Ironjustic
Wed, Dec-14-05, 06:15
<<snip>> The results of these reports suggest that some
patients with CFS should be treated with specific
antioxidants, including zinc supplements <<snip>>
1: J Affect Disord. 2005 Dec 7; [Epub ahead of print] Links
Lower serum zinc in Chronic Fatigue Syndrome (CFS):
Relationships to immune dysfunctions and relevance for the
oxidative stress status in CFS.
Maes M, Mihaylova I, De Ruyter M.
M-Care4U Outpatient Clinics, Olmenlaan 9, 2610
Antwerp-Wilrijk, Belgium; Clinical Research Center for Mental
Health, Olmenlaan 9, Wilrijk, Belgium; Department of
Psychiatry, Vanderbilt University, Nashville TN, USA.
The present study examines serum zinc concentrations in
patients with chronic fatigue syndrome (CFS) versus normal
volunteers. Serum zinc levels were determined by means of an
atomic absorption method. We found that serum zinc was
significantly lower in the CFS patients than in the normal
controls. There was a trend toward a significant negative
correlation between serum zinc and the severity of CFS and
there was a significant and negative correlation between serum
zinc and the subjective experience of infection. We found that
serum zinc was significantly and negatively correlated to the
increase in the alpha2 protein fraction and positively
correlated to decreases in the expression of mitogen-induced
CD69+ (a T cell activation marker) on CD3+ as well as CD3+CD8+
T cells. These results show that CFS is accompanied by a low
serum zinc status and that the latter is related to signs of
inflammation and defects in early T cell activation pathways.
Since zinc is a strong anti-oxidant, the present results
further support the findings that CFS is accompanied by
increased oxidative stress. The results of these reports
suggest that some patients with CFS should be treated with
specific antioxidants, including zinc supplements.
PMID: 16338007 [PubMed - as supplied by publisher]
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patients with CFS should be treated with specific
antioxidants, including zinc supplements <<snip>>
1: J Affect Disord. 2005 Dec 7; [Epub ahead of print] Links
Lower serum zinc in Chronic Fatigue Syndrome (CFS):
Relationships to immune dysfunctions and relevance for the
oxidative stress status in CFS.
Maes M, Mihaylova I, De Ruyter M.
M-Care4U Outpatient Clinics, Olmenlaan 9, 2610
Antwerp-Wilrijk, Belgium; Clinical Research Center for Mental
Health, Olmenlaan 9, Wilrijk, Belgium; Department of
Psychiatry, Vanderbilt University, Nashville TN, USA.
The present study examines serum zinc concentrations in
patients with chronic fatigue syndrome (CFS) versus normal
volunteers. Serum zinc levels were determined by means of an
atomic absorption method. We found that serum zinc was
significantly lower in the CFS patients than in the normal
controls. There was a trend toward a significant negative
correlation between serum zinc and the severity of CFS and
there was a significant and negative correlation between serum
zinc and the subjective experience of infection. We found that
serum zinc was significantly and negatively correlated to the
increase in the alpha2 protein fraction and positively
correlated to decreases in the expression of mitogen-induced
CD69+ (a T cell activation marker) on CD3+ as well as CD3+CD8+
T cells. These results show that CFS is accompanied by a low
serum zinc status and that the latter is related to signs of
inflammation and defects in early T cell activation pathways.
Since zinc is a strong anti-oxidant, the present results
further support the findings that CFS is accompanied by
increased oxidative stress. The results of these reports
suggest that some patients with CFS should be treated with
specific antioxidants, including zinc supplements.
PMID: 16338007 [PubMed - as supplied by publisher]
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