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Ironjustic
Wed, Nov-02-05, 06:16
Asian Pac J Allergy Immunol. 2005 Jun-Sep;23(2-3):121-6.
Related Articles, Links

Restrictive lung disease and serum TGF-beta1 in thalassemia
major children.

Sritippayawan S, Lekhanont P, Harnruthakorn C,
Samransamruajkit R, Deerojanawong J, Seksarn P, Poovorawan Y,
Prapphal N.

Division of Pulmonology and Critical Care Medicine, King
Chulalongkorn Memorial Hospital, Department of Pediatrics,
Faculty of Medicine, Chulalongkorn University, Bangkok,
Thailand. suchadacu@hotmail.com

A cross sectional study was performed in 21 thalassemia major
(TM) children at King Chulalongkorn Memorial Hospital during
March to August, 2003 to determine whether restrictive lung
disease (RLD) was related to serum transforming growth
factor-beta 1 (TGF-beta1). All studied patients (57% female,
age 11.2 +/- 2.6 yrs, duration of transfusion 7.7 +/- 4.1 yrs)
never had desferoxamine treatment and their pulmonary
function, serum ferritin and serum TGF-beta1 were evaluated.
Five (24%) had RLD. RLD patients had significantly longer
durations of transfusion and higher serum ferritin levels than
non-RLD patients (9.1 +/- 1.9 vs 5.5 +/- 3.2 yrs; p = 0.03 and
3,816.6 +/- 1,715.9 vs 2,084.5 +/- 1,504.8 ng/ml; p = 0.04,
respectively). TM children had lower serum TGF-beta1 levels
than normal children (7.9 vs
78.8 pg/ml; p < 0.001). The serum TGF-beta1 level was not
different between RLD and non-RLD patients (13.3 vs 4.2
pg/ml; ns), concluding that RLD was related to longer
duration of transfusion and higher serum ferritin but not
related to serum TGF-beta1 levels.

PMID: 16252842 [PubMed - in process]

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Who loves ya. Tom

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outsor
Wed, Nov-02-05, 17:16
"RLD was related to longer duration of transfusion and higher
serum ferritin "

So, what about transfusions made the level of this disorder
higher and caused higher iron levels to follow?
Ironjustic
Thu, Nov-03-05, 17:16
Now .. put down your mindset of puke .. and pickup your
mindset of medical cop ..

Transfusions are NOTORIOUS for raising iron levels in the body
.. raising .. ferritin levels ..

This is due to the increased iron from the red blood cells
that die and are replaced by transfusions ..

So in this one would use what you might call ..
'circumstantial evidence' .. that .. the ferritin rise is DUE
TO .. the iron from the transfusions ..

So .. when compared to OTHER studies .. the increased iron is
ALSO found in asthma .. which IS / has been SHOWN to BE ..
'related' .. to .. RLD ..

Soooooooo ..

More evidence ..

Tis all ..

And you seem to have a problem with it ..

You seem to have some sort of .. agenda ..

Heh .. heh ..

>>
what about transfusions made the level of this disorder higher
and caused higher iron levels to follow<<

Answer your own question ..

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking