Ironjustic
Tue, Jul-05-05, 17:27
<<snip>> We hypothesize that locally increased concentrations
of iron induce accumulation of exogenous and endogenous Abeta
in SMCs, triggering beta-amyloid angiopathy. <<snip>>
Neurobiol Aging. 2005 Jun 30; [Epub ahead of print] Related
Articles, Links
Induction of vascular amyloidosis-beta by oxidative stress
depends on APOE genotype.
Mazur-Kolecka B, Dickson D, Frackowiak J.
New York State Institute for Basic Research in Developmental
Disabilities, Department of Developmental Neurobiology, 1050
Forest Hill Road, Staten Island, NY 10314, USA.
The reduced antioxidant defense in apolipoprotein E
varepsilon4/varepsilon4 carriers may contribute to
beta-amyloidosis. Previously we found that Fe(2+)-induced
oxidative stress caused greater protein oxidation in
varepsilon4/varepsilon4 than in varepsilon3/varepsilon3 human
brain vascular smooth muscle cells. Moreover, Fe(2+) induced
lysosomal accumulation of endogenous Abeta and APOE in
cultured cells, and Abeta deposition in vascular tunica media
in organotypic cultures of brain vessels. Here we demonstrated
that Fe(2+) enhanced an uptake of exogenous Abeta 1-40 and its
deposition together with APOE in lysosomes in myocytes. Abeta
deposits were associated with lipid-peroxidation and protein
ubiquitination, and were more abundant and stable in
varepsilon4/varepsilon4 than in varepsilon3/varepsilon3 cells.
In organotypic cultures of brain vessels Fe(2+) induced
deposition of non-fibrillar and fibrillar Abeta 1-40 in
vascular tunica media. We hypothesize that locally increased
concentrations of iron induce accumulation of exogenous and
endogenous Abeta in SMCs, triggering beta-amyloid angiopathy.
The greater susceptibility of varepsilon4 carriers to Fe(2+)
ions may result in an increased risk of beta-amyloidosis.
PMID: 15993987 [PubMed - as supplied by publisher]
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Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man
Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
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of iron induce accumulation of exogenous and endogenous Abeta
in SMCs, triggering beta-amyloid angiopathy. <<snip>>
Neurobiol Aging. 2005 Jun 30; [Epub ahead of print] Related
Articles, Links
Induction of vascular amyloidosis-beta by oxidative stress
depends on APOE genotype.
Mazur-Kolecka B, Dickson D, Frackowiak J.
New York State Institute for Basic Research in Developmental
Disabilities, Department of Developmental Neurobiology, 1050
Forest Hill Road, Staten Island, NY 10314, USA.
The reduced antioxidant defense in apolipoprotein E
varepsilon4/varepsilon4 carriers may contribute to
beta-amyloidosis. Previously we found that Fe(2+)-induced
oxidative stress caused greater protein oxidation in
varepsilon4/varepsilon4 than in varepsilon3/varepsilon3 human
brain vascular smooth muscle cells. Moreover, Fe(2+) induced
lysosomal accumulation of endogenous Abeta and APOE in
cultured cells, and Abeta deposition in vascular tunica media
in organotypic cultures of brain vessels. Here we demonstrated
that Fe(2+) enhanced an uptake of exogenous Abeta 1-40 and its
deposition together with APOE in lysosomes in myocytes. Abeta
deposits were associated with lipid-peroxidation and protein
ubiquitination, and were more abundant and stable in
varepsilon4/varepsilon4 than in varepsilon3/varepsilon3 cells.
In organotypic cultures of brain vessels Fe(2+) induced
deposition of non-fibrillar and fibrillar Abeta 1-40 in
vascular tunica media. We hypothesize that locally increased
concentrations of iron induce accumulation of exogenous and
endogenous Abeta in SMCs, triggering beta-amyloid angiopathy.
The greater susceptibility of varepsilon4 carriers to Fe(2+)
ions may result in an increased risk of beta-amyloidosis.
PMID: 15993987 [PubMed - as supplied by publisher]
--------------------------------------------------------------
-------------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man
Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking