Ironjustic
Sun, Aug-13-06, 17:16
Iron balance and iron-regulatory system alterations correlate
with HIV and TB disease progression Virus Weekly via NewsEdge
Corporation :. 2006 JUL 25 - (NewsRx.com) -- Iron balance and
iron-regulatory system alterations correlate with the
progression of HIV and tuberculosis disease.
According to a recent review from England, "There are many
lines of evidence illustrating that iron plays a pivotal role
in modulating the battle for survival between mammalian hosts
and their pathogens. Each displays considerable genetic
investment in a wide range of mechanisms for acquiring and
maintaining iron.
"These competitive mechanisms are highly complex, existing
within an interacting matrix of absorption, transport, storage
and detoxification systems, each of which are iron-responsive
and thus able to adapt to the different phases of infection.".
"Considerable genetic polymorphism in some of these systems,
with signals of geographic selection in the hosts, and niche
selection in the pathogens, indicates that they are critical
for species survival,"
J.M. McDermid and colleagues at the University London, London
School of Hygiene & Tropical Medicine wrote.
"In this review," said the authors, "we briefly summarize the
role of iron in host immune function before reviewing the
available evidence that iron modulates susceptibility and
disease outcomes in HIV and TB (tuberculosis).
"We then examine the putative role of iron-related host genes
by focusing on two candidate genes, haptoglobin and NRAMPI,
for which there are common polymorphic variants in humans with
strong evidence of functionally distinct biochemical
phenotypes that would be predicted to influence the course of
HIV and TB infections.".
"Finally," McDermid continued, "we examine the limited
evidence so far available that nutrient-gene interactions are
likely to influence the way in which gene variants can protect
against infection.".
Scientists concluded that there "a wealth of evidence
associating alterations in iron balance and in iron-regulatory
systems with disease progression, but that many issues related
to the direction of causality, mechanisms of action and
sensitivity to pharmacological intervention remain to be
elucidated.
"Since iron is probably the most widely prescribed compound
throughout the world, used in both preventative and treatment
regimens, a deeper understanding of the host-pathogen
interactions relating to iron constitutes an important area
for both basic and clinical research.".
McDermid and colleagues published the results of their
research in Clinical Science (Iron and infection: effects of
host iron status and the iron-regulatory genes haptoglobin and
NRAMPI (SLCIIAI) on host-pathogen interactions in tuberculosis
and HIV. Clin Sci (Lond), 2006;110(5):503-524).
For additional information, contact A.M. Prentice, University
of London London School Hyg & Trop Med, Medical Research
Council, International Nutrition Group, Keppel St., London
WC1E 7HT, England.
The publisher of the journal Clinical Science can be contacted
at: Portland Press Ltd., Third Floor, Eagle House, 16 Procter
Street, London WC1V 6 Nx, England.
Keywords: London, England, HIV/AIDS, Tuberculosis, Iron
Regulatory Genes, Host Immune Function, Iron Balance.
This article was prepared by Virus Weekly editors from staff
and other reports. Copyright 2006, Virus Weekly via
NewsRx.com.
<<Virus Weekly -- 07/26/06>>.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
with HIV and TB disease progression Virus Weekly via NewsEdge
Corporation :. 2006 JUL 25 - (NewsRx.com) -- Iron balance and
iron-regulatory system alterations correlate with the
progression of HIV and tuberculosis disease.
According to a recent review from England, "There are many
lines of evidence illustrating that iron plays a pivotal role
in modulating the battle for survival between mammalian hosts
and their pathogens. Each displays considerable genetic
investment in a wide range of mechanisms for acquiring and
maintaining iron.
"These competitive mechanisms are highly complex, existing
within an interacting matrix of absorption, transport, storage
and detoxification systems, each of which are iron-responsive
and thus able to adapt to the different phases of infection.".
"Considerable genetic polymorphism in some of these systems,
with signals of geographic selection in the hosts, and niche
selection in the pathogens, indicates that they are critical
for species survival,"
J.M. McDermid and colleagues at the University London, London
School of Hygiene & Tropical Medicine wrote.
"In this review," said the authors, "we briefly summarize the
role of iron in host immune function before reviewing the
available evidence that iron modulates susceptibility and
disease outcomes in HIV and TB (tuberculosis).
"We then examine the putative role of iron-related host genes
by focusing on two candidate genes, haptoglobin and NRAMPI,
for which there are common polymorphic variants in humans with
strong evidence of functionally distinct biochemical
phenotypes that would be predicted to influence the course of
HIV and TB infections.".
"Finally," McDermid continued, "we examine the limited
evidence so far available that nutrient-gene interactions are
likely to influence the way in which gene variants can protect
against infection.".
Scientists concluded that there "a wealth of evidence
associating alterations in iron balance and in iron-regulatory
systems with disease progression, but that many issues related
to the direction of causality, mechanisms of action and
sensitivity to pharmacological intervention remain to be
elucidated.
"Since iron is probably the most widely prescribed compound
throughout the world, used in both preventative and treatment
regimens, a deeper understanding of the host-pathogen
interactions relating to iron constitutes an important area
for both basic and clinical research.".
McDermid and colleagues published the results of their
research in Clinical Science (Iron and infection: effects of
host iron status and the iron-regulatory genes haptoglobin and
NRAMPI (SLCIIAI) on host-pathogen interactions in tuberculosis
and HIV. Clin Sci (Lond), 2006;110(5):503-524).
For additional information, contact A.M. Prentice, University
of London London School Hyg & Trop Med, Medical Research
Council, International Nutrition Group, Keppel St., London
WC1E 7HT, England.
The publisher of the journal Clinical Science can be contacted
at: Portland Press Ltd., Third Floor, Eagle House, 16 Procter
Street, London WC1V 6 Nx, England.
Keywords: London, England, HIV/AIDS, Tuberculosis, Iron
Regulatory Genes, Host Immune Function, Iron Balance.
This article was prepared by Virus Weekly editors from staff
and other reports. Copyright 2006, Virus Weekly via
NewsRx.com.
<<Virus Weekly -- 07/26/06>>.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk