N-acetylcysteine / colitis

[Ironjustic]

J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related
Articles, Links

Effects of N-acetylcysteine treatment on oxidative stress in
acetic acid-induced experimental colitis in rats.

Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M, Aydin
HH.

Department of General Surgery, Ege University School of
Medicine, Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr

We assessed the possible protective effects of
N-acetylcysteine (NAC) against toxic damage in the rat colon.
Two doses of NAC (20 mg/kg and 100 mg/kg) given for 2 days and
7 days after acetic acid administration (to induce colitis)
were tested. NAC was dissolved in saline and administered
locally (intracolonic), systemically (intraperitoneal) or in a
combination (intracolonic and intraperitoneal). Several
parameters, including macroscopic and histopathological scores
and myeloperoxidase, glutathione and nitric oxide
concentrations were measured using standard assay procedures.
Treatment with 100 mg/kg NAC for 7 days significantly
decreased tissue myeloperoxidase, glutathione and nitric oxide
concentrations. The 20 mg/kg dose had no protective effects.
The data indicate that NAC substantially reduced the degree of
colonic injury, probably by regulating free radical production
and inhibiting inflammation. It may, therefore, have a role in
the treatment of inflammatory bowel disease.

PMID: 15790131 [PubMed - in process]

--------------------------------------------------------------
-------------------

Who loves ya. Tom

Jesus Was A Vegetarian! http://herbivore.7h.com

[Ken.W]

IT'S BEEN A PART OF MY NUTRIONAL REGIMEN FOR YEARS.
<ironjustice@aol.com> wrote in message
news:1111954901.926211.288620@g14g2000cwa.googlegroups.com...
>J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related
>Articles, Links
>
>
> Effects of N-acetylcysteine treatment on oxidative stress in
> acetic acid-induced experimental colitis in rats.
>
> Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M,
> Aydin HH.
>
> Department of General Surgery, Ege University School of
> Medicine, Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr
>
> We assessed the possible protective effects of
> N-acetylcysteine (NAC) against toxic damage in the rat
> colon. Two doses of NAC (20 mg/kg and 100 mg/kg) given for 2
> days and 7 days after acetic acid administration (to induce
> colitis) were tested. NAC was dissolved in saline and
> administered locally (intracolonic), systemically
> (intraperitoneal) or in a combination (intracolonic and
> intraperitoneal). Several parameters, including macroscopic
> and histopathological scores and myeloperoxidase,
> glutathione and nitric oxide concentrations were measured
> using standard assay procedures. Treatment with 100 mg/kg
> NAC for 7 days significantly decreased tissue
> myeloperoxidase, glutathione and nitric oxide
> concentrations. The 20 mg/kg dose had no protective effects.
> The data indicate that NAC substantially reduced the degree
> of colonic injury, probably by regulating free radical
> production and inhibiting inflammation. It may, therefore,
> have a role in the treatment of inflammatory bowel disease.
>
> PMID: 15790131 [PubMed - in process]
>
> ------------------------------------------------------------
> ---------------------
>
> Who loves ya. Tom
>
> Jesus Was A Vegetarian! http://herbivore.7h.com

[John H]

This is the first time I have heard of it, but I notice a lot
of supplement makers sell it on their web sites. I don't
recall it at the Chemist shop.I searched the UC Berkely site
and nothing came up. John <ironjustice@aol.com> wrote in
message
news:1111954901.926211.288620@g14g2000cwa.googlegroups.com...
>J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related
>Articles, Links
>
>
> Effects of N-acetylcysteine treatment on oxidative stress in
> acetic acid-induced experimental colitis in rats.
>
> Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M,
> Aydin HH.
>
> Department of General Surgery, Ege University School of
> Medicine, Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr
>
> We assessed the possible protective effects of
> N-acetylcysteine (NAC) against toxic damage in the rat
> colon. Two doses of NAC (20 mg/kg and 100 mg/kg) given for 2
> days and 7 days after acetic acid administration (to induce
> colitis) were tested. NAC was dissolved in saline and
> administered locally (intracolonic), systemically
> (intraperitoneal) or in a combination (intracolonic and
> intraperitoneal). Several parameters, including macroscopic
> and histopathological scores and myeloperoxidase,
> glutathione and nitric oxide concentrations were measured
> using standard assay procedures. Treatment with 100 mg/kg
> NAC for 7 days significantly decreased tissue
> myeloperoxidase, glutathione and nitric oxide
> concentrations. The 20 mg/kg dose had no protective effects.
> The data indicate that NAC substantially reduced the degree
> of colonic injury, probably by regulating free radical
> production and inhibiting inflammation. It may, therefore,
> have a role in the treatment of inflammatory bowel disease.
>
> PMID: 15790131 [PubMed - in process]
>
> ------------------------------------------------------------
> ---------------------
>
> Who loves ya. Tom
>
> Jesus Was A Vegetarian! http://herbivore.7h.com

[Ken.W]

Thats not surprising that berkely doesn't have anything on
it.I bet they don't have anything on olive oil extract either.
I've copied and paste a bit of info on it for you John. If you
had read the Book "the comparitive guide to nutritonal
supplements" you will find that it was a key element in any
worthwhile supplement according to the nutritional experts he
based his comparison too.

a.. N-acetyl-L-cysteine has been used in the treatment of
acetaminophen overdose, chronic lung disorders; HIV (where
it has been shown to enhance human T-cell function and
survival), and hepatitis B (where is has been shown to
inhibit hepatitis B replication). It has been further used
as a chemopreventative agent in cancer research.
b..
c.. 1 Lehninger AL. Biochemistry. Worth Publishers, Inc., New
York. 1104 pp. 1975. 2 Rivlin RS. Riboflavin. Pp. 167-173.
In. EE Ziegler and LJ Filer (eds.) Present Knowledge in
Nutrition. ILSI Press, Washington, DC. 3 Lavender OA and RF
Burk. Selenium. Pp. 320-328. In. EE Ziegler and LJ Filer
(eds.) Present Knowledge in Nutrition. ILSI Press,
Washington, DC. 4 Lomaestro BM and M Malone. Glutathione in
health and disease: pharmacotherapeutic issues. Annals of
Pharmacotherapy (1995) 29: 1263-73 5 Aw TY, Wierzbicka G,
Jones DP. Oral glutathione increases tissue glutathione in
vivo. Chem Biol Interact 1991;80:89-97. 6 Smilkstein MJ,
Knapp GL, Kulig KW, Rumack BH. Efficacy of oral
N-acetylcysteine in the treatment of acetaminophen overdose.
Analysis of the national multicenter studyN Engl J Med Dec
15 1988; 319(24):1557-62. 7 Cayota A, Vuillier F, Gonzalez
G, Dighiero G. In vitro antioxidant treatment recovers
proliferative responses of anergic CD4+ lymphocytes from
human immunodeficiency virus-infected individuals. Blood
1996 Jun 1;
87(11):4746-53. 8 Weiss L, Hildt E, Hofschneider PH.
Anti-hepatitis B virus activity of N-acetyl-L-cysteine
(NAC): new aspects of a well-established drug.
Antiviral Res 1996 Aug;32(1):43-53. 9 Ho YS; Lee HM;
Mou TC; Wang YJ; Lin JK . Suppression of nitric
oxide-induced apoptosis by N-acetyl-L-cysteine through
modulation of glutathione, bcl-2, and bax protein
levels. Mol Carcinog1997 Jun;
87(12):101-13. 10 Jones DP, Coates RJ, Flagg EW, Eley JW,
Block G, Greenberg RS, et al. Glutathione in foods
listed in the National Cancer Institutes health habits
and history food frequency questionnaire. Nutr Cancer
1992;17:57-75. 11 Kaplowitz N, AW TY, Ookhtens M. The
regulation of hepatic glutathione. Ann Rev Pharmacol
Toxicol 1985;25:715-44.

a..
b..
c..
d.. "John H" <john@rhubarb.org> wrote in message
news:4247d0ee@clear.net.nz...
> This is the first time I have heard of it, but I notice a
> lot of supplement makers sell it on their web sites. I don't
> recall it at the Chemist shop.I searched the UC Berkely site
> and nothing came up. John <ironjustice@aol.com> wrote in
> message news:1111954901.926211.288620@g14g2000cwa.googlegro-
> ups.com...
>>J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related
>>Articles, Links
>>
>>
>> Effects of N-acetylcysteine treatment on oxidative stress
>> in acetic acid-induced experimental colitis in rats.
>>
>> Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M,
>> Aydin HH.
>>
>> Department of General Surgery, Ege University School of
>> Medicine, Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr
>>
>> We assessed the possible protective effects of
>> N-acetylcysteine (NAC) against toxic damage in the rat
>> colon. Two doses of NAC (20 mg/kg and 100 mg/kg) given for
>> 2 days and 7 days after acetic acid administration (to
>> induce colitis) were tested. NAC was dissolved in saline
>> and administered locally (intracolonic), systemically
>> (intraperitoneal) or in a combination (intracolonic and
>> intraperitoneal). Several parameters, including macroscopic
>> and histopathological scores and myeloperoxidase,
>> glutathione and nitric oxide concentrations were measured
>> using standard assay procedures. Treatment with 100 mg/kg
>> NAC for 7 days significantly decreased tissue
>> myeloperoxidase, glutathione and nitric oxide
>> concentrations. The 20 mg/kg dose had no protective
>> effects. The data indicate that NAC substantially reduced
>> the degree of colonic injury, probably by regulating free
>> radical production and inhibiting inflammation. It may,
>> therefore, have a role in the treatment of inflammatory
>> bowel disease.
>>
>> PMID: 15790131 [PubMed - in process]
>>
>> -----------------------------------------------------------
>> ----------------------
>>
>> Who loves ya. Tom
>>
>> Jesus Was A Vegetarian! http://herbivore.7h.com
>

[John H]

They ( Berkeley University) would tke a conservative approach.
When I said they didn't have any info on it I meant the search
engine function on their site (which is new) didn't come up
with anything. the Comparative Guide to Nutritional
Supplements is part of Usana's marketing strategy
http://www.melaleuca.com/wc/pdf/ComparativeGuide.pdf Your
"Nutrient Regimen" is something off the Ray Strand website? He
reccomends Usana (and vice versa) John "Ken.W"
<phosgate@telus.net> wrote in message
news:PhW1e.84124$KI2.80595@clgrps12...
> Thats not surprising that berkely doesn't have anything on
> it.I bet they don't have anything on olive oil extract
> either. I've copied and paste a bit of info on it for you
> John. If you had read the Book "the comparitive guide to
> nutritonal supplements" you will find that it was a key
> element in any worthwhile supplement according to the
> nutritional experts he based his comparison too.
>
> a.. N-acetyl-L-cysteine has been used in the treatment of
> acetaminophen overdose, chronic lung disorders; HIV (where
> it has been shown to enhance human T-cell function and
> survival), and hepatitis B (where is has been shown to
> inhibit hepatitis B replication). It has been further used
> as a chemopreventative agent in cancer research.
> a..
> a.. 1 Lehninger AL. Biochemistry. Worth Publishers, Inc.,
> New York. 1104 pp. 1975. 2 Rivlin RS. Riboflavin. Pp.
> 167-173. In. EE Ziegler and LJ Filer (eds.) Present
> Knowledge in Nutrition. ILSI Press, Washington, DC. 3
> Lavender OA and RF Burk. Selenium. Pp. 320-328. In. EE
> Ziegler and LJ Filer (eds.) Present Knowledge in
> Nutrition. ILSI Press, Washington, DC. 4 Lomaestro BM and
> M Malone. Glutathione in health and disease:
> pharmacotherapeutic issues. Annals of Pharmacotherapy
> (1995) 29: 1263-73 5 Aw TY, Wierzbicka G, Jones DP. Oral
> glutathione increases tissue glutathione in vivo. Chem
> Biol Interact 1991;80:89-97. 6 Smilkstein MJ, Knapp GL,
> Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in
> the treatment of acetaminophen overdose. Analysis of the
> national multicenter studyN Engl J Med Dec 15 1988;
> 319(24):1557-62. 7 Cayota A, Vuillier F, Gonzalez G,
> Dighiero G. In vitro antioxidant treatment recovers
> proliferative responses of anergic CD4+ lymphocytes from
> human immunodeficiency virus-infected individuals. Blood
> 1996 Jun 1;
> 87(11):4746-53. 8 Weiss L, Hildt E, Hofschneider PH.
> Anti-hepatitis B virus activity of
> N-acetyl-L-cysteine (NAC): new aspects of a
> well-established drug. Antiviral Res 1996
> Aug;32(1):43-53. 9 Ho YS; Lee HM; Mou TC; Wang YJ;
> Lin JK . Suppression of nitric oxide-induced
> apoptosis by N-acetyl-L-cysteine through modulation
> of glutathione, bcl-2, and bax protein levels. Mol
> Carcinog1997 Jun;
> 19(2):101-13. 10 Jones DP, Coates RJ, Flagg EW, Eley JW,
> Block G, Greenberg RS, et al. Glutathione in foods
> listed in the National Cancer Institutes health
> habits and history food frequency questionnaire. Nutr
> Cancer 1992;17:57-75. 11 Kaplowitz N, AW TY, Ookhtens
> M. The regulation of hepatic glutathione. Ann Rev
> Pharmacol Toxicol 1985;25:715-44.
>
> a..
> a..
> a..
> a.. "John H" <john@rhubarb.org> wrote in message
> news:4247d0ee@clear.net.nz...
>> This is the first time I have heard of it, but I notice a
>> lot of supplement makers sell it on their web sites. I
>> don't recall it at the Chemist shop.I searched the UC
>> Berkely site and nothing came up. John
>> <ironjustice@aol.com> wrote in message news:1111954901.926-
>> 211.288620@g14g2000cwa.googlegroups.com...
>>>J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related
>>>Articles, Links
>>>
>>>
>>> Effects of N-acetylcysteine treatment on oxidative stress
>>> in acetic acid-induced experimental colitis in rats.
>>>
>>> Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M,
>>> Aydin HH.
>>>
>>> Department of General Surgery, Ege University School of
>>> Medicine, Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr
>>>
>>> We assessed the possible protective effects of
>>> N-acetylcysteine (NAC) against toxic damage in the rat
>>> colon. Two doses of NAC (20 mg/kg and 100 mg/kg) given for
>>> 2 days and 7 days after acetic acid administration (to
>>> induce colitis) were tested. NAC was dissolved in saline
>>> and administered locally (intracolonic), systemically
>>> (intraperitoneal) or in a combination (intracolonic and
>>> intraperitoneal). Several parameters, including
>>> macroscopic and histopathological scores and
>>> myeloperoxidase, glutathione and nitric oxide
>>> concentrations were measured using standard assay
>>> procedures. Treatment with 100 mg/kg NAC for 7 days
>>> significantly decreased tissue myeloperoxidase,
>>> glutathione and nitric oxide concentrations. The 20 mg/kg
>>> dose had no protective effects. The data indicate that NAC
>>> substantially reduced the degree of colonic injury,
>>> probably by regulating free radical production and
>>> inhibiting inflammation. It may, therefore, have a role in
>>> the treatment of inflammatory bowel disease.
>>>
>>> PMID: 15790131 [PubMed - in process]
>>>
>>> ----------------------------------------------------------
>>> -----------------------
>>>
>>> Who loves ya. Tom
>>>
>>> Jesus Was A Vegetarian! http://herbivore.7h.com
>>>
>>
>

[Ken.W]

uh no it's not john.....you keep referring to it's second
edition...why is that? Can you not find anything wrong with
the third edition...does it suit even you and is that what
bugs you about it? Just like Mr. Mcwilliam said...he did an
awesome job in editiing the second edition...(Lord knows why
he would have spent the time and effor tto do so) But with
getting back to the present all his arguements have
disappeared with the third edition of " The comparitive guide
to nutritonal supplements" has it not?? But if you do have any
legitimate complaints about the third edition...tell us about
it. Or is your only complaint that USANA got top billing
again? If so..tell us whats wrong with it..

"John H" <john@rhubarb.org> wrote in message
news:42485a02@clear.net.nz...
> They ( Berkeley University) would tke a conservative
> approach. When I said they didn't have any info on it I
> meant the search engine function on their site (which is
> new) didn't come up with anything. the Comparative Guide to
> Nutritional Supplements is part of Usana's marketing
> strategy
> http://www.melaleuca.com/wc/pdf/ComparativeGuide.pdf Your
> "Nutrient Regimen" is something off the Ray Strand website?
> He reccomends Usana (and vice versa) John "Ken.W"
> <phosgate@telus.net> wrote in message
> news:PhW1e.84124$KI2.80595@clgrps12...
>> Thats not surprising that berkely doesn't have anything on
>> it.I bet they don't have anything on olive oil extract
>> either. I've copied and paste a bit of info on it for you
>> John. If you had read the Book "the comparitive guide to
>> nutritonal supplements" you will find that it was a key
>> element in any worthwhile supplement according to the
>> nutritional experts he based his comparison too.
>>
>> a.. N-acetyl-L-cysteine has been used in the treatment of
>> acetaminophen overdose, chronic lung disorders; HIV
>> (where it has been shown to enhance human T-cell function
>> and survival), and hepatitis B (where is has been shown
>> to inhibit hepatitis B replication). It has been further
>> used as a chemopreventative agent in cancer research.
>> a..
>> a.. 1 Lehninger AL. Biochemistry. Worth Publishers, Inc.,
>> New York. 1104 pp. 1975. 2 Rivlin RS. Riboflavin. Pp.
>> 167-173. In. EE Ziegler and LJ Filer (eds.) Present
>> Knowledge in Nutrition. ILSI Press, Washington, DC. 3
>> Lavender OA and RF Burk. Selenium. Pp. 320-328. In. EE
>> Ziegler and LJ Filer (eds.) Present Knowledge in
>> Nutrition. ILSI Press, Washington, DC. 4 Lomaestro BM and
>> M Malone. Glutathione in health and disease:
>> pharmacotherapeutic issues. Annals of Pharmacotherapy
>> (1995) 29: 1263-73 5 Aw TY, Wierzbicka G, Jones DP. Oral
>> glutathione increases tissue glutathione in vivo. Chem
>> Biol Interact 1991;80:89-97. 6 Smilkstein MJ, Knapp GL,
>> Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in
>> the treatment of acetaminophen overdose. Analysis of the
>> national multicenter studyN Engl J Med Dec 15 1988;
>> 319(24):1557-62. 7 Cayota A, Vuillier F, Gonzalez G,
>> Dighiero G. In vitro antioxidant treatment recovers
>> proliferative responses of anergic CD4+ lymphocytes from
>> human immunodeficiency virus-infected individuals. Blood
>> 1996 Jun 1;
>> 87(11):4746-53. 8 Weiss L, Hildt E, Hofschneider PH.
>> Anti-hepatitis B virus activity of
>> N-acetyl-L-cysteine (NAC): new aspects of a
>> well-established drug. Antiviral Res 1996
>> Aug;32(1):43-53. 9 Ho YS; Lee HM; Mou TC; Wang YJ;
>> Lin JK . Suppression of nitric oxide-induced
>> apoptosis by N-acetyl-L-cysteine through modulation
>> of glutathione, bcl-2, and bax protein levels. Mol
>> Carcinog1997 Jun;
>> 19(2):101-13. 10 Jones DP, Coates RJ, Flagg EW, Eley JW,
>> Block G, Greenberg RS, et al. Glutathione in foods
>> listed in the National Cancer Institutes health
>> habits and history food frequency questionnaire.
>> Nutr Cancer 1992;17:57-75. 11 Kaplowitz N, AW TY,
>> Ookhtens M. The regulation of hepatic glutathione.
>> Ann Rev Pharmacol Toxicol 1985;25:715-44.
>>
>> a..
>> a..
>> a..
>> a.. "John H" <john@rhubarb.org> wrote in message
>> news:4247d0ee@clear.net.nz...
>>> This is the first time I have heard of it, but I notice a
>>> lot of supplement makers sell it on their web sites. I
>>> don't recall it at the Chemist shop.I searched the UC
>>> Berkely site and nothing came up. John
>>> <ironjustice@aol.com> wrote in message news:1111954901.92-
>>> 6211.288620@g14g2000cwa.googlegroups.com...
>>>>J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related
>>>>Articles, Links
>>>>
>>>>
>>>> Effects of N-acetylcysteine treatment on oxidative stress
>>>> in acetic acid-induced experimental colitis in rats.
>>>>
>>>> Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M,
>>>> Aydin HH.
>>>>
>>>> Department of General Surgery, Ege University School of
>>>> Medicine, Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr
>>>>
>>>> We assessed the possible protective effects of
>>>> N-acetylcysteine (NAC) against toxic damage in the rat
>>>> colon. Two doses of NAC (20 mg/kg and 100 mg/kg) given
>>>> for 2 days and 7 days after acetic acid administration
>>>> (to induce colitis) were tested. NAC was dissolved in
>>>> saline and administered locally (intracolonic),
>>>> systemically (intraperitoneal) or in a combination
>>>> (intracolonic and intraperitoneal). Several parameters,
>>>> including macroscopic and histopathological scores and
>>>> myeloperoxidase, glutathione and nitric oxide
>>>> concentrations were measured using standard assay
>>>> procedures. Treatment with 100 mg/kg NAC for 7 days
>>>> significantly decreased tissue myeloperoxidase,
>>>> glutathione and nitric oxide concentrations. The 20 mg/kg
>>>> dose had no protective effects. The data indicate that
>>>> NAC substantially reduced the degree of colonic injury,
>>>> probably by regulating free radical production and
>>>> inhibiting inflammation. It may, therefore, have a role
>>>> in the treatment of inflammatory bowel disease.
>>>>
>>>> PMID: 15790131 [PubMed - in process]
>>>>
>>>> ---------------------------------------------------------
>>>> ------------------------
>>>>
>>>> Who loves ya. Tom
>>>>
>>>> Jesus Was A Vegetarian! http://herbivore.7h.com
>>>>
>>>
>>>
>>
>

[John H]

That reply is worth responding to. John "Ken.W"
<phosgate@telus.net> wrote in message
news:z7Z1e.124798$fc4.34237@edtnps89...
> uh no it's not john.....you keep referring to it's second
> edition...why is that? Can you not find anything wrong with
> the third edition...does it
suit
> even you and is that what bugs you about it? Just like Mr.
> Mcwilliam said...he did an awesome job in editiing the
> second edition...(Lord knows why he would have spent the
> time and effor tto do so) But with getting
back
> to the present all his arguements have disappeared with the
> third edition
of
> " The comparitive guide to nutritonal supplements" has it
> not?? But if
you
> do have any legitimate complaints about the third
> edition...tell us about
> it. Or is your only complaint that USANA got top billing
> again? If so..tell us whats wrong with it..
>
>
> "John H" <john@rhubarb.org> wrote in message
> news:42485a02@clear.net.nz...
> > They ( Berkeley University) would tke a conservative
> > approach. When I
said
> > they didn't have any info on it I meant the search engine
> > function on their site (which is new) didn't come up with
> > anything. the Comparative Guide to Nutritional Supplements
> > is part of Usana's marketing strategy
> > http://www.melaleuca.com/wc/pdf/ComparativeGuide.pdf Your
> > "Nutrient Regimen" is something off the Ray Strand
> > website? He reccomends Usana (and vice versa) John "Ken.W"
> > <phosgate@telus.net> wrote in message
> > news:PhW1e.84124$KI2.80595@clgrps12...
> >> Thats not surprising that berkely doesn't have anything
> >> on it.I bet
they
> >> don't have anything on olive oil extract either. I've
> >> copied and paste
a
> >> bit of info on it for you John. If you had read the Book
> >> "the comparitive guide to nutritonal supplements" you
> >> will find that it was a key element in any worthwhile
> >> supplement according to the nutritional experts he based
> >> his comparison too.
> >>
> >> a.. N-acetyl-L-cysteine has been used in the treatment of
acetaminophen
> >> overdose, chronic lung disorders; HIV (where it has been
> >> shown to
enhance
> >> human T-cell function and survival), and hepatitis B
> >> (where is has been shown to inhibit hepatitis B
> >> replication). It has been further used as
a
> >> chemopreventative agent in cancer research.
> >> a..
> >> a.. 1 Lehninger AL. Biochemistry. Worth Publishers, Inc.,
> >> New York.
1104
> >> pp. 1975. 2 Rivlin RS. Riboflavin. Pp. 167-173. In. EE
> >> Ziegler and LJ Filer
(eds.)
> >> Present Knowledge in Nutrition. ILSI Press, Washington,
> >> DC. 3 Lavender OA and RF Burk. Selenium. Pp. 320-328. In.
> >> EE Ziegler and LJ Filer (eds.) Present Knowledge in
> >> Nutrition. ILSI Press, Washington,
DC.
> >> 4 Lomaestro BM and M Malone. Glutathione in health and
> >> disease: pharmacotherapeutic issues. Annals of
> >> Pharmacotherapy (1995) 29:
1263-73
> >> 5 Aw TY, Wierzbicka G, Jones DP. Oral glutathione
> >> increases tissue glutathione in vivo. Chem Biol Interact
> >> 1991;80:89-97. 6 Smilkstein MJ, Knapp GL, Kulig KW,
> >> Rumack BH. Efficacy of oral N-acetylcysteine in the
> >> treatment of acetaminophen overdose. Analysis
of
> >> the national multicenter studyN Engl J Med Dec 15 1988;
319(24):1557-62.
> >> 7 Cayota A, Vuillier F, Gonzalez G, Dighiero G. In vitro
> >> antioxidant treatment recovers proliferative responses of
> >> anergic CD4+ lymphocytes from human immunodeficiency
> >> virus-infected individuals. Blood 1996 Jun
1;
> >> 87(11):4746-53. 8 Weiss L, Hildt E, Hofschneider PH.
> >> Anti-hepatitis B virus activity of
> >> N-acetyl-L-cysteine (NAC): new aspects of a
> >> well-established drug. Antiviral Res 1996
> >> Aug;32(1):43-53. 9 Ho YS; Lee HM; Mou TC; Wang YJ;
> >> Lin JK . Suppression of nitric oxide-induced
> >> apoptosis by N-acetyl-L-cysteine through
> >> modulation of glutathione, bcl-2, and bax protein
> >> levels. Mol Carcinog1997 Jun;
> >> 19(2):101-13. 10 Jones DP, Coates RJ, Flagg EW, Eley JW,
> >> Block G, Greenberg RS, et
al.
> >> Glutathione in foods listed in the National Cancer
> >> Institutes health habits and history food frequency
> >> questionnaire. Nutr Cancer 1992;17:57-75. 11 Kaplowitz N,
> >> AW TY, Ookhtens M. The regulation of hepatic
glutathione.
> >> Ann Rev Pharmacol Toxicol 1985;25:715-44.
> >>
> >> a..
> >> a..
> >> a..
> >> a.. "John H" <john@rhubarb.org> wrote in message
> >> news:4247d0ee@clear.net.nz...
> >>> This is the first time I have heard of it, but I notice
> >>> a lot of supplement makers sell it on their web sites. I
> >>> don't recall it at the Chemist shop.I searched the UC
> >>> Berkely site and nothing came up. John
> >>> <ironjustice@aol.com> wrote in message news:1111954901.-
> >>> 926211.288620@g14g2000cwa.googlegroups.com...
> >>>>J Int Med Res. 2005 Mar-Apr;33(2):196-206. Related
> >>>>Articles, Links
> >>>>
> >>>>
> >>>> Effects of N-acetylcysteine treatment on oxidative
> >>>> stress in acetic acid-induced experimental colitis in
> >>>> rats.
> >>>>
> >>>> Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek
> >>>> M, Aydin HH.
> >>>>
> >>>> Department of General Surgery, Ege University School of
> >>>> Medicine, Bornova, Izmir, Turkey. eakgun@med.ege.edu.tr
> >>>>
> >>>> We assessed the possible protective effects of
> >>>> N-acetylcysteine (NAC) against toxic damage in the rat
> >>>> colon. Two doses of NAC (20 mg/kg and 100 mg/kg) given
> >>>> for 2 days and 7 days after acetic acid
administration
> >>>> (to induce colitis) were tested. NAC was dissolved in
> >>>> saline and administered locally (intracolonic),
> >>>> systemically (intraperitoneal)
or
> >>>> in a combination (intracolonic and intraperitoneal).
> >>>> Several parameters, including macroscopic and
> >>>> histopathological scores and myeloperoxidase,
> >>>> glutathione and nitric oxide concentrations were
> >>>> measured using standard assay procedures. Treatment
> >>>> with 100 mg/kg
NAC
> >>>> for 7 days significantly decreased tissue
> >>>> myeloperoxidase,
glutathione
> >>>> and nitric oxide concentrations. The 20 mg/kg dose had
> >>>> no protective effects. The data indicate that NAC
> >>>> substantially reduced the degree
of
> >>>> colonic injury, probably by regulating free radical
> >>>> production and inhibiting inflammation. It may,
> >>>> therefore, have a role in the treatment of inflammatory
> >>>> bowel disease.
> >>>>
> >>>> PMID: 15790131 [PubMed - in process]
> >>>>
>
>>>> ---------------------------------------------------------
>>>> ---------------
---------
> >>>>
> >>>> Who loves ya. Tom
> >>>>
> >>>> Jesus Was A Vegetarian! http://herbivore.7h.com
> >>>>
> >>>
> >>>
> >>
> >>
> >
>

[John H]

That reply is not worth responding to "John H"
<JohnH@nospam.no.nz> wrote in message
news:424871e1@clear.net.nz...
> That reply is worth responding to.

[Ken.W]

thats par for the course with you John...you get asked what
all your whining is about and you refuse to answer any of
it... :) "John H" <JohnH@nospam.no.nz> wrote in message
news:42487488@clear.net.nz...
> That reply is not worth responding to "John H"
> <JohnH@nospam.no.nz> wrote in message
> news:424871e1@clear.net.nz...
>> That reply is worth responding to.

[nonavailab]

Ken.W wrote:
> you keep referring to it's second edition...why is that? Can
> you not find anything wrong with the third edition...

The third edition still has the following flaws:

1. In every edition, 1st, 2nd, AND 3rd, the "experts" who made
the recommendations are primarily businessmen who operate
supplement companies. Not a single one of the "experts"
holds an academic position in the nutrition field, plus has
NO financial ties to the supplement industry. Not a single
"expert," Ken.

2. NONE of the editions, 1st, 2nd, or 3rd, cites scientific
studies comparing actual people taking one brand of
vitamins against actual people taking anther brand. Nowhere
does the book give data demonstrating that people on the
vitamin rated #1 are in any way healthier than people on
vitamin #20: no comparisons of actual people's longevity,
incidence of disease, incidence of disability, days of work
lost to illness, etc., etc.

3. The author of the book asked the "experts" (businessmen) to
recommend the best amounts of each vitamin, and then he
took those recommendations and AVERAGED THEM OUT! And it
gets worse: He then declares that these averages are the
"best" amounts of vitamins to take.

This is completely junk science.

No medical or scientific papers have ever been published
proposing that the "best" dose of a drug or a vitamin or a
mineral is the average of seven different opinions. This is
never, never, never done. It's a joke.

4. The author of the book has openly (on the Web) admitted
that he is, just like Ken, a salesman for USTANKA.

[nonavailab]

> Or is your only complaint that USANA got top billing again?

Tell us the name of just one scientist or physician with NO
financial ties to the supplement industry who gives USTANKA
"top billing."

[Mortimer S]

John H wrote:
> That reply is not worth responding to "John H"
> <JohnH@nospam.no.nz> wrote in message
> news:424871e1@clear.net.nz...
>> That reply is worth responding to.

More crossposted crap.

[John H]

As the links writer demonstrates "the Comparative Guide to
Nutritional Supplements " is nothing more than a marketing
ploy for the U$ana Essentials". I doubt that it has changed
with the 3rd edition. I don't doubt that Usana make high
quality supplements ( although they claim 'superior'), but I
don't think the major non mlm companies would lay themselves
open by being substandard either. As Berkley University says:
" A multi need not cost more than a few cents a day. You
don't need a fancy multi. Most store-brand and generic
products are fine."
http://wellnessletter.com/html/ds/dsMultivitamins.php John

"Ken.W" <phosgate@telus.net> wrote in message
news:9D_1e.125838$fc4.52131@edtnps89...
> thats par for the course with you John...you get asked what
> all your
whining
> is about and you refuse to answer any of it... :) "John H"
> <JohnH@nospam.no.nz> wrote in message
news:42487488@clear.net.nz...
> > That reply is not worth responding to "John H"
> > <JohnH@nospam.no.nz> wrote in message
> > news:424871e1@clear.net.nz...
> >> That reply is worth responding to.
> >
>

[Philemon]

It might be more useful to explain that N-acetylcysteine can
be purchased as things with names like Mucosolvon, and
traditionally is used to unblock catarrh and congestion in
colds. Its benefic effect comes from its ability to increase
permeability of mucous membrane and hence fluidifies mucous
secretion (yuck!) You can also buy it as acetylcysteine in
Holland and Barrett. Oh, and BTW, it's the best cure for a
hangover too, since it increases liver function (hence the
action against acetaminophen poisining) and especially of
alcohol dehydrogenase (according to New Scientist magazine).

[John Que]

"Mortimer Schnerd, RN" <mortschnerd@carolina.rr.com.remove>
wrote in message
news:6G12e.73116$wl4.2191255@twister.southeast.rr.com...
> John H wrote:
> > That reply is not worth responding to "John H"
> > <JohnH@nospam.no.nz> wrote in message
news:424871e1@clear.net.nz...
> >> That reply is worth responding to.
>
>
> More crossposted crap.

Ah yes "crap" part of the nursing process ;-)