Ironjustic
Sat, Aug-12-06, 06:15
<<snip>> supports the conclusion that oxidative stress may be
one of the important causes for abnormal endometrial
environment with poor embryo receptivity <<snip>>
The presence of antibodies to oxidative modified proteins in
serum from polycystic ovary syndrome patients. Palacio JR,
Iborra A, Ulcova-Gallova Z, Badia R, Mart=EDnez P Clin Exp
Immunol. 2006 May ; 144(2): 217-22
Polycystic ovary syndrome (PCOS) affects 5-10% of women of
reproductive age. Free radicals, as a product of oxidative
stress, impair cells and tissue properties related to human
fertility. These free radicals, together with the oxidized
molecules, may have a cytotoxic or deleterious effects on
sperm and oocytes, on early embryo development or on the
endometrium. Aldehyde-modified proteins are highly immunogenic
and circulating autoantibodies to new epitopes, such as
malondialdehyde (MDA), may affect the reproductive system.
Autoantibodies or elevated reactive oxygen species (ROS) in
serum are often associated with inflammatory response. The
purpose of this work is to investigate whether PCOS women show
increased levels of oxidized proteins (protein-MDA) and
anti-endometrial antibodies (AEA) in their sera, compared with
control patients, and to determine whether AEA specificity is
related to oxidized protein derivatives. Sera from 31 women
[10 patients with PCOS (PCOS group) and 21 women with male
factor of infertility (control group)] were chosen from
patients attending for infertility. Anti-endometrial
antibodies were determined by enzyme-linked immunosorbent
assay (ELISA) with an endometrial cell line (RL-95).
Antibodies against MDA modified human serum albumin (HSA-MDA)
were also determined by ELISA. Oxidized proteins (protein-MDA)
in serum were determined by a colorimetric assay. Patients
with PCOS have significantly higher levels of AEA and
anti-HSA-MDA, as well as oxidized proteins (protein-MDA) in
serum than control patients. For the first time, we describe
an autoimmune response in PCOS patients, in terms of AEA. The
evidence of protein-MDA in the serum of these patients,
together with the increased antibody reactivity to
MDA-modified proteins (HSA-MDA) in vitro, supports the
conclusion that oxidative stress may be one of the important
causes for abnormal endometrial environment with poor embryo
receptivity in PCOS patients.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk
one of the important causes for abnormal endometrial
environment with poor embryo receptivity <<snip>>
The presence of antibodies to oxidative modified proteins in
serum from polycystic ovary syndrome patients. Palacio JR,
Iborra A, Ulcova-Gallova Z, Badia R, Mart=EDnez P Clin Exp
Immunol. 2006 May ; 144(2): 217-22
Polycystic ovary syndrome (PCOS) affects 5-10% of women of
reproductive age. Free radicals, as a product of oxidative
stress, impair cells and tissue properties related to human
fertility. These free radicals, together with the oxidized
molecules, may have a cytotoxic or deleterious effects on
sperm and oocytes, on early embryo development or on the
endometrium. Aldehyde-modified proteins are highly immunogenic
and circulating autoantibodies to new epitopes, such as
malondialdehyde (MDA), may affect the reproductive system.
Autoantibodies or elevated reactive oxygen species (ROS) in
serum are often associated with inflammatory response. The
purpose of this work is to investigate whether PCOS women show
increased levels of oxidized proteins (protein-MDA) and
anti-endometrial antibodies (AEA) in their sera, compared with
control patients, and to determine whether AEA specificity is
related to oxidized protein derivatives. Sera from 31 women
[10 patients with PCOS (PCOS group) and 21 women with male
factor of infertility (control group)] were chosen from
patients attending for infertility. Anti-endometrial
antibodies were determined by enzyme-linked immunosorbent
assay (ELISA) with an endometrial cell line (RL-95).
Antibodies against MDA modified human serum albumin (HSA-MDA)
were also determined by ELISA. Oxidized proteins (protein-MDA)
in serum were determined by a colorimetric assay. Patients
with PCOS have significantly higher levels of AEA and
anti-HSA-MDA, as well as oxidized proteins (protein-MDA) in
serum than control patients. For the first time, we describe
an autoimmune response in PCOS patients, in terms of AEA. The
evidence of protein-MDA in the serum of these patients,
together with the increased antibody reactivity to
MDA-modified proteins (HSA-MDA) in vitro, supports the
conclusion that oxidative stress may be one of the important
causes for abnormal endometrial environment with poor embryo
receptivity in PCOS patients.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk