Ironjustic
Sun, Oct-30-05, 17:16
Br J Nutr. 2005 May;93(5):655-62. Related Articles, Links
The effects of vitamin E supplementation on autoimmune-prone
New Zealand black x New Zealand white F1 mice fed an
oxidised oil diet.
Hsieh CC, Lin BF.
Laboratory of Nutritional Chemistry, Institute of Microbiology
and Biochemistry, College of Life Science, National Taiwan
University, Taipei, Taiwan 10764, Republic of China.
The purpose of the present study was to investigate the effect
of vitamin E supplementation on autoimmune disease in New
Zealand blackxNew Zealand white F1 (NZB/W F1) female mice fed
an oxidised oil diet. First, 5-month-old mice were fed an
AIN-76 diet containing either 150 g fresh soyabean oil/kg
(15S), 50 g fresh soyabean oil/kg + 100 g oxidised frying
oil/kg (5S10F) or 5S10F supplemented with
all-rac-alpha-tocopheryl acetate at 275 mg/kg diet level
(5S10F5E) or 550 mg/kg (5S10F10E), respectively, in experiment
1. The results showed that mice fed the 5S10F10E diet had a
lower anti-double-stranded DNA IgG antibody level and a longer
lifespan than those fed the 15S and 5S10F diets. Therefore,
the 5S10F and 5S10F10E treatments were repeated in experiment
2 for further analysis. The results showed that vitamin E
supplementation in the oxidised oil significantly decreased
thiobarbituric acid-reactive substance values in the kidney
and spleen of NZB/W F1 mice. Interferon-gamma and IL-6
production by mitogen-stimulated splenocytes decreased in mice
fed the 5S10F10E diet, whereas the secretion of IL-2 and IL-10
was not affected. The percentage of T-cells was significantly
higher and that of MHC class II-bearing cells was lower in the
spleens of the 5S10F10E group. The 5S10F10E group had a
significantly higher linoleic acid (18 : 2n-6) composition
than the 5S10F diet group. Therefore, vitamin E
supplementation in oxidised oil might decrease oxidative
stress, anti-double-stranded DNA IgG antibody, regulate
cytokines and lymphocyte subsets, and subsequently alleviate
the severity of autoimmune disease such as systemic lupus
erythematosus under oxidative stress.
PMID: 15975164 [PubMed - indexed for MEDLINE]
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Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
The effects of vitamin E supplementation on autoimmune-prone
New Zealand black x New Zealand white F1 mice fed an
oxidised oil diet.
Hsieh CC, Lin BF.
Laboratory of Nutritional Chemistry, Institute of Microbiology
and Biochemistry, College of Life Science, National Taiwan
University, Taipei, Taiwan 10764, Republic of China.
The purpose of the present study was to investigate the effect
of vitamin E supplementation on autoimmune disease in New
Zealand blackxNew Zealand white F1 (NZB/W F1) female mice fed
an oxidised oil diet. First, 5-month-old mice were fed an
AIN-76 diet containing either 150 g fresh soyabean oil/kg
(15S), 50 g fresh soyabean oil/kg + 100 g oxidised frying
oil/kg (5S10F) or 5S10F supplemented with
all-rac-alpha-tocopheryl acetate at 275 mg/kg diet level
(5S10F5E) or 550 mg/kg (5S10F10E), respectively, in experiment
1. The results showed that mice fed the 5S10F10E diet had a
lower anti-double-stranded DNA IgG antibody level and a longer
lifespan than those fed the 15S and 5S10F diets. Therefore,
the 5S10F and 5S10F10E treatments were repeated in experiment
2 for further analysis. The results showed that vitamin E
supplementation in the oxidised oil significantly decreased
thiobarbituric acid-reactive substance values in the kidney
and spleen of NZB/W F1 mice. Interferon-gamma and IL-6
production by mitogen-stimulated splenocytes decreased in mice
fed the 5S10F10E diet, whereas the secretion of IL-2 and IL-10
was not affected. The percentage of T-cells was significantly
higher and that of MHC class II-bearing cells was lower in the
spleens of the 5S10F10E group. The 5S10F10E group had a
significantly higher linoleic acid (18 : 2n-6) composition
than the 5S10F diet group. Therefore, vitamin E
supplementation in oxidised oil might decrease oxidative
stress, anti-double-stranded DNA IgG antibody, regulate
cytokines and lymphocyte subsets, and subsequently alleviate
the severity of autoimmune disease such as systemic lupus
erythematosus under oxidative stress.
PMID: 15975164 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------
-------------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking