Ironjustic
Sat, Jul-09-05, 16:21
'Those' .. in the seat of power .. medical health
professionals .. have now ramped UP the RDA for iron . In
light of recent discoveries .. they have effectively .. signed
a death warrant for .. many .. ?
Wouldn't this article state .. contrary .. to INCREASED iron
in our food supply .. the reduction OF .. iron .. might be
more .. productive .. ?
Especially in light of the upcoming .. epidemics of .. avian
flu .. and the .. like .. ?
<<snip>> The management of dietary iron can therefore be
influential in aiding the outcome of this disease. <<snip>>
Tuberculosis (Edinb). 2004;84(1-2):110-30. Related
Articles, Links
Iron, mycobacteria and tuberculosis.
Ratledge C.
Department of Biological Sciences, University of Hull, Hull
HU6 7RX, UK. c.ratle...@biosci.hull.ac.uk
The role of iron in the growth and metabolism of M.
tuberculosis and other mycobacteria is discussed in relation
to the acquisiton of iron from host sources, such as
transferrin, lactoferrin and ferritin, and its subsequent
assimilation and utilization by the bacteria. Key components
involved in the acquisition of iron (as ferric ion) and its
initial transport into the mycobacterial cell are
extracellular iron binding agents (siderophores) which, in
pathogenic mycobacteria, are the carboxymycobactins and, in
saprophytic mycobacteria, are the exochelins. In both cases,
iron may be transferred to an intra-envelope, short-term
storage molecule, mycobactin. For transport across the cell
membrane, a reductase is used which converts FeIII-mycobactin
to the FeII form. The ferrous ion, possibly complexed with
salicylic acid, is then shuttled across the membrane either
for direct incorporation into various porphyrins and
apoproteins or, for storage of iron within the bacterial
cytoplasm, bacterioferritin. The overall process of iron
acquisition and its utilization is under very genetic tight
control. The importance of iron in the virulence of
mycobacteria is discussed in relationship to the development
of tuberculosis. The management of dietary iron can therefore
be influential in aiding the outcome of this disease. The role
of the old anti-TB compound, p-aminosalicylate (PAS), is
discussed in its action as an inhibitor of iron assimilation,
together with the prospects of being able to synthesize
further selective inhibitors of iron metabolism that may be
useful as future chemotherapeutic agents.
Publication Types: Review Review, Tutorial
PMID: 14670352
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
professionals .. have now ramped UP the RDA for iron . In
light of recent discoveries .. they have effectively .. signed
a death warrant for .. many .. ?
Wouldn't this article state .. contrary .. to INCREASED iron
in our food supply .. the reduction OF .. iron .. might be
more .. productive .. ?
Especially in light of the upcoming .. epidemics of .. avian
flu .. and the .. like .. ?
<<snip>> The management of dietary iron can therefore be
influential in aiding the outcome of this disease. <<snip>>
Tuberculosis (Edinb). 2004;84(1-2):110-30. Related
Articles, Links
Iron, mycobacteria and tuberculosis.
Ratledge C.
Department of Biological Sciences, University of Hull, Hull
HU6 7RX, UK. c.ratle...@biosci.hull.ac.uk
The role of iron in the growth and metabolism of M.
tuberculosis and other mycobacteria is discussed in relation
to the acquisiton of iron from host sources, such as
transferrin, lactoferrin and ferritin, and its subsequent
assimilation and utilization by the bacteria. Key components
involved in the acquisition of iron (as ferric ion) and its
initial transport into the mycobacterial cell are
extracellular iron binding agents (siderophores) which, in
pathogenic mycobacteria, are the carboxymycobactins and, in
saprophytic mycobacteria, are the exochelins. In both cases,
iron may be transferred to an intra-envelope, short-term
storage molecule, mycobactin. For transport across the cell
membrane, a reductase is used which converts FeIII-mycobactin
to the FeII form. The ferrous ion, possibly complexed with
salicylic acid, is then shuttled across the membrane either
for direct incorporation into various porphyrins and
apoproteins or, for storage of iron within the bacterial
cytoplasm, bacterioferritin. The overall process of iron
acquisition and its utilization is under very genetic tight
control. The importance of iron in the virulence of
mycobacteria is discussed in relationship to the development
of tuberculosis. The management of dietary iron can therefore
be influential in aiding the outcome of this disease. The role
of the old anti-TB compound, p-aminosalicylate (PAS), is
discussed in its action as an inhibitor of iron assimilation,
together with the prospects of being able to synthesize
further selective inhibitors of iron metabolism that may be
useful as future chemotherapeutic agents.
Publication Types: Review Review, Tutorial
PMID: 14670352
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking