increased oral iron intake / stroke damage

[Doe]

It seems diet high in iron may contribute to the EXTENT of
damage in stroke .. 50% more chance of EXTREME .. damage ..

<<snip>> These results suggest that the iron overload that
increases both superoxide and nitric oxide production leads to
peroxynitrite formation, thus enhancing brain damage. <<snip>>

J Physiol Biochem. 2003 Dec;59(4):249-54. Related
Articles, Links

Does nitric oxide contribute to iron-dependent brain injury
after experimental cerebral ischaemia?

Gamez A, Carbonell T, Rama R.

Departamento de Fisiologia, Division III, Universidad de
Barcelona, Spain.

Experimental and clinical data suggest that iron has a key
role in cerebral ischaemia. We measure infarct volume and
analyse the nitric oxide responses to brain injury in rat
stroke model after increased oral iron intake. Permanent
middle cerebral artery occlusion (MCAO) was performed in a
group of 20 male Wistar rats, 10 of which were fed with a
control diet and 10 of which were fed with iron-enriched diet
containing 2.5% carbonyl iron for 9 weeks. L-arginine and
nitric oxide metabolites were determined in blood samples
before and at 2, 6, 8 and 48 h after MCAO. Infarct volume,
thiobarbituric acid reaction substances (TBARS) and tissue
iron were measured at 48 h. Infarct volume was 66% greater in
the iron-fed rats than in the control group. Iron-fed animals
showed significantly higher levels of TBARS. Liver iron stores
(3500 +/- 199 vs 352 +/- 28 microg Fe/g, p<0.0001) but not
brain iron stores (131 +/- 11 vs 139 +/- 8 microg Fe/g,
p=0.617), were significantly higher in the iron-fed group.
L-arginine levels were slightly lower in iron-fed rats and
decreased significantly in both groups at 6 and 8 hours after
MCAO. The levels of the stable end products of NOS (NOx =
nitrite + nitrate) were significantly higher in iron-fed rats
before MCAO (16.2 +/- 2.2 vs. 9.6 +/- 0.8 micromol x L(-1),
p<0.05), with a further increase during the six first hours
after MCAO in both groups. These results suggest that the iron
overload that increases both superoxide and nitric oxide
production leads to peroxynitrite formation, thus enhancing
brain damage.

PMID: 15164943 [PubMed - in process]

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[markd]

It seems abnormal iron stores may so contribute, in normal
levels it would then not be a question. Iron was elevated by
abnormal feeding of abnormal levels of iron. Strokes happen in
the brain, thus:

"but not brain iron stores"

sSo the brain damage made by the researchers was not made
worse by iron in the brain but by ox radical activity
elsewhere,ie. the liver. Iron does not cause strokes and in
normal levels, the vast majority of the population, unlike
these induced overload levels, it probably will not cause
further damage.

>It seems diet high in iron may contribute to the EXTENT of
>damage in stroke .. 50% more chance of EXTREME .. damage ..
>
><<snip>> These results suggest that the iron overload that
>increases both superoxide and nitric oxide production
>leads to peroxynitrite formation, thus enhancing brain
>damage. <<snip>>
>
> J Physiol Biochem. 2003 Dec;59(4):249-54. Related
> Articles, Links
>
>
>Does nitric oxide contribute to iron-dependent brain injury
>after experimental cerebral ischaemia?
>
>Gamez A, Carbonell T, Rama R.
>
>Departamento de Fisiologia, Division III, Universidad de
>Barcelona, Spain.
>
>Experimental and clinical data suggest that iron has a key
>role in cerebral ischaemia. We measure infarct volume and
>analyse the nitric oxide responses to brain injury in rat
>stroke model after increased oral iron intake. Permanent
>middle cerebral artery occlusion (MCAO) was performed in a
>group of 20 male Wistar rats, 10 of which were fed with a
>control diet and 10 of which were fed with iron-enriched diet
>containing 2.5% carbonyl iron for 9 weeks. L-arginine and
>nitric oxide metabolites were determined in blood samples
>before and at 2, 6, 8 and 48 h after MCAO. Infarct volume,
>thiobarbituric acid reaction substances (TBARS) and tissue
>iron were measured at 48 h. Infarct volume was 66% greater in
>the iron-fed rats than in the control group. Iron-fed animals
>showed significantly higher levels of TBARS. Liver iron
>stores (3500 +/- 199 vs 352 +/- 28 microg Fe/g, p<0.0001) but
>not brain iron stores (131 +/- 11 vs 139 +/- 8 microg Fe/g,
>p=0.617), were significantly higher in the iron-fed group.
>L-arginine levels were slightly lower in iron-fed rats and
>decreased significantly in both groups at 6 and 8 hours after
>MCAO. The levels of the stable end products of NOS (NOx =
>nitrite + nitrate) were significantly higher in iron-fed rats
>before MCAO (16.2 +/- 2.2 vs. 9.6 +/- 0.8 micromol x L(-1),
>p<0.05), with a further increase during the six first hours
>after MCAO in both groups. These results suggest that the
>iron overload that increases both superoxide and nitric oxide
>production leads to peroxynitrite formation, thus enhancing
>brain damage.
>
>PMID: 15164943 [PubMed - in process]
>
>-------------------------------------------------------------
>--------------
>------
>
>
>Who loves ya. Tom Jesus Was A Vegetarian!
>http://jesuswasavegetarian.7h.com Man Is A Herbivore!
>http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
>PEOPLE WALKING
>http://pages.ivillage.com/ironjustice/deadpeoplewalking