C.Health
Wed, Sep-28-05, 06:49
http://news.yahoo.com/s/nm/20050927/hl_nm/pomegranate_cancer_-
dc
Pomegranate juice promising for prostate cancer By Karla Gale
Pomegranate extract may prevent prostate cancer or slow
its growth, if results of lab experiments conducted at
the University of Wisconsin in Madison translate to
real-world benefits.
Dr. Hasan Mukhtar and his colleagues note in the Proceedings
of the National Academy of Sciences Early Edition that
pomegranates are high in polyphenolic compounds, making
its juice higher in antioxidant activity than red wine and
green tea.
When they incubated prostate cancer cells with low
concentrations of pomegranate extract, they observed a
dose-related inhibition of cell growth.
In prostate cancer cells driven by male hormones (androgens)
and expressing prostate specific antigen (PSA), treatment with
pomegranate extract decreased androgen receptors and PSA
expression.
When human prostate cancer cells were injected into mice,
feeding the animals pomegranate extract delayed the appearance
of tumors. Tumor growth was significantly inhibited and
survival was prolonged.
As for whether pomegranate juice could be recommended to men
with prostate cancer, Mukhtar told Reuters Health: "Based on
the data we have it's highly unlikely that it will produce any
adverse effects and it is highly possible that it will produce
useful effects."
Moreover, he added, since his group has also shown that
pomegranate extract inhibits skin cancer growth, it is
possible that the juice would be of benefit in many types
of cancer.
SOURCE: Proceedings of the National Academy of Sciences, Early
Edition September 26, 2005.
dc
Pomegranate juice promising for prostate cancer By Karla Gale
Pomegranate extract may prevent prostate cancer or slow
its growth, if results of lab experiments conducted at
the University of Wisconsin in Madison translate to
real-world benefits.
Dr. Hasan Mukhtar and his colleagues note in the Proceedings
of the National Academy of Sciences Early Edition that
pomegranates are high in polyphenolic compounds, making
its juice higher in antioxidant activity than red wine and
green tea.
When they incubated prostate cancer cells with low
concentrations of pomegranate extract, they observed a
dose-related inhibition of cell growth.
In prostate cancer cells driven by male hormones (androgens)
and expressing prostate specific antigen (PSA), treatment with
pomegranate extract decreased androgen receptors and PSA
expression.
When human prostate cancer cells were injected into mice,
feeding the animals pomegranate extract delayed the appearance
of tumors. Tumor growth was significantly inhibited and
survival was prolonged.
As for whether pomegranate juice could be recommended to men
with prostate cancer, Mukhtar told Reuters Health: "Based on
the data we have it's highly unlikely that it will produce any
adverse effects and it is highly possible that it will produce
useful effects."
Moreover, he added, since his group has also shown that
pomegranate extract inhibits skin cancer growth, it is
possible that the juice would be of benefit in many types
of cancer.
SOURCE: Proceedings of the National Academy of Sciences, Early
Edition September 26, 2005.