Ironjustic
Sun, Aug-13-06, 17:16
http://tinyurl.com/mtsvl
Iron studied as a control for Pseudomonas aeruginosa biofilm
formation.
According to a study from the United States, "Iron serves as a
signal in Pseudomonas aeruginosa biofilm development. We
examined the influence of mutations in known and putative iron
acquisition-signaling genes on biofilm morphology.".
"In iron-sufficient medium, mutants that cannot obtain iron
through the high-affinity pyoverdine iron acquisition system
form thin biofilms similar to those formed by the parent under
low iron conditions. If an iron source for a different iron
acquisition system is provided to a pyoverdine mutant, normal
biofilm development occurs. This enabled us to identify iron
uptake gene clusters that likely serve in transport of ferric
citrate and ferrioxamine," wrote E. Banin and colleagues,
University of Washington.
"We suggest," proposed researchers, "that the functional iron
signal for P. aeruginosa biofilm development is active
transport of chelated iron or the level of internal iron. If
the signal is internal iron levels, then a factor likely to be
involved in iron signaling is the cytoplasmic ferric uptake
regulator protein, Fur, which controls expression of
iron-responsive genes.
"In support of a Fur involvement, we found that with low iron
a Fur mutant was able to organize into more mature biofilms
than was the parent. The two known Fur-controlled small
regulatory RNAs (PrrF1 and
F2) do not appear to mediate iron control of biofilm
development.".
"This information," concluded investigators, "establishes a
mechanistic basis for iron control of P. aeruginosa biofilm
formation.".
Banin and colleagues published the results of their research
in Proceedings of the National Academy of Sciences of the
United States of America (Iron and Pseudomonas aeruginosa
biofilm formation. Proc Natl Acad Sci USA,
2005;102(31):11076-11081).
For additional information, contact E.P. Greenberg, University
of Washington, School of Medicine, Dept. Microbiology,
Seattle, WA 98195, USA.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Iron studied as a control for Pseudomonas aeruginosa biofilm
formation.
According to a study from the United States, "Iron serves as a
signal in Pseudomonas aeruginosa biofilm development. We
examined the influence of mutations in known and putative iron
acquisition-signaling genes on biofilm morphology.".
"In iron-sufficient medium, mutants that cannot obtain iron
through the high-affinity pyoverdine iron acquisition system
form thin biofilms similar to those formed by the parent under
low iron conditions. If an iron source for a different iron
acquisition system is provided to a pyoverdine mutant, normal
biofilm development occurs. This enabled us to identify iron
uptake gene clusters that likely serve in transport of ferric
citrate and ferrioxamine," wrote E. Banin and colleagues,
University of Washington.
"We suggest," proposed researchers, "that the functional iron
signal for P. aeruginosa biofilm development is active
transport of chelated iron or the level of internal iron. If
the signal is internal iron levels, then a factor likely to be
involved in iron signaling is the cytoplasmic ferric uptake
regulator protein, Fur, which controls expression of
iron-responsive genes.
"In support of a Fur involvement, we found that with low iron
a Fur mutant was able to organize into more mature biofilms
than was the parent. The two known Fur-controlled small
regulatory RNAs (PrrF1 and
F2) do not appear to mediate iron control of biofilm
development.".
"This information," concluded investigators, "establishes a
mechanistic basis for iron control of P. aeruginosa biofilm
formation.".
Banin and colleagues published the results of their research
in Proceedings of the National Academy of Sciences of the
United States of America (Iron and Pseudomonas aeruginosa
biofilm formation. Proc Natl Acad Sci USA,
2005;102(31):11076-11081).
For additional information, contact E.P. Greenberg, University
of Washington, School of Medicine, Dept. Microbiology,
Seattle, WA 98195, USA.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk