Ironjustic
Sat, Mar-11-06, 17:16
Eur J Pharmacol. 2006 Mar 6; Zhang Y, Li H, Zhao Y, Gao Z
The introduction of new iron chelating drugs may ultimately
improve iron-chelation therapy for patients with iron overload
diseases such as thalassaemia and other disorders. In this
paper, the in vivo effects of baicalin and quercetin on iron
overload induced liver injury were studied on
mice. It was found that when iron-dextran induced iron
overload mice were fed baicalin or quercetin containing
diet (1% w/w) for 45days, both flavonoids significantly
inhibited iron overload induced lipid peroxidation and
protein oxidation of liver, decreased hepatic iron and
hepatic collagen content, increased the serum non-heme
iron level but not serum ferritin level. Flavonoids
supplementation also increased the excretion of iron
through feces. In vitro study demonstrated that both
flavonoids could release iron from ferritin. These
results indicate that besides acting as antioxidants,
both flavonoids can also release iron from liver and
finally excrete it through feces. The present study
provides further support for flavonoids to be medicines
for iron overload diseases.
Read more <">http://www.hubmed.org/display.cgi?uids=16527270>
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
The introduction of new iron chelating drugs may ultimately
improve iron-chelation therapy for patients with iron overload
diseases such as thalassaemia and other disorders. In this
paper, the in vivo effects of baicalin and quercetin on iron
overload induced liver injury were studied on
mice. It was found that when iron-dextran induced iron
overload mice were fed baicalin or quercetin containing
diet (1% w/w) for 45days, both flavonoids significantly
inhibited iron overload induced lipid peroxidation and
protein oxidation of liver, decreased hepatic iron and
hepatic collagen content, increased the serum non-heme
iron level but not serum ferritin level. Flavonoids
supplementation also increased the excretion of iron
through feces. In vitro study demonstrated that both
flavonoids could release iron from ferritin. These
results indicate that besides acting as antioxidants,
both flavonoids can also release iron from liver and
finally excrete it through feces. The present study
provides further support for flavonoids to be medicines
for iron overload diseases.
Read more <">http://www.hubmed.org/display.cgi?uids=16527270>
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking