Ironjustic
Tue, Aug-23-05, 17:43
They find genetic iron mutations COMMON in those with
gestational diabetes .. AND .. find iron is ALWAYS .. higher
..
<<snip>> serum ferritin levels were increased in patients with
GDM compared to healthy pregnant controls <<snip>>
Fetal Diagn Ther. 2005 Sep-Oct;20(5):349-54. Related
Articles, Links
Increased C282Y Heterozygosity in Gestational Diabetes.
Cauza E, Hanusch-Enserer U, Bischof M, Spak M, Kostner K,
Tammaa A, Dunky A, Ferenci P.
Department of Internal Medicine V, Department of
Diabetes, Metabolism and Rheumatology, Wilhelminenspital,
Vienna, Austria.
Background: Hereditary hemochromatosis is an autosomal
recessive disorder of iron metabolism that is characterized by
excess accumulation of iron in various organs and often leads
to diabetes mellitus (DM). To study whether mutations in the
hemochromatosis gene (HFE) could be a risk factor for the
development of gestational diabetes mellitus (GDM), the
prevalence of HFE mutations in patients with GDM was compared
to that of healthy pregnant controls. Methods: GDM was
diagnosed in 208 of 2,421 pregnant woman screened between the
24th and 28thweek of gestation over a period of 18 months.
Patients and 170 matched control subjects were screened for
the HFE gene mutations C282Y and H63D. Results: In North and
Central European GDM patients, the allele frequency of the
C282Y mutation (7.7%) was higher than in pregnant controls
(2.9%; p = 0.04), while the frequency of the H63D mutation was
not different (p = 0.45). Three patients with GDM were
homozygous for H63D (3.1%), 1 patient was homozygous for C282Y
(1.0%), 2 patients were compound heterozygous (2.0%) and 26
were heterozygous [11 C282Y (11.2%) and 15 H63D (15.3%)].
C282Y and H63D allele frequencies were not different between
controls and GDM patients of Southern European or non-European
origin. Irrespective of the HFE-mutation status, serum
ferritin levels were increased in patients with GDM compared
to healthy pregnant controls (p = 0.01), while transferrin
saturation was similar in both groups. Conclusions: In North
and Central European patients with GDM, the C282Y allele
frequency is higher than in healthy pregnant women, suggesting
a genetic susceptibility to the development of GDM. Copyright
(c) 2005 S. Karger AG, Basel.
PMID: 16113552 [PubMed - in process]
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Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
gestational diabetes .. AND .. find iron is ALWAYS .. higher
..
<<snip>> serum ferritin levels were increased in patients with
GDM compared to healthy pregnant controls <<snip>>
Fetal Diagn Ther. 2005 Sep-Oct;20(5):349-54. Related
Articles, Links
Increased C282Y Heterozygosity in Gestational Diabetes.
Cauza E, Hanusch-Enserer U, Bischof M, Spak M, Kostner K,
Tammaa A, Dunky A, Ferenci P.
Department of Internal Medicine V, Department of
Diabetes, Metabolism and Rheumatology, Wilhelminenspital,
Vienna, Austria.
Background: Hereditary hemochromatosis is an autosomal
recessive disorder of iron metabolism that is characterized by
excess accumulation of iron in various organs and often leads
to diabetes mellitus (DM). To study whether mutations in the
hemochromatosis gene (HFE) could be a risk factor for the
development of gestational diabetes mellitus (GDM), the
prevalence of HFE mutations in patients with GDM was compared
to that of healthy pregnant controls. Methods: GDM was
diagnosed in 208 of 2,421 pregnant woman screened between the
24th and 28thweek of gestation over a period of 18 months.
Patients and 170 matched control subjects were screened for
the HFE gene mutations C282Y and H63D. Results: In North and
Central European GDM patients, the allele frequency of the
C282Y mutation (7.7%) was higher than in pregnant controls
(2.9%; p = 0.04), while the frequency of the H63D mutation was
not different (p = 0.45). Three patients with GDM were
homozygous for H63D (3.1%), 1 patient was homozygous for C282Y
(1.0%), 2 patients were compound heterozygous (2.0%) and 26
were heterozygous [11 C282Y (11.2%) and 15 H63D (15.3%)].
C282Y and H63D allele frequencies were not different between
controls and GDM patients of Southern European or non-European
origin. Irrespective of the HFE-mutation status, serum
ferritin levels were increased in patients with GDM compared
to healthy pregnant controls (p = 0.01), while transferrin
saturation was similar in both groups. Conclusions: In North
and Central European patients with GDM, the C282Y allele
frequency is higher than in healthy pregnant women, suggesting
a genetic susceptibility to the development of GDM. Copyright
(c) 2005 S. Karger AG, Basel.
PMID: 16113552 [PubMed - in process]
--------------------------------------------------------------
-------------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking