Flavanol-rich cocoa drink / oxidative stress

[Doe]

Free Radic Biol Med. 2004 Aug 1;37(3):411-21. Related
Articles, Links

Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane
concentrations in humans.

Wiswedel I, Hirsch D, Kropf S, Gruening M, Pfister E, Schewe
T, Sies H.

Institut fur Klinische Chemie und Pathobiochemie,
Otto-von-Guericke-Universitat Magdeburg, Germany.

Flavan-3-ols are potent antioxidants in vitro, but convincing
evidence for antioxidant action in vivo is lacking. We
examined whether an oxidative stress-mediated increase in
plasma F(2)-isoprostanes is counteracted by a flavanol-rich
cocoa beverage. Twenty volunteers were examined in a
comparative randomized double-blind crossover design with
respect to ingestion of high-flavanol cocoa drink (HFCD; 187
mg flavan-3-ols/100 ml) vs. low-flavanol cocoa drink (LFCD; 14
mg/100 ml). With 10 individuals, the treatment was combined
with strenuous physical exercise. Total (esterified plus
nonesterified) F(2)-isoprostanes were analyzed by GC/MS. LFCD
caused a slight increase in the mean (+/- SEM) plasma
concentrations of F(2)-isoprostanes 2 and 4 h after intake
(2.16 +/- 0.19 nM at 4 h vs. 1.76 +/- 0.11 nM at 0 h, n = 10),
which may be attributable to postprandial oxidative stress.
This increase did not occur with HFCD (1.57 +/- 0.06 nM at 4 h
vs. 1.65 +/- 0.10 nM at 0 h, n =
10). The difference in F(2)-isoprostanes 2 and 4 h after
intake of HFCD vs. LFCD became statistically significant
when the intake was combined with physical exercise (P <
0.01, ANOVA). We conclude that dietary flavanols, using
cocoa drink as example, can lower the plasma level of
F(2)-isoprostanes, indicators of in vivo lipid
peroxidation.

PMID: 15223075 [PubMed - in process]

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[markd]

I read this too, intresting, the last of a recent string of
such research related to cocoa. The only question about cocoa
is it's high glycation end products, ages, which are produced
in the preperation of cocoa. These tend to work against it's
antiox benefits. Also one has to be aware that not all cocoa
is equal in it's antiox content, some preperation methods from
the bean state remove/destroy most of it.

>Free Radic Biol Med. 2004 Aug 1;37(3):411-21. Related
>Articles, Links
>
>
>Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane
>concentrations in humans.
>
>Wiswedel I, Hirsch D, Kropf S, Gruening M, Pfister E, Schewe
>T, Sies H.
>
>Institut fur Klinische Chemie und Pathobiochemie,
>Otto-von-Guericke-Universitat Magdeburg, Germany.
>
>Flavan-3-ols are potent antioxidants in vitro, but convincing
>evidence for antioxidant action in vivo is lacking. We
>examined whether an oxidative stress-mediated increase in
>plasma F(2)-isoprostanes is counteracted by a flavanol-rich
>cocoa beverage. Twenty volunteers were examined in a
>comparative randomized double-blind crossover design with
>respect to ingestion of high-flavanol cocoa drink (HFCD; 187
>mg flavan-3-ols/100 ml) vs. low-flavanol cocoa drink (LFCD;
>14 mg/100 ml). With 10 individuals, the treatment was
>combined with strenuous physical exercise. Total (esterified
>plus nonesterified) F(2)-isoprostanes were analyzed by GC/MS.
>LFCD caused a slight increase in the mean (+/- SEM) plasma
>concentrations of F(2)-isoprostanes 2 and 4 h after intake
>(2.16 +/- 0.19 nM at 4 h vs. 1.76 +/- 0.11 nM at 0 h, n =
>10), which may be attributable to postprandial oxidative
>stress. This increase did not occur with HFCD (1.57 +/- 0.06
>nM at 4 h vs. 1.65 +/- 0.10 nM at 0 h, n =
>10). The difference in F(2)-isoprostanes 2 and 4 h after
> intake of HFCD vs. LFCD became statistically significant
> when the intake was combined with physical exercise (P <
> 0.01, ANOVA). We conclude that dietary flavanols, using
> cocoa drink as example, can lower the plasma level of
> F(2)-isoprostanes, indicators of in vivo lipid
> peroxidation.
>
>PMID: 15223075 [PubMed - in process]
>
>Who loves ya. Tom Jesus Was A Vegetarian!
>http://jesuswasavegetarian.7h.com Man Is A Herbivore!
>http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
>PEOPLE WALKING
>http://pages.ivillage.com/ironjustice/deadpeoplewalking