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Thromb Res. 2004;113(6):345-51. Related Articles, Links
Vitamin E improves fibrinolytic activity in patients with
coronary spastic angina.
Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T,
Hokamaki J, Yoshimura M, Nakamura H, Yodoi J, Ogawa H.
Department of Cardiovascular Medicine, Graduate School of
Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto
860-8556, Japan.
Introduction: The fibrinolytic system has a major role as a
defense mechanism against thrombus formation. Net fibrinolytic
activity in plasma reflects the balance between tissue-type
plasminogen activator and plasminogen activator inhibitor
(PAI). PAI is the main factor determining overall fibrinolytic
activity. Materials and methods: We examined the effects of
oral administration of vitamin E, an antioxidant, on
fibrinolytic activity and oxidative stress in patients with
coronary spastic angina. Forty patients with coronary spastic
angina were randomly assigned into two treatment groups,
either vitamin E group (alpha-tocopherol acetate, 400 mg/day)
or placebo group by means of computerized system. PAI activity
and thioredoxin, a marker of oxidative stress, levels were
measured before and at the end of 1 month treatment. Results:
Before treatment, the levels of PAI activity and thioredoxin
were increased in patients with coronary spastic angina as
compared with control subjects (n=17) (PAI activity levels:
13.6+/-1.4 vs. 7.6+/-2.2 IU/ml, p<0.05, thioredoxin levels:
22.8+/-1.7 vs. 16.0+/-1.4 ng/ml, p<0.05). In patients with
coronary spastic angina, administration of vitamin E decreased
both PAI activity and thioredoxin levels (PAI activity levels:
14.7+/-1.7 to 7.5+/-1.6
IU/ml, p<0.01, thioredoxin levels: 23.3+/-2.4 to 15.1+/-2.5
ng/ml, p<0.01), whereas placebo had no effect on these
variables. Conclusions: Oral administration of vitamin E
improved fibrinolytic activity and the improvement was
associated with a decrease in oxidative stress.
Administration of vitamin E is possible to be an effective
adjunct therapy of coronary spasm in the absence of
coronary atherosclerosis.
PMID: 15226088 [PubMed - in process]
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http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
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Vitamin E improves fibrinolytic activity in patients with
coronary spastic angina.
Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T,
Hokamaki J, Yoshimura M, Nakamura H, Yodoi J, Ogawa H.
Department of Cardiovascular Medicine, Graduate School of
Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto
860-8556, Japan.
Introduction: The fibrinolytic system has a major role as a
defense mechanism against thrombus formation. Net fibrinolytic
activity in plasma reflects the balance between tissue-type
plasminogen activator and plasminogen activator inhibitor
(PAI). PAI is the main factor determining overall fibrinolytic
activity. Materials and methods: We examined the effects of
oral administration of vitamin E, an antioxidant, on
fibrinolytic activity and oxidative stress in patients with
coronary spastic angina. Forty patients with coronary spastic
angina were randomly assigned into two treatment groups,
either vitamin E group (alpha-tocopherol acetate, 400 mg/day)
or placebo group by means of computerized system. PAI activity
and thioredoxin, a marker of oxidative stress, levels were
measured before and at the end of 1 month treatment. Results:
Before treatment, the levels of PAI activity and thioredoxin
were increased in patients with coronary spastic angina as
compared with control subjects (n=17) (PAI activity levels:
13.6+/-1.4 vs. 7.6+/-2.2 IU/ml, p<0.05, thioredoxin levels:
22.8+/-1.7 vs. 16.0+/-1.4 ng/ml, p<0.05). In patients with
coronary spastic angina, administration of vitamin E decreased
both PAI activity and thioredoxin levels (PAI activity levels:
14.7+/-1.7 to 7.5+/-1.6
IU/ml, p<0.01, thioredoxin levels: 23.3+/-2.4 to 15.1+/-2.5
ng/ml, p<0.01), whereas placebo had no effect on these
variables. Conclusions: Oral administration of vitamin E
improved fibrinolytic activity and the improvement was
associated with a decrease in oxidative stress.
Administration of vitamin E is possible to be an effective
adjunct therapy of coronary spasm in the absence of
coronary atherosclerosis.
PMID: 15226088 [PubMed - in process]
--------------------------------------------------------------
-------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking