Ironjustic
Sun, Mar-27-05, 17:15
Asian Pac J Cancer Prev. 2005 Jan-Mar;6(1):41-7. Related
Articles, Links
Dietary Administration of Inositol and/or Inositol-6-phosphate
Prevents Chemically-induced Rat Hepatocarcinogenesis.
Lee HJ, Lee SA, Choi H.
Department of Food and Nutrition, Seoul National University,
Seoul 151-742, Korea. choihm@snu.ac.kr.
Chemoprevention is considered a rational strategy for dietary
approaches to prevention of cancer. Multiple lines of evidence
suggest that many of our dietary principles are able to
intervene in the multistage carcinogenesis process and phytic
acid (inositol hexaphosphate, IP6), a phytochemical present in
a variety of plant species, has been shown to prevent various
cancers, including those of the mammary gland, colon and
liver. However, the mechanism of chemoprevention by IP6 has
not been fully elucidated. In the present study, we examined
the effects of inositol and/or IP6 supplementation on rat
hepatocarcinogenesis initiated by diethylnitrosamine (DEN) and
promoted by partial hepatectomy (PH). Supplementation with
either inositol or IP6, or their combination, starting one
week prior to administration of DEN, resulted in a significant
decrease in both the area and the number of placental
glutathione S-transferase positive (GST-P+) foci, a
preneoplastic marker for DEN-initiated hepatocarcinogenesis.
The administration of inositol and/or IP6 in drinking water
caused marked enhancement in the glutathione S-transferase
(GST) activity. In addition, the production of thiobarbituric
acid reactive substances and the catalase activity were
significantly reduced in rats supplemented with inositol and
/or IP6. Based on these findings, it is likely that the
chemopreventive effects of inositol and/or IP6 on rat
hepatocarcinogenesis initiated by DEN and promoted by PH are
associated with induction of GST activity and suppression of
lipid peroxidation.
PMID: 15780031 [PubMed - in process]
--------------------------------------------------------------
-------------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://herbivore.7h.com
Articles, Links
Dietary Administration of Inositol and/or Inositol-6-phosphate
Prevents Chemically-induced Rat Hepatocarcinogenesis.
Lee HJ, Lee SA, Choi H.
Department of Food and Nutrition, Seoul National University,
Seoul 151-742, Korea. choihm@snu.ac.kr.
Chemoprevention is considered a rational strategy for dietary
approaches to prevention of cancer. Multiple lines of evidence
suggest that many of our dietary principles are able to
intervene in the multistage carcinogenesis process and phytic
acid (inositol hexaphosphate, IP6), a phytochemical present in
a variety of plant species, has been shown to prevent various
cancers, including those of the mammary gland, colon and
liver. However, the mechanism of chemoprevention by IP6 has
not been fully elucidated. In the present study, we examined
the effects of inositol and/or IP6 supplementation on rat
hepatocarcinogenesis initiated by diethylnitrosamine (DEN) and
promoted by partial hepatectomy (PH). Supplementation with
either inositol or IP6, or their combination, starting one
week prior to administration of DEN, resulted in a significant
decrease in both the area and the number of placental
glutathione S-transferase positive (GST-P+) foci, a
preneoplastic marker for DEN-initiated hepatocarcinogenesis.
The administration of inositol and/or IP6 in drinking water
caused marked enhancement in the glutathione S-transferase
(GST) activity. In addition, the production of thiobarbituric
acid reactive substances and the catalase activity were
significantly reduced in rats supplemented with inositol and
/or IP6. Based on these findings, it is likely that the
chemopreventive effects of inositol and/or IP6 on rat
hepatocarcinogenesis initiated by DEN and promoted by PH are
associated with induction of GST activity and suppression of
lipid peroxidation.
PMID: 15780031 [PubMed - in process]
--------------------------------------------------------------
-------------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://herbivore.7h.com