The Fat Connection To Beta Cell Burnout

[dina1957]

I've got this newsletter today. Wonder what do u guys think about it. I wonder if it's excess body fat or circulating FFAs as well:q: Never a dull moment.

Besides insulin, fat can also cause beta cell burnout. One out of 12 people in the western world suffers from type 2 (adult onset) diabetes. Worldwide, 150 million people are diabetic and their numbers are expected to double in the next 20 years, a result of the growing obesity epidemic. Yet, the reasons for the strong correlation between excess body fat and diabetes have been puzzling researchers. Scientists at the Weizmann Institute of Science and the University of Umea, Sweden, have now unraveled a mechanism by which fat contributes to the onset of the disease.
The rest of the article can be found at http://www.diabetesincontrol.com/modules.php?name=News&file=article&sid=2771

[Squid]

I'm no expert, but here's what I see in this article....


"Elevated fat in the bloodstream appears to accelerate both stages of the disease; but exactly how does this happen?"

I've read this other places. The thing that *may* be an assumption is that a high fat diet (ie presumably low carb) contributes to excess fat in the bloodstream. It may in fact be just the opposite.

"But when fat is present in addition to sugar, the GPR40 receptor causes even greater insulin output."

This tells me not to eat crap at McDonalds. It definitely says fat in addition to sugar. It does not say fat alone. It does not say if this is a meal containing these foods or if the body already has high fat and high blood sugars which would essentially be diabetes and the damage to the beta cells would already be present.

This article doesn't convince me to give up my high fat diet. However, there are studies that say that a high fat consumption is linked to diabetes. The question in my mind is if they are high fat/high carb or high fat/low carb.

Lisa

[dina1957]

This is my question too. If this is high carb/high fat insulin connection or like I've read already, it's fat or FFA in bloodstream that make it harder for insulin to do it's job, making us even more IR:q: