Ironjustic
Fri, Aug-11-06, 17:15
Iron overload leads to pathological viscosity
Hemorheological status and redox homeostasis of phlebotomised
porphyria cutanea tarda patients with diabetes mellitus and in
moderate alcohol consumer. Sz=E9kely E, Bor M, Tasn=E1di G,
V=E1rnai K, Alm=E1si A, Bl=E1zovics A Clin Hemorheol
Microcirc. 2006; 35(3): 387-96
Increase in porphyrin concentration is caused by the
decreased activity of uroporphyrinogen decarboxylase in
porphyria cutanea tarda (PCT). Iron overload, alcohol
consumption and diabetes mellitus play role in the
development of PCT. We investigated the hemorheological and
redox-parameters from the blood of 34 male PCT patients and
10 male volunteers. The disfunctions were investigated by
pathological amounts of iron and lipid metabolism. Routine
laboratory and hemorheological parameters, plasma free
SH-group concentration, H-donating ability and reducing
power were measured by spectrophotometry. Free radical
activity was determined by chemiluminometry method. The
hemorheological parameters were significantly increased in
all three groups of PCT patients compared to the controls.
Negative correlations were observed between blood viscosity
and antioxidant defence of PCT patients and in PCT patients
with alcohol consumption. Plasma and erythrocyte
chemiluminescent intensity was higher in PCT patients than
in controls, which indicated the decrease of antioxidant
defence. Hemorheological parameters were highest in
patients with diabetes and in alcohol consumers. Iron
overload increased free radical reactions in PCT patients,
leading to pathological viscosity. Increased free radical
reactions and high blood viscosity increase the risk of
cardiovascular diseases.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk
Hemorheological status and redox homeostasis of phlebotomised
porphyria cutanea tarda patients with diabetes mellitus and in
moderate alcohol consumer. Sz=E9kely E, Bor M, Tasn=E1di G,
V=E1rnai K, Alm=E1si A, Bl=E1zovics A Clin Hemorheol
Microcirc. 2006; 35(3): 387-96
Increase in porphyrin concentration is caused by the
decreased activity of uroporphyrinogen decarboxylase in
porphyria cutanea tarda (PCT). Iron overload, alcohol
consumption and diabetes mellitus play role in the
development of PCT. We investigated the hemorheological and
redox-parameters from the blood of 34 male PCT patients and
10 male volunteers. The disfunctions were investigated by
pathological amounts of iron and lipid metabolism. Routine
laboratory and hemorheological parameters, plasma free
SH-group concentration, H-donating ability and reducing
power were measured by spectrophotometry. Free radical
activity was determined by chemiluminometry method. The
hemorheological parameters were significantly increased in
all three groups of PCT patients compared to the controls.
Negative correlations were observed between blood viscosity
and antioxidant defence of PCT patients and in PCT patients
with alcohol consumption. Plasma and erythrocyte
chemiluminescent intensity was higher in PCT patients than
in controls, which indicated the decrease of antioxidant
defence. Hemorheological parameters were highest in
patients with diabetes and in alcohol consumers. Iron
overload increased free radical reactions in PCT patients,
leading to pathological viscosity. Increased free radical
reactions and high blood viscosity increase the risk of
cardiovascular diseases.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk