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Sun, Nov-14-04, 18:16
Clin Chim Acta. 2004 Dec;350(1-2):57-63. Related
Articles, Links
Oxidative stress in urogenital tuberculosis patients: a
predisposing factor for renal stone formation-amelioration by
vitamin E supplementation.
Srinivasan S, Pragasam V, Jenita X, Kalaiselvi P, Muthu V,
Varalakshmi P.
Department of Medical Biochemistry, Dr. A.L. Mudaliar Post
Graduate Institute of Basic Medical Sciences, University of
Madras, Taramani, Chennai 600 113, India.
BACKGROUND: Previous studies have shown that urogenital
tuberculosis (GuTb) patients treated or untreated with regular
anti-Tb regimen excrete comparatively high levels of urinary
stone forming constituents than normal subjects. Enhanced
oxidative stress is also considered as a prime factor that
accelerates urolithiasis. The present study was aimed to
determine antioxidant status and lipid peroxidation of these
individuals in order to assess their risk for kidney stone
formation. METHODS: GuTb patients and age-matched normal
subjects were divided into four groups: I: normal subjects
(n=60), II: GuTb patients a day before treatment (n=72), III:
GuTb patients after treatment with isoniazid (300 mg),
rifampicin (450 mg) and pyrazinamide (1.5 g) per day for 60
days (n=42), and IV: GuTb patients supplemented with vitamin E
(200 mg/day) along with regular chemotherapy for 60 days
(n=30). Blood was collected and tested for various markers of
oxidative stress. RESULTS: Increased levels of lipid
peroxidation, protein carbonyls (PCO), advanced oxidative
protein products (AOPP) and reduced antioxidant defenses by
impairment in enzyme activities like superoxide dismutase,
catalase, glutathione peroxidase, reduced glutathione and
decreased plasma concentrations of non enzymatic antioxidants
like vitamins C and E were observed in the treated and
untreated GuTb patients. CONCLUSIONS: These biochemical
disparities may lead to membrane disintegrity, which is
favorable for retention of mirolithis. Advocation of vitamin E
enhanced the antioxidant status of the plasma, thereby
preventing membrane injury, consequently reducing the risk of
stone formation in urogenital tuberculosis patients, who were
treated with their routine anti-tuberculosis drug regimen.
PMID: 15530460 [PubMed - in process]
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Articles, Links
Oxidative stress in urogenital tuberculosis patients: a
predisposing factor for renal stone formation-amelioration by
vitamin E supplementation.
Srinivasan S, Pragasam V, Jenita X, Kalaiselvi P, Muthu V,
Varalakshmi P.
Department of Medical Biochemistry, Dr. A.L. Mudaliar Post
Graduate Institute of Basic Medical Sciences, University of
Madras, Taramani, Chennai 600 113, India.
BACKGROUND: Previous studies have shown that urogenital
tuberculosis (GuTb) patients treated or untreated with regular
anti-Tb regimen excrete comparatively high levels of urinary
stone forming constituents than normal subjects. Enhanced
oxidative stress is also considered as a prime factor that
accelerates urolithiasis. The present study was aimed to
determine antioxidant status and lipid peroxidation of these
individuals in order to assess their risk for kidney stone
formation. METHODS: GuTb patients and age-matched normal
subjects were divided into four groups: I: normal subjects
(n=60), II: GuTb patients a day before treatment (n=72), III:
GuTb patients after treatment with isoniazid (300 mg),
rifampicin (450 mg) and pyrazinamide (1.5 g) per day for 60
days (n=42), and IV: GuTb patients supplemented with vitamin E
(200 mg/day) along with regular chemotherapy for 60 days
(n=30). Blood was collected and tested for various markers of
oxidative stress. RESULTS: Increased levels of lipid
peroxidation, protein carbonyls (PCO), advanced oxidative
protein products (AOPP) and reduced antioxidant defenses by
impairment in enzyme activities like superoxide dismutase,
catalase, glutathione peroxidase, reduced glutathione and
decreased plasma concentrations of non enzymatic antioxidants
like vitamins C and E were observed in the treated and
untreated GuTb patients. CONCLUSIONS: These biochemical
disparities may lead to membrane disintegrity, which is
favorable for retention of mirolithis. Advocation of vitamin E
enhanced the antioxidant status of the plasma, thereby
preventing membrane injury, consequently reducing the risk of
stone formation in urogenital tuberculosis patients, who were
treated with their routine anti-tuberculosis drug regimen.
PMID: 15530460 [PubMed - in process]
--------------------------------------------------------------
-------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking