Ironjustic
Mon, Jan-23-06, 17:16
These results strongly suggest that P. brasiliensis survival
in human monocytes is iron dependent.
Rev Inst Med Trop Sao Paulo. 2005 Sep-Oct;47(5):263-6.
Epub 2005 Nov
16. Related Articles, Links
Inhibitory effect of deferoxamine on Paracoccidioides
brasiliensis survival in human monocytes: reversal by
holotransferrin not by apotransferrin.
Dias-Melicio LA, Calvi SA, Peracoli MT, Soares AM.
Department of Microbiology and Immunology, Biosciences
Institute, Sao Paulo State University, Botucatu, SP, Brazil.
acsoares@ibb.unesp.br
The mechanisms used by Paracoccidioides brasiliensis to
survive into phagocytic cells are not clear. Cellular iron
metabolism is of critical importance to the growth of several
intracellular pathogens whose capacity to multiply in
mononuclear phagocytes is dependent on the availability of
intracellular iron. Thus, the objective of this paper was to
investigate the role of intracellular iron in regulating the
capacity of P. brasiliensis yeast cells to survive within
human monocytes. Treatment of monocytes with deferoxamine, an
iron chelator, suppressed the survival of yeasts in a
concentration-dependent manner. The effect of deferoxamine was
reversed by iron-saturated transferrin (holotransferrin) but
not by nonsaturated transferrin (apotransferrin). These
results strongly suggest that P. brasiliensis survival in
human monocytes is iron dependent.
PMID: 16302109 [PubMed - in process]
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Osteomyelitis Caused by Paracoccidioides brasiliensis in a
Child from the Metropolitan Area of Rio de Janeiro Authors:
Nogueira S.A.1; Guedes A.L.2; Wanke B.3; Capella S.4;
Rodrigues K.1; Abreu T.F.2; Morais J.C.1; Lambert J.S.3
Source: Journal of Tropical Pediatrics, Volume 47, Number 5, 1
October 2001, pp. 311-315(5)
Publisher:Oxford University Press
< previous article | next article > View Table of Contents
full text options
Abstract:
The authors describe a case of paracoccidioidomycosis in a
7-year-old girl from the city of Rio de Janeiro who initially
presented to her physician with a lesion in her calcaneous
which was misdiagnosed and treated as bacterial osteomyelitis.
Later, cutaneous manifestations, lymph node enlargement, and
hepatosplenomegaly developed and biopsy of the skin and
cervical lymph nodes showed the fungus which was also present
in the sputum. It is emphasized that Paracoccidioides
brasiliensis can be the cause of bone lesions in endemic areas
of Latin America and that response to treatment with
amphotericin B is good. Document Type: Research article
DOI: 10.1093/tropej/47.5.311
Affiliations: 1: Hospital Universit=E1rio Clementino Fraga
Filho, Servi=E7o de Doen=E7as Infecciosas e Parasit=E1rias,
University Federal do Rio de Janeiro, Brazil 2: Institute
Puericultura e Pediatria Matarg=E3o, University Federal do Rio
de Janeiro, Brazil 3: Institute of Human Virology, University
of Maryland, USA 4: Hospital Municipal Salgado Filho, Brazil
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
in human monocytes is iron dependent.
Rev Inst Med Trop Sao Paulo. 2005 Sep-Oct;47(5):263-6.
Epub 2005 Nov
16. Related Articles, Links
Inhibitory effect of deferoxamine on Paracoccidioides
brasiliensis survival in human monocytes: reversal by
holotransferrin not by apotransferrin.
Dias-Melicio LA, Calvi SA, Peracoli MT, Soares AM.
Department of Microbiology and Immunology, Biosciences
Institute, Sao Paulo State University, Botucatu, SP, Brazil.
acsoares@ibb.unesp.br
The mechanisms used by Paracoccidioides brasiliensis to
survive into phagocytic cells are not clear. Cellular iron
metabolism is of critical importance to the growth of several
intracellular pathogens whose capacity to multiply in
mononuclear phagocytes is dependent on the availability of
intracellular iron. Thus, the objective of this paper was to
investigate the role of intracellular iron in regulating the
capacity of P. brasiliensis yeast cells to survive within
human monocytes. Treatment of monocytes with deferoxamine, an
iron chelator, suppressed the survival of yeasts in a
concentration-dependent manner. The effect of deferoxamine was
reversed by iron-saturated transferrin (holotransferrin) but
not by nonsaturated transferrin (apotransferrin). These
results strongly suggest that P. brasiliensis survival in
human monocytes is iron dependent.
PMID: 16302109 [PubMed - in process]
--------------------------------------------------------------
--------------=
-----
Osteomyelitis Caused by Paracoccidioides brasiliensis in a
Child from the Metropolitan Area of Rio de Janeiro Authors:
Nogueira S.A.1; Guedes A.L.2; Wanke B.3; Capella S.4;
Rodrigues K.1; Abreu T.F.2; Morais J.C.1; Lambert J.S.3
Source: Journal of Tropical Pediatrics, Volume 47, Number 5, 1
October 2001, pp. 311-315(5)
Publisher:Oxford University Press
< previous article | next article > View Table of Contents
full text options
Abstract:
The authors describe a case of paracoccidioidomycosis in a
7-year-old girl from the city of Rio de Janeiro who initially
presented to her physician with a lesion in her calcaneous
which was misdiagnosed and treated as bacterial osteomyelitis.
Later, cutaneous manifestations, lymph node enlargement, and
hepatosplenomegaly developed and biopsy of the skin and
cervical lymph nodes showed the fungus which was also present
in the sputum. It is emphasized that Paracoccidioides
brasiliensis can be the cause of bone lesions in endemic areas
of Latin America and that response to treatment with
amphotericin B is good. Document Type: Research article
DOI: 10.1093/tropej/47.5.311
Affiliations: 1: Hospital Universit=E1rio Clementino Fraga
Filho, Servi=E7o de Doen=E7as Infecciosas e Parasit=E1rias,
University Federal do Rio de Janeiro, Brazil 2: Institute
Puericultura e Pediatria Matarg=E3o, University Federal do Rio
de Janeiro, Brazil 3: Institute of Human Virology, University
of Maryland, USA 4: Hospital Municipal Salgado Filho, Brazil
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking