Ironjustic
Fri, Nov-04-05, 17:16
Liposomalization of lactoferrin enhanced it's
anti-inflammatory effects via oral administration. Ishikado A,
Imanaka H, Takeuchi T, Harada E, Makino T Biol Pharm Bull.
2005 Sep ; 28(9): 1717-21
It is known that lactoferrin is one of the functional proteins
contained in mammalian milk and that it plays an important
role in the immune system. In this study, we prepared
multi-lamellar liposomal bovine lactoferrin composed of egg
yolk phosphatidylcholine and phytosterol for oral delivery,
and examined any resulting anti-inflammatory effects. Oral
pretreatment of liposomal lactoferrin exhibited more
suppressive effects than did non-liposomal lactoferrin on
CCl4-induced hepatic injury in rats as well as on
lipopolysaccharide-induced TNF-alpha production from mouse
peripheral blood mononuclear leukocytes. Further investigation
revealed that the liposomalization did not exert influence on
the absorbability of lactoferrin to the venous blood or lymph
following an intraduodenal administration in rats.
Furthermore, there was no significant difference exhibited
between the antigenicity of liposomal and non-liposomal
lactoferrin, which was measured using the passive cutaneous
anaphylaxis reaction following oral sensitization to them in
guinea pigs. These results suggest that liposomal lactoferrin
might act more effectively than conventional lactoferrin in
the intestinal site, which is regarded as an active site of
orally administered lactoferrin, although the biological
mechanism is not fully understood yet. Consequently we propose
that liposomal lactoferrin could be a novel active constituent
useful for preventive and therapeutic treatment of
inflammatory diseases.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
anti-inflammatory effects via oral administration. Ishikado A,
Imanaka H, Takeuchi T, Harada E, Makino T Biol Pharm Bull.
2005 Sep ; 28(9): 1717-21
It is known that lactoferrin is one of the functional proteins
contained in mammalian milk and that it plays an important
role in the immune system. In this study, we prepared
multi-lamellar liposomal bovine lactoferrin composed of egg
yolk phosphatidylcholine and phytosterol for oral delivery,
and examined any resulting anti-inflammatory effects. Oral
pretreatment of liposomal lactoferrin exhibited more
suppressive effects than did non-liposomal lactoferrin on
CCl4-induced hepatic injury in rats as well as on
lipopolysaccharide-induced TNF-alpha production from mouse
peripheral blood mononuclear leukocytes. Further investigation
revealed that the liposomalization did not exert influence on
the absorbability of lactoferrin to the venous blood or lymph
following an intraduodenal administration in rats.
Furthermore, there was no significant difference exhibited
between the antigenicity of liposomal and non-liposomal
lactoferrin, which was measured using the passive cutaneous
anaphylaxis reaction following oral sensitization to them in
guinea pigs. These results suggest that liposomal lactoferrin
might act more effectively than conventional lactoferrin in
the intestinal site, which is regarded as an active site of
orally administered lactoferrin, although the biological
mechanism is not fully understood yet. Consequently we propose
that liposomal lactoferrin could be a novel active constituent
useful for preventive and therapeutic treatment of
inflammatory diseases.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking