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Mon, Jan-23-06, 06:15
Nutrition. 2006 Jan 12; [Epub ahead of print] Related
Articles, Links
Oral creatine supplementation in humans does not elevate
urinary excretion of the carcinogen N-nitrososarcosine.
Derave W, Vanden Eede E, Hespel P, Carmella SG, Hecht SS.
Research Unit of Exercise and Health, Faculty of Kinesiology
and Rehabilitation Sciences, Leuven, Belgium.
OBJECTIVE: Creatine is a popular oral supplement in athletes
and may have therapeutical potential in neuromuscular
diseases. It has been hypothesized that creatine ingestion can
lead to increased formation of the carcinogen
N-nitrososarcosine. METHODS: We investigated in a
double-blind, placebo-controlled study the urinary excretion
of N-nitrososarcosine after 1-wk high-dose (20 g/d) and 20-wk
low-dose (5
g/d) creatine supplementation in healthy humans. RESULTS AND
CONCLUSION: Creatine ingestion does not systematically
increase urinary N-nitrososarcosine excretion.
PMID: 16413752 [PubMed - as supplied by publisher]
Articles, Links
Oral creatine supplementation in humans does not elevate
urinary excretion of the carcinogen N-nitrososarcosine.
Derave W, Vanden Eede E, Hespel P, Carmella SG, Hecht SS.
Research Unit of Exercise and Health, Faculty of Kinesiology
and Rehabilitation Sciences, Leuven, Belgium.
OBJECTIVE: Creatine is a popular oral supplement in athletes
and may have therapeutical potential in neuromuscular
diseases. It has been hypothesized that creatine ingestion can
lead to increased formation of the carcinogen
N-nitrososarcosine. METHODS: We investigated in a
double-blind, placebo-controlled study the urinary excretion
of N-nitrososarcosine after 1-wk high-dose (20 g/d) and 20-wk
low-dose (5
g/d) creatine supplementation in healthy humans. RESULTS AND
CONCLUSION: Creatine ingestion does not systematically
increase urinary N-nitrososarcosine excretion.
PMID: 16413752 [PubMed - as supplied by publisher]