Ironjustic
Sat, Jul-09-05, 17:21
This would give some credence to the theory sickle cell is an
iron overload disease .. from .. BIRTH .. and the iron
overload destroys tocopherol .. and BOTH .. problems MUST be
addressed AT .. birth.
<<snip>> Conclusion: This study shows that short-term
supplementation with alpha-tocopherol may be beneficial to the
paediatric sickle cell sufferer. <<snip>>
Niger Postgrad Med J. 2005 Jun;12(2):110-4. Related
Articles, Links
Changes in Erythrocytes following Supplementation with
alpha-Tocopherol in Children Suffering from Sickle Cell
Anaemia.
Jaja SI, Aigbe PE, Gbenebitse S, Temiye EO.
Department of Physiology, College of Medicine,
University of Lagos,
P.M.B. 12003, Lagos. Nigeria.
Introduction: Low plasma vitamin E level in children with
sickle cell anaemia has been related to elevated level of
irreversibly sickled cells which has been implicated in the
pathogenesis of painful crisis. In adult patients
supplementation with alpha-tocopherol has been shown to reduce
irreversibly sickled cell count. In-addition, vitamin E
supplementation increases resting forearm blood flow and
reduces forearm vascular resistance in adult sickle cell
anaemia sufferers. Aim: The aim of the study was to examine
the effects of supplementation with alpha-tocopherol on
arterial blood pressure, some haematological parameters and
osmotic fragility in children suffering from sickle cell
anaemia. Methodology: The effects of supplementation with
alpha-tocopherol (100 mg. per day for 6 weeks) on packed cell
volume (PCV) haemoglobin concentration ([Hb]), mean
corpuscular haemoglobin concentration (MCHC), per cent foetal
haemoglobin (% HbF), per cent irreversibly sickled cells (%
ISC), erythrocyte osmotic fragility and blood pressure have
been assessed in ten (10) children suffering from sickle cell
anaemia. Their ages ranged from 4.0 to 10.0 years. Results:
Supplementation with alpha-tocopherol significantly increased
packed cell volume (p< 0.001), haemoglobin concentration (p<
0.01) and per cent foetal haemoglobin (p< 0.001), but
significantly reduced mean corpuscular haemoglobin
concentration (p< 0.01) and per cent irreversibly sickled
cells (p< 0.001). alpha-Tocopherol also increased the
resistance of the cells to lysis. Supplementation with
alpha-tocopherol had little or no effect on arterial blood
pressure Conclusion: This study shows that short-term
supplementation with alpha-tocopherol may be beneficial to the
paediatric sickle cell sufferer. . Keywords: sickle cell
anaemia, erythrocytes, alpha-tocopherol..
PMID: 15997260 [PubMed - in process]
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Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
iron overload disease .. from .. BIRTH .. and the iron
overload destroys tocopherol .. and BOTH .. problems MUST be
addressed AT .. birth.
<<snip>> Conclusion: This study shows that short-term
supplementation with alpha-tocopherol may be beneficial to the
paediatric sickle cell sufferer. <<snip>>
Niger Postgrad Med J. 2005 Jun;12(2):110-4. Related
Articles, Links
Changes in Erythrocytes following Supplementation with
alpha-Tocopherol in Children Suffering from Sickle Cell
Anaemia.
Jaja SI, Aigbe PE, Gbenebitse S, Temiye EO.
Department of Physiology, College of Medicine,
University of Lagos,
P.M.B. 12003, Lagos. Nigeria.
Introduction: Low plasma vitamin E level in children with
sickle cell anaemia has been related to elevated level of
irreversibly sickled cells which has been implicated in the
pathogenesis of painful crisis. In adult patients
supplementation with alpha-tocopherol has been shown to reduce
irreversibly sickled cell count. In-addition, vitamin E
supplementation increases resting forearm blood flow and
reduces forearm vascular resistance in adult sickle cell
anaemia sufferers. Aim: The aim of the study was to examine
the effects of supplementation with alpha-tocopherol on
arterial blood pressure, some haematological parameters and
osmotic fragility in children suffering from sickle cell
anaemia. Methodology: The effects of supplementation with
alpha-tocopherol (100 mg. per day for 6 weeks) on packed cell
volume (PCV) haemoglobin concentration ([Hb]), mean
corpuscular haemoglobin concentration (MCHC), per cent foetal
haemoglobin (% HbF), per cent irreversibly sickled cells (%
ISC), erythrocyte osmotic fragility and blood pressure have
been assessed in ten (10) children suffering from sickle cell
anaemia. Their ages ranged from 4.0 to 10.0 years. Results:
Supplementation with alpha-tocopherol significantly increased
packed cell volume (p< 0.001), haemoglobin concentration (p<
0.01) and per cent foetal haemoglobin (p< 0.001), but
significantly reduced mean corpuscular haemoglobin
concentration (p< 0.01) and per cent irreversibly sickled
cells (p< 0.001). alpha-Tocopherol also increased the
resistance of the cells to lysis. Supplementation with
alpha-tocopherol had little or no effect on arterial blood
pressure Conclusion: This study shows that short-term
supplementation with alpha-tocopherol may be beneficial to the
paediatric sickle cell sufferer. . Keywords: sickle cell
anaemia, erythrocytes, alpha-tocopherol..
PMID: 15997260 [PubMed - in process]
--------------------------------------------------------------
-------------------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking