Doe
Mon, Aug-16-04, 19:18
Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
Related Articles, Links
Antioxidant enzyme and malondialdehyde values in social phobia
before and after citalopram treatment.
Atmaca M, Tezcan E, Kuloglu M, Ustundag B, Tunckol H.
Firat (Euphrates) Universitesi, Firat Tip Merkezi Psikiyatri
Anabilim Dali, 23119, Elazig, Turkey, matmaca_p@yahoo.com
A growing body of evidence indicates that oxidative stress is
involved in the etiopathogenesis of some psychiatric
disorders. In our previous study, we have found that social
phobia (SP) seems to be associated with elevated antioxidant
enzymes and malondialdehyde (MDA) levels, a lipid peroxidation
product. In the present investigation, we sought to determine
whether the increased radical burden observed in patients with
SP would be attenuated with alleviation of symptoms.
Thirty-nine patients diagnosed with generalized SP and 39
healthy controls participated in this study. The measurements
of MDA, superoxide dismutase (SOD), glutathione peroxidase
(GSH-Px) and catalase (CAT) were performed before and after a
period of 8 weeks of citalopram treatment. In this period, the
patients received citalopram but controls did not. The initial
dose of citalopram was 20mg, with 20 mg increments occurring
every 2 weeks, to a maximum dose of 60mg, with the mean daily
dose of 38.9 +/- 13.3 mg/day. All patients were evaluated by
using Liebowitz Social Anxiety Scale (LSAS). The mean MDA,
SOD, GSH-Px and CAT levels of the patient group at baseline
were significantly higher than those of controls. Antioxidant
enzymes and MDA levels decreas significantly through
citalopram treatment. Significant and positive correlation was
observed between decrease in the total LSAS scores, and SOD or
CAT levels. In conclusion, our results suggest that, in
patients with SP, subchronic treatment with citalopram may
decrease antioxidant enzymes and MDA values and that they are
state markers of SP because they return to normal values with
treatment.
PMID: 15309392 [PubMed - in process]
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http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
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Related Articles, Links
Antioxidant enzyme and malondialdehyde values in social phobia
before and after citalopram treatment.
Atmaca M, Tezcan E, Kuloglu M, Ustundag B, Tunckol H.
Firat (Euphrates) Universitesi, Firat Tip Merkezi Psikiyatri
Anabilim Dali, 23119, Elazig, Turkey, matmaca_p@yahoo.com
A growing body of evidence indicates that oxidative stress is
involved in the etiopathogenesis of some psychiatric
disorders. In our previous study, we have found that social
phobia (SP) seems to be associated with elevated antioxidant
enzymes and malondialdehyde (MDA) levels, a lipid peroxidation
product. In the present investigation, we sought to determine
whether the increased radical burden observed in patients with
SP would be attenuated with alleviation of symptoms.
Thirty-nine patients diagnosed with generalized SP and 39
healthy controls participated in this study. The measurements
of MDA, superoxide dismutase (SOD), glutathione peroxidase
(GSH-Px) and catalase (CAT) were performed before and after a
period of 8 weeks of citalopram treatment. In this period, the
patients received citalopram but controls did not. The initial
dose of citalopram was 20mg, with 20 mg increments occurring
every 2 weeks, to a maximum dose of 60mg, with the mean daily
dose of 38.9 +/- 13.3 mg/day. All patients were evaluated by
using Liebowitz Social Anxiety Scale (LSAS). The mean MDA,
SOD, GSH-Px and CAT levels of the patient group at baseline
were significantly higher than those of controls. Antioxidant
enzymes and MDA levels decreas significantly through
citalopram treatment. Significant and positive correlation was
observed between decrease in the total LSAS scores, and SOD or
CAT levels. In conclusion, our results suggest that, in
patients with SP, subchronic treatment with citalopram may
decrease antioxidant enzymes and MDA values and that they are
state markers of SP because they return to normal values with
treatment.
PMID: 15309392 [PubMed - in process]
--------------------------------------------------------------
-------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking