Ironjustic
Fri, Jun-23-06, 06:15
Iron Chelation as Therapy for HIV and Mycobacterium
tuberculosis Co-Infection Under Conditions of Iron Overload.
Meyer D Curr Pharm Des. 2006; 12(16): 1943-7
Iron chelators, as treatment for conditions of iron overload,
have implications for AIDS and tuberculosis (TB) since excess
iron in the system assists HIV and Mycobacterium tuberculosis
(M.tb) multiplication. Excess iron, especially due to dietary
habits, is almost as common in sub-Saharan Africa as
infections by the two organisms. That HIV and M.tb influence
each other's replication during co-infection is well
established, but in vitro evaluations of concurrent infection
of the two under conditions of iron overload and determining
whether chelators reverse the effect, are limited. This review
provides brief commentary on the possibility of iron chelators
presently in clinical use influencing simultaneous HIV-M.tb
infections during iron loading and the feasibility of
evaluating this in vitro
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
tuberculosis Co-Infection Under Conditions of Iron Overload.
Meyer D Curr Pharm Des. 2006; 12(16): 1943-7
Iron chelators, as treatment for conditions of iron overload,
have implications for AIDS and tuberculosis (TB) since excess
iron in the system assists HIV and Mycobacterium tuberculosis
(M.tb) multiplication. Excess iron, especially due to dietary
habits, is almost as common in sub-Saharan Africa as
infections by the two organisms. That HIV and M.tb influence
each other's replication during co-infection is well
established, but in vitro evaluations of concurrent infection
of the two under conditions of iron overload and determining
whether chelators reverse the effect, are limited. This review
provides brief commentary on the possibility of iron chelators
presently in clinical use influencing simultaneous HIV-M.tb
infections during iron loading and the feasibility of
evaluating this in vitro
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk