Ironjustic
Sun, Mar-27-05, 17:15
Free Radic Res. 2005 Mar;39(3):337-42. Related Articles, Links
The association between serum ferritin and uric acid in
humans.
Ghio AJ, Ford ES, Kennedy TP, Hoidal JR.
National Health and Environmental Effects Research Laboratory
Office of Research and Development, Environmental Protection
Agency Research Triangle Park, NC 27711 USA.
Objective: Urate forms a coordination complex with Fe(3+)
which does not support electron transport. The only enzymatic
source of urate is xanthine oxidoreductase. If a major purpose
of xanthine oxidoreductase is the production of urate to
function as an iron chelator and antioxidant, a system for
coupling the activity of this enzyme to the availability of
catalytically-active metal would be required. We tested the
hypothesis that there is an association between iron
availability and urate production in healthy humans by
correlating serum concentrations of ferritin with uric acid
levels. Materials and methods: The study population included
4932 females and 4794 males in the National Health and
Nutrition Examination Survey III. They were 20 years of age or
older and in good health. Results: Serum concentrations of
ferritin correlated positively with uric acid levels in
healthy individuals. This association was independent of an
effect of gender, age, race/ethnic group, body mass, and
alcohol consumption. Conclusions: The relationship between
serum ferritin and uric acid predicts hyperuricemia and gout
in groups with iron accumulation. This elevation in the
production of uric acid with increased concentrations of iron
could possibly reflect a response of the host to diminish the
oxidative stress presented by available metal as the uric acid
assumes the empty or loosely bound coordination sites of the
iron to diminish electron transport and subsequent oxidant
generation.
PMID: 15788238 [PubMed - in process]
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Who loves ya. Tom
Jesus Was A Vegetarian! http://herbivore.7h.com
The association between serum ferritin and uric acid in
humans.
Ghio AJ, Ford ES, Kennedy TP, Hoidal JR.
National Health and Environmental Effects Research Laboratory
Office of Research and Development, Environmental Protection
Agency Research Triangle Park, NC 27711 USA.
Objective: Urate forms a coordination complex with Fe(3+)
which does not support electron transport. The only enzymatic
source of urate is xanthine oxidoreductase. If a major purpose
of xanthine oxidoreductase is the production of urate to
function as an iron chelator and antioxidant, a system for
coupling the activity of this enzyme to the availability of
catalytically-active metal would be required. We tested the
hypothesis that there is an association between iron
availability and urate production in healthy humans by
correlating serum concentrations of ferritin with uric acid
levels. Materials and methods: The study population included
4932 females and 4794 males in the National Health and
Nutrition Examination Survey III. They were 20 years of age or
older and in good health. Results: Serum concentrations of
ferritin correlated positively with uric acid levels in
healthy individuals. This association was independent of an
effect of gender, age, race/ethnic group, body mass, and
alcohol consumption. Conclusions: The relationship between
serum ferritin and uric acid predicts hyperuricemia and gout
in groups with iron accumulation. This elevation in the
production of uric acid with increased concentrations of iron
could possibly reflect a response of the host to diminish the
oxidative stress presented by available metal as the uric acid
assumes the empty or loosely bound coordination sites of the
iron to diminish electron transport and subsequent oxidant
generation.
PMID: 15788238 [PubMed - in process]
--------------------------------------------------------------
-------------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://herbivore.7h.com