Ironjustic
Sat, Aug-12-06, 17:15
<<snip>> This is the first report to show that serum ferritin
is associated with circulating oxLDL levels in patients with
type 2 diabetes <<snip>>
Association between Serum Ferritin and Circulating Oxidized
Low-density Lipoprotein Levels in Patients with Type 2
Diabetes. Ikeda Y, Suehiro T, Yamanaka S, Kumon Y, Takata H,
Inada S, Ogami N, Osaki F, Inoue M, Arii K, Hashimoto K Endocr
J. 2006 Aug 11;
The oxidative modification of low-density lipoproteins (LDL)
plays a central role in the initiation and acceleration of
atherosclerosis. Iron plays a part in the formation of highly
toxic free radicals such as hydroxide and superoxide anions,
which can induce lipid peroxidation. We investigated whether
serum iron status was associated with circulating oxidized LDL
(oxLDL) levels in type 2 diabetic patients, in whom oxidative
stress and susceptibility to lipid oxidation were supposedly
increased. Serum ferritin levels were significantly correlated
with plasma oxLDL concentrations in both male and female
patients (p<0.02 and p<0.05, respectively). No correlation was
detected between ferritin and LDL-cholesterol (LDL-C)
concentrations despite the close correlation between LDL-C and
oxLDL concentrations (p<0.0001). Stepwise regression analysis
showed that ferritin concentration was an independent positive
determinant of oxLDL level, in addition to triglyceride
concentration, body mass index and sex. This is the first
report to show that serum ferritin is associated with
circulating oxLDL levels in patients with type 2 diabetes.
Further work is required to establish a causative link between
iron excess and the development of diabetic vascular
complications.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
is associated with circulating oxLDL levels in patients with
type 2 diabetes <<snip>>
Association between Serum Ferritin and Circulating Oxidized
Low-density Lipoprotein Levels in Patients with Type 2
Diabetes. Ikeda Y, Suehiro T, Yamanaka S, Kumon Y, Takata H,
Inada S, Ogami N, Osaki F, Inoue M, Arii K, Hashimoto K Endocr
J. 2006 Aug 11;
The oxidative modification of low-density lipoproteins (LDL)
plays a central role in the initiation and acceleration of
atherosclerosis. Iron plays a part in the formation of highly
toxic free radicals such as hydroxide and superoxide anions,
which can induce lipid peroxidation. We investigated whether
serum iron status was associated with circulating oxidized LDL
(oxLDL) levels in type 2 diabetic patients, in whom oxidative
stress and susceptibility to lipid oxidation were supposedly
increased. Serum ferritin levels were significantly correlated
with plasma oxLDL concentrations in both male and female
patients (p<0.02 and p<0.05, respectively). No correlation was
detected between ferritin and LDL-cholesterol (LDL-C)
concentrations despite the close correlation between LDL-C and
oxLDL concentrations (p<0.0001). Stepwise regression analysis
showed that ferritin concentration was an independent positive
determinant of oxLDL level, in addition to triglyceride
concentration, body mass index and sex. This is the first
report to show that serum ferritin is associated with
circulating oxLDL levels in patients with type 2 diabetes.
Further work is required to establish a causative link between
iron excess and the development of diabetic vascular
complications.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk