Ironjustic
Thu, Jul-13-06, 06:20
<<snip>> patients with indicators of oxidative dysfunction
developed delirium more frequently, <<snip>>
Psychosomatics 47:56-61, February 2006 doi:
10.1176/appi.psy.47.1.56 =A9 2006 Academy of
Psychosomatic Medicine
Delirium
Syndromes Secondary to General Medical Disorders
Impaired Oxidative Metabolism Precipitates Delirium: A Study
of 101 ICU Patients Jeff S. Seaman, M.S., M.D., Jason
Schillerstrom, M.D., David Carroll, R=2EN., M.S.N., and Thomas
M. Brown, M.D. Received July 13, 2004; revised February 14,
2005; accepted March 7, 2005. From the University of Oklahoma
Health Sciences Center (JSS); the Department of Psychiatry,
University of Texas Health Sciences Center, San Antonio (JS);
Wilford Hall Medical Center, Lackland Air Force Base, TX (DC);
and the Department of Psychiatry, Audrey Murphy Veterans
Hospital, San Antonio, TX (TMB). Address correspondence and
reprint requests to Dr. Seaman, OUHSC Dept of Psychiatry, P.O.
Box 26901, OK City, OK 73190. e-mail: jeff-seaman@ouhsc.edu
Data from 101 consecutively admitted intensive care unit (ICU)
patients were examined to determine whether oxidative
metabolic stress existed within the 48 hours before delirium
onset. The occurrence of pneumonia and sepsis at any time
during hospitalization was also recorded. Delirium was defined
retrospectively with the Confusion Assessment Method (CAM).
Older patients were found to develop delirium more frequently
than younger patients. There were no differences in illness
severity (APACHE II) between those who developed delirium and
those who did not. Three measures of oxygenation (hemoglobin,
hematocrit, pulse oximetry) were worse in the patients who
later developed delirium. Two measures of oxidative stress
(sepsis, pneumonia) occurred more frequently among those
diagnosed with delirium. Hence, patients with indicators of
oxidative dysfunction developed delirium more frequently, and
this was not linked to illness severity.
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HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH SEARCH
RESULT Copyright =A9 2006 Academy of Psychosomatic Medicine
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk
developed delirium more frequently, <<snip>>
Psychosomatics 47:56-61, February 2006 doi:
10.1176/appi.psy.47.1.56 =A9 2006 Academy of
Psychosomatic Medicine
Delirium
Syndromes Secondary to General Medical Disorders
Impaired Oxidative Metabolism Precipitates Delirium: A Study
of 101 ICU Patients Jeff S. Seaman, M.S., M.D., Jason
Schillerstrom, M.D., David Carroll, R=2EN., M.S.N., and Thomas
M. Brown, M.D. Received July 13, 2004; revised February 14,
2005; accepted March 7, 2005. From the University of Oklahoma
Health Sciences Center (JSS); the Department of Psychiatry,
University of Texas Health Sciences Center, San Antonio (JS);
Wilford Hall Medical Center, Lackland Air Force Base, TX (DC);
and the Department of Psychiatry, Audrey Murphy Veterans
Hospital, San Antonio, TX (TMB). Address correspondence and
reprint requests to Dr. Seaman, OUHSC Dept of Psychiatry, P.O.
Box 26901, OK City, OK 73190. e-mail: jeff-seaman@ouhsc.edu
Data from 101 consecutively admitted intensive care unit (ICU)
patients were examined to determine whether oxidative
metabolic stress existed within the 48 hours before delirium
onset. The occurrence of pneumonia and sepsis at any time
during hospitalization was also recorded. Delirium was defined
retrospectively with the Confusion Assessment Method (CAM).
Older patients were found to develop delirium more frequently
than younger patients. There were no differences in illness
severity (APACHE II) between those who developed delirium and
those who did not. Three measures of oxygenation (hemoglobin,
hematocrit, pulse oximetry) were worse in the patients who
later developed delirium. Two measures of oxidative stress
(sepsis, pneumonia) occurred more frequently among those
diagnosed with delirium. Hence, patients with indicators of
oxidative dysfunction developed delirium more frequently, and
this was not linked to illness severity.
--------------------------------------------------------------
--------------=
-----
HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH SEARCH
RESULT Copyright =A9 2006 Academy of Psychosomatic Medicine
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20 http://tinyurl.com/zk9fk