with
CCHD were examined. We analyzed the risk factors for the
development of CN on the basis of the clinical and laboratory
findings. We also examined ten renal biopsy specimens obtained
from patients with CN. Patients with CN showed significantly
higher hematocrit levels than those without CN (P=0.025),
although there was no difference between the two groups in
terms of oxygen saturation. The renal plasma flow (RPF) in
patients both with and without CN was low. However, the
filtration fraction (FF) was significantly lower in patients
with CN than in those without CN (P=0.001). The glomeruli of
biopsy specimens with significant proteinuria (n=7) were
larger than those of biopsy specimens without significant
proteinuria, and there were more capillaries per glomerulus in
the former than in the latter (n=3) and the control specimens
(n=6) (glomerular size: P<0.01; number of glomerular
capillaries: P<0.01). In conclusion, hyperviscosity by
polycythemia may be responsible for the development of CN.
This pathological condition may induce an angiogenic increase
in the glomerular capillary beds, in turn leading to
glomerulomegaly. In addition, the failure of a compensatory
mechanism to respond to reduced RPF by hyperfiltration may be
accompanied by the development and progression of CN.

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore! http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING http://tinyurl.com/zk9fk