Ironjustic
Sat, Mar-19-05, 19:17
J Microbiol. 2005 Feb;43(1):54-61. Related Articles, Links
Growth of Staphylococcus aureus with defective siderophore
production in human peritoneal dialysate solution.
Park RY, Sun HY, Choi MH, Bae YH, Shin SH.
Research Center for Resistant Cells, Chosun University Medical
School, Gwangju 501-759, Republic of Korea.
In this study, we attempted to determine the effects of
iron-availability and the activity of the bacterial
iron-uptake system (IUS) on the growth of Staphylococcus
aureus in human peritoneal dialysate (HPD) solution. A
streptonigrin-resistant S. aureus (SRSA) strain, isolated from
S. aureus ATCC 6538, exhibited defective siderophore
production, thereby resulting in ineffective uptake of iron
from low iron-saturated transferrin. The growth of both
strains was stimulated in HPD solution supplemented with FeCl3
and holotransferrin, but growth was inhibited in HPD solution
which had been supplemented with apotransferrin and dipyridyl.
The SRSA strain grew less robustly than did its parental
strain in both iron-supplemented HPD solution and regular HPD
solution. These results indicate that iron-availability and
siderophore-mediated IUS activity in particular, the ability
to produce siderophores and thus capture iron from low
iron-saturated transferrin play critical roles in the growth
of S. aureus in HPD solution. Our results also indicated that
the possibility of using iron chelators as therapeutic or
preventive agents warrants further evaluation.
PMID: 15765059 [PubMed - in process]
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Who loves ya. Tom
http://herbivore.7h.com
Growth of Staphylococcus aureus with defective siderophore
production in human peritoneal dialysate solution.
Park RY, Sun HY, Choi MH, Bae YH, Shin SH.
Research Center for Resistant Cells, Chosun University Medical
School, Gwangju 501-759, Republic of Korea.
In this study, we attempted to determine the effects of
iron-availability and the activity of the bacterial
iron-uptake system (IUS) on the growth of Staphylococcus
aureus in human peritoneal dialysate (HPD) solution. A
streptonigrin-resistant S. aureus (SRSA) strain, isolated from
S. aureus ATCC 6538, exhibited defective siderophore
production, thereby resulting in ineffective uptake of iron
from low iron-saturated transferrin. The growth of both
strains was stimulated in HPD solution supplemented with FeCl3
and holotransferrin, but growth was inhibited in HPD solution
which had been supplemented with apotransferrin and dipyridyl.
The SRSA strain grew less robustly than did its parental
strain in both iron-supplemented HPD solution and regular HPD
solution. These results indicate that iron-availability and
siderophore-mediated IUS activity in particular, the ability
to produce siderophores and thus capture iron from low
iron-saturated transferrin play critical roles in the growth
of S. aureus in HPD solution. Our results also indicated that
the possibility of using iron chelators as therapeutic or
preventive agents warrants further evaluation.
PMID: 15765059 [PubMed - in process]
--------------------------------------------------------------
-------------------
Who loves ya. Tom
http://herbivore.7h.com