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Mult Scler. 2004 Jun;10(3):266-71. Related Articles, Links
Association of apolipoprotein E and myeloperoxidase genotypes
to clinical course of familial and sporadic multiple
sclerosis.
Zakrzewska-Pniewska B, Styczynska M, Podlecka A, Samocka R,
Peplonska B, Barcikowska M, Kwiecinski H.
Department of Neurology, The Medical University of Warsaw,
02-097 Warsaw, Banacha 1A, Str., Poland. beza@amwaw.edu.pl
The importance of apolipoprotein E (ApoE) and myeloperoxidase
(MPO) genotypes in the clinical characteristics of multiple
sclerosis (MS) has been recently emphasized. In a large group
of Polish patients we have tested the hypothesis that
polymorphism in ApoE and MPO genes may influence the course
of the disease. Genotypes were determined in 117 MS patients
(74 females and 43 males; 99 sporadic and 18 familial cases)
with mean EDSS of 3.6, mean age of 44. 1 years, mean duration
of the disease 12.8 years and mean onset of MS at 31.2 years,
and in 100 healthy controls. The relationship between ApoE
and MPO genes' polymorphism and the MS activity as well as
the defect of remyelination (diffuse demyelination) and brain
atrophy on MRI were analysed. The ApoE epsilon4 allele was
not related to the disease course or the ApoE epsilon2 to the
intensity of demyelination on MRI. The genotype MPO G/G was
found in all familial MS and in 57% (56/99) of sporadic
cases. This genotype was also related to more pronounced
brain atrophy on MRI. The MPO G/G subpopulation was
characterized by a significantly higher proportion of
patients with secondary progressive MS (P < 0.05) and by a
higher value of EDSS. According to our results the MPO G
allele is frequently found (in 96% of cases) among Polish
patients with MS. More severe nervous tissue damage in the
MPO G/G form can be explained by the mechanism of accelerated
oxidative stress. It seems that MPO
G/G genotype may be one of the genetic factors influencing the
progression rate of disability in MS patients.
PMID: 15222689 [PubMed - in process]
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Association of apolipoprotein E and myeloperoxidase genotypes
to clinical course of familial and sporadic multiple
sclerosis.
Zakrzewska-Pniewska B, Styczynska M, Podlecka A, Samocka R,
Peplonska B, Barcikowska M, Kwiecinski H.
Department of Neurology, The Medical University of Warsaw,
02-097 Warsaw, Banacha 1A, Str., Poland. beza@amwaw.edu.pl
The importance of apolipoprotein E (ApoE) and myeloperoxidase
(MPO) genotypes in the clinical characteristics of multiple
sclerosis (MS) has been recently emphasized. In a large group
of Polish patients we have tested the hypothesis that
polymorphism in ApoE and MPO genes may influence the course
of the disease. Genotypes were determined in 117 MS patients
(74 females and 43 males; 99 sporadic and 18 familial cases)
with mean EDSS of 3.6, mean age of 44. 1 years, mean duration
of the disease 12.8 years and mean onset of MS at 31.2 years,
and in 100 healthy controls. The relationship between ApoE
and MPO genes' polymorphism and the MS activity as well as
the defect of remyelination (diffuse demyelination) and brain
atrophy on MRI were analysed. The ApoE epsilon4 allele was
not related to the disease course or the ApoE epsilon2 to the
intensity of demyelination on MRI. The genotype MPO G/G was
found in all familial MS and in 57% (56/99) of sporadic
cases. This genotype was also related to more pronounced
brain atrophy on MRI. The MPO G/G subpopulation was
characterized by a significantly higher proportion of
patients with secondary progressive MS (P < 0.05) and by a
higher value of EDSS. According to our results the MPO G
allele is frequently found (in 96% of cases) among Polish
patients with MS. More severe nervous tissue damage in the
MPO G/G form can be explained by the mechanism of accelerated
oxidative stress. It seems that MPO
G/G genotype may be one of the genetic factors influencing the
progression rate of disability in MS patients.
PMID: 15222689 [PubMed - in process]
--------------------------------------------------------------
-------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking