hyperthyroidism / rust / oxidative stress

[Ironjustic]

Mediators Inflamm. 2005 Feb;2005(1):57-9. Related
Articles, Links

Levels of malondialdehyde and superoxide dismutase in
subclinical hyperthyroidism.

Cetinkaya A, Kurutas EB, Buyukbese MA, Kantarceken B,
Bulbuloglu E.

We aimed to determine whether patients with subclinical
hyperthyroidism (SH) are subject to oxidative stress.
Twenty-two women and 8 men having endogenous subclinical
hyperthyroidism for a duration of at least 6 months, and 21
women and 9 men healthy controls were included in this study.
We measured the level of plasma malondialdehyde, as one of the
lipid peroxidation markers, and the activity of erythrocyte
superoxide dismutase, which is an antioxidant enzyme. The
activity of erythrocyte superoxide dismutase and plasma
malondialdehyde levels were found to be significantly higher
in subjects with subclinical hyperthyroidism than the control
group ( $P &<.01$ ). The results of this study suggest that
oxidative stress and antioxidative response could be increased
in patients having subclinical hyperthyroidism.

PMID: 15770068 [PubMed - in process]

--------------------------------------------------------------
-------------------

Who loves ya. Tom

http://herbivore.7h.com

[Montygram]

Physiologically, it's much more likely the other way around.
In other words, the oxidative stress suppresses the thyroid.
This is at least one of the major reasons for the "obesity
epidemic." Once the thyroid is suppressed (by oxidative
stress), metabolism slows, and you get fat. I eat as much
sugar, butter, coconut product, fruit, dark chocolate,
cheese, yogurt, etc. as I like, and yet at 40, I'm thin as a
rail, while my friends and family, who eat typical high
unsaturated fat and oxidized cholesterol diets, are either
overweight or obese. This is simple stuff, if you know a
little biochemistry and physiology. My book, which should be
out in less than a year, will explain all of this in the
simplest terms possible, so that anyone interested can
understand exactly what's going on.

i

[Laurie]

"montygram" <nazztrader@lycos.com> wrote in message
news:1111376821.048113.233620@o13g2000cwo.googlegroups.com...
> This is at least one of the major reasons for the "obesity
> epidemic."
http://www.ecologos.org/obese.htm

Laurie

[Robert]

"Laurie" <no@spam.com> wrote in message
news:423f0be4$1_3@alt.athenanews.com...
>
> "montygram" <nazztrader@lycos.com> wrote in message news:11-
> 11376821.048113.233620@o13g2000cwo.googlegroups.com...
> > This is at least one of the major reasons for the
> > "obesity epidemic."
> http://www.ecologos.org/obese.htm
>
> Laurie

What he is saying is that the cellular part for eating , the
local cultural diet, and psychological/emotional conditioning
center in the brain is damaged by oxidative stress. That fits
beautifully within his theory.

[Montygram]

What in the world are you trying to say here? I'll make it
clear: are you unaware of what suppresses the thyroid? And if
so, are you aware of the thyroid's role in metabolism? And if
so, are you aware of what happens when metabolism is slowed
significantly? You seem to be the most aggressively ignorant
person who has ever posted here. Go ahead and show us that
you are not.

[Robert]

"montygram" <nazztrader@lycos.com> wrote in message
news:1111461744.334165.159360@f14g2000cwb.googlegroups.com...
> What in the world are you trying to say here? I'll make it
> clear: are you unaware of what suppresses the thyroid? And
> if so, are you aware of the thyroid's role in metabolism?
> And if so, are you aware of what happens when metabolism is
> slowed significantly? You seem to be the most aggressively
> ignorant person who has ever posted here. Go ahead and show
> us that you are not.
>
Suppresses the thyroid? "We aimed to determine whether
patients with subclinical hyperthyroidism " Let me show you
my ignore here just a little bit about the thyroid.
Hyperthyroidism is an autoimmune disease involving antibody
damage to the organ. The antibody mimics the TSH that binds
to the TSH receptor and is known as a thyroid stimulating
immunoglobulin. The release of the thyroxin causes the
symptoms of hyperthyroidism and it is called graves disease.
In hypothyroidism the autoantibody causes damage to the
organ and not the receptor with an initial high release of
thyroxin with subsequent damage to the organ and diminishing
release of the hormone. In both diseases you see high levels
of microsomal antibodies and anti-thyroglobulin antibodies
which damage the organ. The end result is antibody induced
damage which terminates with like all cell death various
lipid degenerative changes. Fatty degradation of cells is
normal and common. Looking a damaged cells and looking for
oxidative stress is ?????? Why not look at red blood cells
that are coated with antibody and check for oxidative
stress? Give me a break

[Montygram]

Note to the last post:

I did not realize that Robert was talking about the link
posted by Laurie. I'm not sure what Robert was getting at, but
I thought he was commenting upon one of my posts. I'll
apologize for being harsh, but I thought he was being
sarcastic. I took a quick look at that web page Laurie posted,
and it has a bunch of abstracts on it. Some of them were
useful, others were not. In my upcoming book, I will explain
how an overall framework can be used to make sense of all the
abstracts, reports, and claims out there. In the meantime,
remember than a linoleic acid molecule is a linoleic acid
molecule, regardless of whether it came from an animal or a
plant. At the level of biochemistry, that is what matters. At
the nutritional science level, you get such molecules in your
body by eating a complex package of molecules, some of which
are unique to certain plants or animals, and some of which are
"generic," like linoleic acid. So, while linoleic acid (an
omega 6 fatty acid) is not something you want more than trace
amounts of in your diet, if it comes from lard, it has no
antioxdiant protection, whereas if it comes from good quality
nuts, it does. This is very important for maintaining health.

[Robert]

"montygram" <nazztrader@lycos.com> wrote in message
news:1111513474.354563.257600@z14g2000cwz.googlegroups.com...
> Note to the last post:

Cesk Fysiol. 2003 Feb;52(1):34-41. Related Articles, Links

[Lipid metabolism in atherogenesis]

[Article in Czech]

Bobkova D, Poledne R.

Laborator pro vyzkum aterosklerozy, Centrum experimentalniho
vyzkumu chorob srdce a cev, IKEM, Praha.

Lipoprotein (LP) metabolism plays a pivotal role in
atherogenesis. Breakdown of triglyceride (TG) rich
lipoproteins, both of exogenous--chylomicrones and
endogenous--very low density lipoproteiny (VLDL) produces
remnant lipoproteins after repeated action of lipoprotein
lipase (LPL). Atherogenity of remnant lipoprotein has been
proved. Also atheroprotective high density lipoproteins (HDL)
are produced from surface of TG rich lipoproteins during their
lipolysis. Protective role of HDL particles in atherogenesis
is manifested by reverse cholesterol transport from all
extrahepatic cells to the liver including cells of the
arterial wall. Plasma concentration of atherogenic low density
lipoproteins (LPL) is regulated by the production rate of VLDL
in the liver on the one hand and their utilization by
selective LDL receptors (mainly in the liver) on the other
hand. Number of functioning LDL receptors is regulated
genetically (gene for own LDL receptor and gene for both
ligands--apoprotein B and apoprotein E) and also by
environmental factors. Diet low in saturated fat and
cholesterol and rich in dietary fibres increases number of LDL
receptors and consequently decreases LDL cholesterol
concentration. Monocytes entering arterial wall when
intravasal and then subendothelial concentration of LDL is
increased absorb LDL and predominantly oxidized LDL by
scavenger receptors. During this repeated process they are
changed to macrophages, residual macrophages and foam cells.
Production of foam cells represents a starting point in
atherogenesis but their high presence is typical also for
advanced vulnerable atherosclerotic lesions, which are prone
to rupture producing clinical complication--myocardial
infarction and stroke.

PMID: 12693188 [PubMed - indexed for MEDLINE]

[Montygram]

In almost all cases of adult onset "diseases," excess
biochemical activity (usually in the form of AA metabolites)
causes dysfunction. The evidence is so overwhelming that it's
actually funny. Do some www.pubmed.com searches.

Here are a couple of recent ones:

Cell Biochem Funct. 2003 Dec;21(4):325-30.

Oxidative damage and antioxidant enzyme activities in
experimental hypothyroidism.

Yilmaz S, Ozan S, Benzer F, Canatan H.

Department of Biochemistry, College of Veterinary Medicine,
Firat (Euphrates) University, Elazig 23119, Turkey.
sevyilars@yahoo.com

Free radicals are now well known to damage cellular
components. To investigate whether age and thyroid level
affect peroxidation speed, we examined the levels of
malondialdehyde and antioxidant enzyme activities in different
age groups of hypothyroid rats. Hypothyroidism was induced in
30- and 60-day-old Wistar Albino rats by the i.p.
administration of propylthiouracil (10 mg kg(-1) body weight)
for 15 days. While malondialdehyde levels of 30- or 60-day-old
hypothyroid rats were increased in liver, they were decreased
in the tissues of the heart and thyroid. While
glucose-6-phosphate dehydrogenase activity levels did not
change in heart, brain and liver tissues of 30-day-old rats,
they increased in brain and heart tissues of 60-day-old
experimental groups, but decreased in the liver. Catalase
activities decreased in the liver and heart of rats with
hypothyroidism, but increased in erythrocytes. In control
groups while malondialdehyde levels increased in brain, heart
and thymus with regard to age, they decreased in plasma.
Glucose-6-phosphate dehydrogenase and catalase activities were
not affected by age in tissues of the thymus, thyroid and
brain, but they were decreased in the heart tissue. The
changes in the levels of lipid peroxidation and antioxidant
enzyme activities which were determined in different tissues
of hypothyroid rats indicate a cause for functional disorder
of these tissues. Moreover, there may be changes depending on
age at lipid peroxidation and antioxidant enzyme activity
levels. Copyright 2003 John Wiley & Sons, Ltd.

Indian J Exp Biol. 2003 Nov;41(11):1334-7.

Changes in lipid peroxidation and free radical scavengers in
kidney of hypothyroid and hyperthyroid rats.

Sawant BU, Nadkarni GD, Thakare UR, Joseph LJ, Rajan MG.

Laboratory Nuclear Medicine Section, Isotope Group, (BARC),
C/o Tata Memorial Centre Annexe, Parel, Mumbai 400 012, India.
bilvadaa@yahoo.com

Kidney weight was significantly decreased in hypothyroidism
(induced by Na131I administration) and increased in
hyperthyroidism (induced by thyroxine treatment) as compared
to control in female Wistar rats. The tissue lipid
peroxidation level remained unchanged in hyperthyroid rats but
significantly increased in hypothyroid rats. Superoxide
dismutase was decreased in both experimental groups but more
so in hyperthyroid rats. Catalase was reduced significantly in
hyperthyroid rats but remained unaffected in hypothyroid rats.
Tissue glutathione peroxidase (GPx) activity was increased
while reduced glutathione levels remained unaltered in both
hypothyroid and hyperthyroid rats. Plasma GPx activity was
significantly low in both the hypothyroid and hyperthyroid
rats. The results suggest alterations in the oxidative stress
in hypothyroid and hyperthyroid rat kidneys with concomitant
changes of free radical scavengers.

[Robert]

"montygram" <nazztrader@lycos.com> wrote in message
news:1111552001.311414.238650@o13g2000cwo.googlegroups.com...
> In almost all cases of adult onset "diseases," excess
> biochemical activity (usually in the form of AA metabolites)
> causes dysfunction. The evidence is so overwhelming that
> it's actually funny. Do some

Propylthiouracil is used to kill the thyroid in
hyperthyroidism and thyroxine is used to treat hypothyroidism.

What else are they suggesting for hyperthyroidism and
hypothyroidism?

Nothing? Thank you. Instead or rats maybe they can work their
way up to dogs in a few years.

[Montygram]

Laurie: exactly what is your claim? I'll take on all comers,
but you have to clearly articulate your ideas. If you are
having difficulty understanding a point I a making, you need
to explain exactly what the problem is.

Robert: Thank you for reiterating what MattLB and myself have
been posting here for a few years now (concerning oxidized
cholesterol). Otherwise, I don't know what you're getting at.
I'm not going to do the research for you. If I happen to come
across an abstract that appears to possibly satisfy you, I'll
post it. Otherwise, go ahead and subject your thryoid to all
the oxidative stress you wish.

[Laurie]

"montygram" <nazztrader@lycos.com> wrote in message
news:1111513474.354563.257600@z14g2000cwz.googlegroups.com...
> ..., remember than a linoleic acid molecule is a linoleic
> acid molecule, regardless of whether it came from an animal
> or a plant.
...
> So, while linoleic acid is not something you want more than
> trace amounts of in your diet, *if it comes from lard*, it
> has no antioxdiant protection, whereas if *it comes from
> good quality nuts*, it does.
Self contradiction; a sure method to upgrade one's
credibility.

Laurie

[Laurie]

"montygram" <nazztrader@lycos.com> wrote in message
news:1111513474.354563.257600@z14g2000cwz.googlegroups.com...
> I took a quick look at that web page Laurie posted, and it
> has a bunch of abstracts on it.
Why don't you take an -honest- look, and try refuting any
concept there with facts and logic, not insults?

Laurie

[Andrew Hee]

Thanks for this great thread, which has enabled me to identify
and block a bunch of crossposting idiots and trolls.

A

[Pizza Girl]

I don't think many of them are seeing your posts anymore. You
are posting your snips in vain.

"Andrew Heenan" <andrew@heenan73.wanadoo.co.uk> wrote in
message news:d23kd4$ba1$1@newsg2.svr.pol.co.uk...
> Thanks for this great thread, which has enabled me to
> identify and block a bunch of crossposting idiots and
> trolls.
>
> A

[John Riggs]

You too, eh?

"Andrew Heenan" <andrew@heenan73.wanadoo.co.uk> wrote in
message news:d23kd4$ba1$1@newsg2.svr.pol.co.uk...
| Thanks for this great thread, which has enabled me to
| identify and block a bunch of crossposting idiots and
| trolls.
|
| A
|
|

[Laurie]

"montygram" <nazztrader@lycos.com> wrote in message
news:1111617178.391124.191490@g14g2000cwa.googlegroups.com...
> Laurie: exactly what is your claim? I'll take on all comers,
> but you have to clearly articulate your ideas.

=====
repeat post:

"montygram" <nazztrader@lycos.com> wrote in message
news:1111513474.354563.257600@z14g2000cwz.googlegroups.com...
> ..., remember than a linoleic acid molecule is a linoleic
> acid molecule, regardless of whether it came from an animal
> or a plant.
...
> So, while linoleic acid is not something you want more than
> trace amounts of in your diet, *if it comes from lard*, it
> has no antioxdiant protection, whereas if *it comes from
> good quality nuts*, it does.
Self contradiction; a sure method to upgrade one's
credibility.

Laurie
======

Clearly-articulated enough?? Clearly-articulated enough
the first time it was posted to completely ignore it? But,
let me be even more clear; people who contradict
themselves have NO credibility.

Laurie


If you are having difficulty
> understanding a point I a making, you need to explain
> exactly what the problem is.
>
> Robert: Thank you for reiterating what MattLB and myself
> have been posting here for a few years now (concerning
> oxidized cholesterol). Otherwise, I don't know what you're
> getting at. I'm not going to do the research for you. If I
> happen to come across an abstract that appears to possibly
> satisfy you, I'll post it. Otherwise, go ahead and subject
> your thryoid to all the oxidative stress you wish.

[Robert]

"Laurie" <no@spam.com> wrote in message
news:42471f46$1_2@alt.athenanews.com...
>
> "montygram" <nazztrader@lycos.com> wrote in message news:11-
> 11617178.391124.191490@g14g2000cwa.googlegroups.com...
> > Laurie: exactly what is your claim? I'll take on all
> > comers, but you have to clearly articulate your ideas.
>
> =====
> repeat post:
>
> "montygram" <nazztrader@lycos.com> wrote in message news:11-
> 11513474.354563.257600@z14g2000cwz.googlegroups.com...
> > ..., remember than a linoleic acid molecule is a linoleic
> > acid molecule, regardless of whether it came from an
> > animal or a plant.
> ...
> > So, while linoleic acid is not something you want more
> > than trace
amounts
> > of in your diet, *if it comes from lard*, it has no
> > antioxdiant protection, whereas if *it comes from good
> > quality nuts*, it does.
> Self contradiction; a sure method to upgrade one's
> credibility.
>
> Laurie
> ======

Sounds like a contradiction to me plain and simple. To Monty,
peoples bodies and tissues are exposed to oxidants every
minute of the day and there are anti-oxidant systems that the
body already has. In addition the body produces a vast amount
of oxidants and free radicals generated by it's use of oxygen
so they are localized within each cell in addition to those
oxidants chemicals the cell is bathed in outside the cell.
With a minute damage to the cell by any known mechanism of
injury then the cell collapses because it can not resist that
oxidative stress. To measure oxidative changes in a damaged
cell is a joke.It proves that the cell was damaged and not
that the primary defect was a result of oxidative stress. You
just don't get it.

>
> Clearly-articulated enough?? Clearly-articulated enough
> the first
time
> it was posted to completely ignore it? But, let me be even
> more clear; people who contradict themselves have
NO
> credibility.
>
> Laurie
>
>
>
>
>
>
> If you are having difficulty
> > understanding a point I a making, you need to explain
> > exactly what the problem is.
> >
> > Robert: Thank you for reiterating what MattLB and myself
> > have been posting here for a few years now (concerning
> > oxidized cholesterol). Otherwise, I don't know what you're
> > getting at. I'm not going to do the research for you. If I
> > happen to come across an abstract that appears to possibly
> > satisfy you, I'll post it. Otherwise, go ahead and subject
> > your thryoid to all the oxidative stress you wish.
> >
>

[Mmu]

>> *if it comes from lard*, it has no antioxdiant protection,
>> whereas if *it comes from good quality nuts*, it does.

> Self contradiction; a sure method to upgrade one's
> credibility.

please read up on antioxidants and antioxidant protection,
then post. thanks.

[Mortimer S]

MMu wrote:
> please read up on antioxidants and antioxidant protection,
> then post.

More crossposted horseshit.

[Robert]

"Mortimer Schnerd, RN" <mortschnerd@carolina.rr.com.remove>
wrote in message
news:PXj2e.75825$_i3.4447433@twister.southeast.rr.com...
> MMu wrote:
> > please read up on antioxidants and antioxidant protection,
> > then post.
>
>
>
> More crossposted horseshit.

You just contributed to crossposting. More than once.