Ironjustic
Sun, Jan-22-06, 17:16
<<snip>> Severe fibrosis and cirrhosis were associated more
markedly with the presence of hemosiderin iron <<snip>>
Am J Clin Pathol. 2005 Dec;124(6):846-53. Related
Articles, Links
Iron accumulation in chronic hepatitis C: relation of hepatic
iron distribution, HFE genotype, and disease course.
Corengia C, Galimberti S, Bovo G, Vergani A, Arosio C, Mariani
R, Redaelli A, Riva A, Cestari C, Pozzi M, Valsecchi MG,
Piperno A.
Unit of Clinical Medicine, Department of Clinical Medicine,
Prevention and Biotechnologies, University of Milano-Bicocca,
San Gerardo Hospital, Monza, Italy.
The aim of the present study was to describe the
histopathologic features of hepatic iron accumulation in
patients with chronic hepatitis C (CH-C) infection, the
relation between HFE mutations and hepatic iron location and
among iron distribution, HFE, and hepatic damage. We studied
206 patients with CH-C infection. Of 101 patients with
hemosiderin deposits, 90.1% had iron deposits in hepatocytes
(alone or with sinusoidal and/or portal involvement). The
hepatic iron score increased significantly as iron
accumulation involved sinusoidal and portal tract compartments
and according to HFE genotypes. Severe fibrosis and cirrhosis
were associated more markedly with the presence of hemosiderin
iron in the 3 hepatic compartments, HFE mutations, and high
alcohol intake. We suggest that part of the iron accumulation
in CH-C infection derives from increased iron absorption and
release from storage cells and that the amount and
distribution of hepatic iron deposits is related to hepatic
damage. HFE mutations favor both processes, but other factors,
genetic or acquired, are involved.
PMID: 16416733 [PubMed - in process]
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Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
markedly with the presence of hemosiderin iron <<snip>>
Am J Clin Pathol. 2005 Dec;124(6):846-53. Related
Articles, Links
Iron accumulation in chronic hepatitis C: relation of hepatic
iron distribution, HFE genotype, and disease course.
Corengia C, Galimberti S, Bovo G, Vergani A, Arosio C, Mariani
R, Redaelli A, Riva A, Cestari C, Pozzi M, Valsecchi MG,
Piperno A.
Unit of Clinical Medicine, Department of Clinical Medicine,
Prevention and Biotechnologies, University of Milano-Bicocca,
San Gerardo Hospital, Monza, Italy.
The aim of the present study was to describe the
histopathologic features of hepatic iron accumulation in
patients with chronic hepatitis C (CH-C) infection, the
relation between HFE mutations and hepatic iron location and
among iron distribution, HFE, and hepatic damage. We studied
206 patients with CH-C infection. Of 101 patients with
hemosiderin deposits, 90.1% had iron deposits in hepatocytes
(alone or with sinusoidal and/or portal involvement). The
hepatic iron score increased significantly as iron
accumulation involved sinusoidal and portal tract compartments
and according to HFE genotypes. Severe fibrosis and cirrhosis
were associated more markedly with the presence of hemosiderin
iron in the 3 hepatic compartments, HFE mutations, and high
alcohol intake. We suggest that part of the iron accumulation
in CH-C infection derives from increased iron absorption and
release from storage cells and that the amount and
distribution of hepatic iron deposits is related to hepatic
damage. HFE mutations favor both processes, but other factors,
genetic or acquired, are involved.
PMID: 16416733 [PubMed - in process]
--------------------------------------------------------------
-------------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking